Front cover image for Cancer drug resistance : overviews and methods

Cancer drug resistance : overviews and methods

eBook, English, ©2016
Humana Press : Springer, New York, ©2016
Laboratory Manual
1 online resource (xiii, 314 pages) : illustrations (some color)
9781493933471, 9781493933457, 1493933477, 1493933450
941809597
Cancer Drug Resistance: A Brief Overview from a Genetic Viewpoint.- Classical and Targeted Anti-Cancer Drugs: An Appraisal of Mechanisms of Multidrug Resistance.- In Vitro Methods for Studying the Mechanisms of Resistance to DNA Damaging Therapeutic Drugs.- In Vitro Approaches to Study Regulation of Hepatic Cytochrome P450 (CYP) 3A Expression by Paclitaxel and Rifampicin.- Uptake and Permeability Studies to Delineate the Role of Efflux Transporters.- Dynamics of Expression of Drug Transporters: Methods for Appraisal.- Fluorimetric Methods for Analysis of Permeability, Drug Transport Kinetics, and Inhibition of the ABCB1 Membrane Transporter.- Resistance to Targeted Therapies in Breast Cancer.- MicroRNAs and Cancer Drug Resistance.- The Role of MicroRNAs in Resistance to Current Pancreatic Cancer Treatment: Translational Studies and Basic Protocols for Extraction and PCR Analysis.- Methods for Studying MicroRNAs Expression and Their Targets in Formalin-Fixed, Paraffin-Embedded (FFPE) Breast Cancer Tissues.- The Regulatory Role of Long Non-Coding RNAs in Cancer Drug Resistance.- Cancer Exosomes as Mediators of Drug Resistance.- Isolation and Characterization of Cancer Stem Cells from Primary Head and Neck Squamous Cell Carcinoma Tumors.- Clinical and Molecular Methods in Drug Development: Neoadjuvant Systemic Therapy in Breast Cancer as a Model.- Proteomics in the Assessment of the Therapeutic Response of Anti-Neoplastic Drugs: Strategies and Practical Applications.- Managing Drug Resistance in Cancer: Role of Cancer Informatics.