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Try Keasby & Mattison's Bromo-caffeine for headaches.

FROM DR. H. R. HOPSON, MEMPHIS, TENN.-This is to certify that I have made use of Colden's Liquid Beef Tonic in several cases of consumption and general debility, and have found it to act admirably in such cases as a nutritive food and tonic.

Use Willis H. Davis' Improved Clinical Thermometor. Write to him (Keokuk, Iowa) for revised catalogue of surgical instruments.

Prescribe McArthur's Syrup of the Hypophosphites. It is a thoroughly good article.

We have used Mellier's Peptonic Elixir and know it to be an excellent preparation.

Every one praises the Kidder batteries. They are very reliable for clinical use.

Chas. Lentz & Sons, 18 N. 11th Street, Philadelphia, handle none but the best of surgical instruments.

Put in an apparatus of the American Oxygen Association, 119 E. 28th Street, New York, in your office, and be the only one in your town this winter who can use oxygen in the treatment of respiratory affections.

We can testify to the merits of Hepatic Extract Write to the Hunt-Kiddie Co., 91 and 93 Wall Street, New York, for a sample.

Have you not yet found a mineral water to exactly suit you? Write to Thomas F. Goode, Buffalo Lithia Spring, Va., for pamphelet.

W. F. Ware, 70 N. 3d Street, Philadelphia, manufactures a line of goods that you frequently need.

We have personally inspected the batteries made by the Partz Electric Battery Co., 636 Arch Street, Philadelphia, and find them to be excellent.

Every lady patient must have her own syringe. Those who try the Lady's Syringe never need any other. Write to the Goodyear Rubber Co., 57 Maiden Lane, New York.

Peroxide of hydrogen is now a practical reality, and can be used as other therapeutical agents are used. See ad. of Ch. Marchand.

See the matchless apparatus for inhalation by Charles Beseler, 218 Centre Street, New York.

Write to the Rudisch Company, 317 Greenwich Street, New York. for information concerning their SarcoPeptones.

By ordering your supporters, elastic stockings, etc., of A. H. Garson, 1304 Master Street, Philadelphia, you avoid the extra profits of the middle man, and get firstclass goods at manufacturers' prices.

Try Planten's capsules.

WHAT COCAINE TO USE.-There are many brands of Cocaine in the market and many physicians have found to their annoyance that some are inert and some very irritating when applied to a sensitive membrane.

It may therefore be of service to physicians to learn the experience of Dr. Dudley S. Reynolds, editor of (Continued over next leaf.)

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Beside the above, Antifebrin continues to enjoy the decided preference of the Medical Profession OVER ALL OTHER ANTIPYRETICS; being, f. i., of Four Times the Strength of Antipyrine,-according to the Clinical Report of Drs. A. Cahn and P. Hepp of Prof. Kussmaul's Clinique at the University of Strassburg.

Abstracts of numerous Medical Reports on the above-mentioned qualities of ANTIFEBRIN Will be mailed on application Manufacturing [73 WILLIAM ST., Chemist,

to the Sole Licensee

for the U.S.:

E. MERCK,

{78

New York.

Platt's Chlorides,

A LIQUID DISINFECTANT.

ODORLESS, COLORLESS, POWERFUL, ECONOMICAL.

ENDORSED BY OVER 16,000 PHYSICIANS.

INVALUABLE IN THE SICK ROOM.

A NECESSITY IN THE HOUSEHOLD.

Sold by Druggists in quart bottles only. Price 50c.

To any physician who may still be unacquainted with it, a sample will be sent free of expense, if this journal is mentioned, by addressing

HENRY B. PLATT, 36 Platt St., New York.

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PHYS

HYSICIANS who prepare or keep their own medicines in stock, or who have their preparations ready-made at the drug store, will please take notice, that Peptic Ferments in liquid form gradually loose their digestive property and become totally inert. They should therefore never be carried in stock, but be prepared only when prescribed. Owing to this fact, we manufacture no liquid preparations of Pepsin.

Our Pepsin in its scaly (so called crystal form,) or in powdered state preserves its digestive strength for years. This Pepsin has won for itself a reputation all over the world phenominal in pharmaceutical literature. When prescribed in powder form Pulvis Aromaticus furnishes the best vehicle or adjuvant. Always underline the name CARL L. JENSEN'S when prescribing our Pepsin.

CARL L. JENSEN CO.,

100 Maiden Lane, New York.

Progress, who in the July, 1888, number expresses himself in this wise:

"The medical profession has about settled its estimate of the therapeutical value of muriate of cocaine; but it is, unhappily, no easy matter to decide upon the most uniformly reliable source of supply. The editor of Progress had about concluded Merck's was the only reliable product, when recently he was induced to make trial of that produced by Parke, Davis & Co. A fresh sample of ten grains was dissolved in five drachms of distilled water, to which was added one drop of liquid carbolic acid. One drop of this instilled into the eye of a man from whose cornea a foreign body was to be removed, produced complete anesthesia in three minutes, so that incision of the inflamed cornea, and turning out of the piece of offending metal was not felt by the patient. Twenty other similar experiments yielded similar results."

Special $5.00 Combinations

for November.

During the months of December and January, specially, our business is very heavy. In order to get a part of this same business in November, and to that extent relieve the rush, we will make the following $5.00 Combinations, good only during the present month (November). No variation can be made to suit special cases. For example, if you already have one of the articles named in a special combination that you want to accept, the price of this article cannot be de

A

ducted from the $5. You could in that case arrange with some other physician to take the extra article.

FOR $5.00 DURING NOVEMBER, 1888.

Manual of Treatment. Medical World Visiting List. Ledger of Monthly Balances.

For $5.00 during November, 1888.
Medical World Visiting List.
Ledger of Monthly Balances.
Official Formula of American Hospitals.
The MEDICAL WORLD for 1888.
Three MEDICAL WORLD Binders.
Chart, Urine in Disease, and Chart of Skin Diseases.

FOR $5.00 DURING NOVEMBER, 1888.

Manual of Treatment.

Official Formulæ of American Hospitals. The MEDICAL WORLD for 1889. (New Subscribers may have the December, 1888 issue free.)

FOR $5.00 DURING NOVEMBER, 1888.

Manual of Treatment.

The MEDICAL WORLD for 1889.
One MEDICAL WORLD Binder.
Chart, Urine in Disease.
Chart of skin Diseases.

RE you tired of carrying a bulky, heavy visiting list in your pocket constantly?

RE you tired transferring your original entries into secondary books?

RE you tired of running the risk of losing what you have earned by keeping your accounts in signs?

The Medical World Visiting List

relieves you from all this. It consists of an elegant leather case and twelve removable sections, (one for each month of the year). The case has a pocket for prescription blanks, an erasible tablet for pencil memoranda, and a place for fastening the visiting list section. Each section has 46 pages ruled for monthly accounts, each date being printed, and space for name and address of patient, services for each separate day of the month and amount charged for each day, monthly total, credits and balance. Any section can be used for any month, or part of any month.

When a section is full it can be removed and a new one inserted; thus the list is never large nor heavy, yet it, capacity is unlimited, as it can constantly be renewed.

Sufficient space is given to write each entry in words, thus avoiding the use of signs, which are not recognized by courts of law. To be legal, an account must be originally entered in words.

The monthly arrangement of accounts is a great convenience.

This list, together with its companion, "Ledger of Monthly Balances," (price 50 cents), makes a complete set o account books for a physician, and they are the most convenient ever produced.

PRICE OF LIST, (Case and Twelve Removable Sections),

LEDGER OF MONTHLY BALANCES,

$1.50

.50

THE MEDICAL WORLD.

The knowledge that a man can use is the only real knowledge; the only knowledge that has life and growth in it and converts itself into practical power. The rest hangs like dust about the brain, or dries like raindrops of the stones.-FROUDE.

The Medical World.

Sa

ubscription to any part of the United States and Canada, ONE DOLLAR per year. To England and the British Colonies FIVE SHILLINGS per year. Postage free. These rates must be paid invariably in advance.

Notice is given on the wrapper when your subscription expires. You are invited to renew promptly, when this notice is given. This is necessary if you wish to continue to receive THE WORLD, as it is sent only as long as paid for.

We cannot always supply back numbers. Should a number fail to reach a subscriber, we will supply another, if notifled before the end of the month.

Pay no money to agents for this journal unless publisher's receipt is given.

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issue.

1530 Chestnut Street,

PHILADELPHIA, PA.

DECEMBER, 1888.

No. 12.

Thousands of subscriptions expire with this As you know, THE MEDICAL WORLD is modest, and will not continue its visits to you unless invited. It does not belong to that numerous class of journals that a physician has to "die to get rid of."

If you consider a subscription to THE MEDICAL WORLD a good investment, you will, of course, renew. If any do not think so, we do not wish them to renew; for we want to give full value for value received. This is our plain, straightforward business position.

There is no time like the present; therefore the best time to attend to this is now, before you put this down. Then it will be done, and you will continue to receive your WORLD regularly. Please use order blank on page xxxv, and order what other articles mentioned there that you may wish. Particularly do not forget the Binder, for it will be of great use if you value THE WORLD. Some physicians use it for other journals also.

You will see by the announcement in this issue that a very elaborate index to our 1888 volume is being prepared by Dr. House, of Detour, Mich. As it is impossible to have it ready for this issue (notice that we never allow our index to encroach on the regular amount of reading matter), we will send it out with the January issue. Fortunately this year we are able to furnish the full 1888 volume to those who have not been subscribers, or any missing numbers to subscribers, at the regular price, $1 for the volume, or 10 cents per single copy.

Our journal has been compared to a vast medical society, uniting the most distant points of our country, with frequent voices from other countries, and that our plan makes possible a monthly meeting of this vast society. We often think of our subscribers as a large medical family, each anxious to help and to receive help, and with a brotherly feeling pervading all:

We cannot close this familiar talk with you without thanking the many who have sent us encouraging words, together with the subscripby correspondence inducing their distant meditions of their neighbor physicians, some even

cal friends to subscribe, or subscribing for them. We wish for you continued prosperity, and trust that our pleasant relations may continue.

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Report Remedies Tried and Found Useless. Medicine is necessarily a progressive science, and there is certainly room yet for advancement. Many remedies for the treatment of disease have been proposed, mainly on theoretical grounds, which do not fulfill the hopes entertained for them. But, in the meantime, the original recommendation of them, based upon such reasoning or upon insufficient tests, has gone abroad, and each practitioner is obliged to ascertain their worthlessness for himself, to the danger of his patients and the detriment of his practice.

It is important to know what is not worthy

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Physiological Meditation.

A person, to become skilled in certain manual and artistic work, as instrumental music, needlework, engraving, drawing, and many others, must undergo long training and practice. Query: Is this simply a process of educating the individual cells of which his tissues are composed to obey the commands of the will?

The old cells decay and are removed by the proper channels, and their place supplied by new ones. After the artist, musician or mechanic has left off practice for some time, he finds himself "out of practice." Query: Is the subsequent necessary practice required to educate the new cells before entire proficiency is again attained?

Shall we liken it unto an army, in which the places of those who fall in battle are filled by raw recruits; thus necessitating a careful drilling of the entire body, that the new soldiers may learn the service?

But the artist, as well as the army, recovers in a short time the former degree of skill. Perhaps that is because the new members are carried along, so to speak, by the already acquired experience of the older ones, having simply to

follow and imitate them.

Cellular physiology is the basis of cellular pathology. It would be interesting if we could trace this out to a discovery of the source of talent, and finally of genius.

Cineraria Maritima.

Our investigations have not led us to any re liable corroboration of the favorable report of this remedy for cataract, as casually mentioned in August WORLD. We fear it will have to be numbered among the long list of medical ignes fatui. Should we be able to reach anything more reliable on the subject, our readers will at once have the benefit of it.

Gonorrhea.

Many are troubled with the difficulty with which this disease is combated. If it only be considered as an inflammation of a mucous membrane with a specific or microbic cause, the appropriate treatment becomes simple enough. We will first consider treatment by injections. Sulphate of thallin, four grains to the ounce of distilled water, is said to cut short the disease with a few applications.

We have found excellent results from one grain each of cocaine, morphine, atropine, chloral hydrate, sulphate of zinc and sulphocarbolate of zinc to the ounce of distilled or rose water. After the acute stage has subsided, withdraw the cocaine first, then the atropine, chloral and the zinc salts as long as there is any and then the morphine, continuing with the irritability of the urethra.

The king of injections for lingering sub-acute gonorrhea or gleet is the following:

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The constitutional conditions to be considered are plethora and debility. Plethora increases the intensity of the inflammatory stage and protracts its duration. The only remedy necessary is saline laxatives during the stage indicated. Debility prolongs the sub-acute stage and favors chronicity. Tincture of the chloride of iron (always given some time before meals) is the most appropriate remedy for the condition, beginning with the beginning of the subacute stage.

As internal treatment the sulphide of calcium should be given from the start, and during the entire period of suppuration, one-tenth grain ten times daily. If debility exists, one grain of locto phosphate of lime should be taken with each dose.

The following is an excellent combination, to be taken from the very first:

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