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ness and heat in the mouth; thirst; towards evening the pains disappeared.

26th.-90 drops at 9 o'clock in the morning; at the expiration of a quarter-of-an-hour, an oppressive pain and burning between the cardiac region and navel, as well as in the sternum; pain in the nape of the neck and back of the head; tearing pain in the forehead over the left eye, in the eye, and eyelid, extending towards the upper part of the nose; drawing pains between the shoulder-blades, extending to the loins; shortness of breathing, and oppression as if the breast were tied together, and the breath could not force a way out; shivering, and a feeling of coldness over the whole body till midday; towards evening a pressing pain in the forehead and back of the head; alterations of heat and cold with a thirst for Breihan (a kind of light effervescing beer made without hops); burning urine, with frequent urging to pass it; palpitations of the heart; she is unable to go to sleep at once, on account of drawing sensation in the loins,

and headache.

27th.-She awoke shortly after 4 o'clock with achings in her loins, and headache; arms as if paralysed, a thrilling in them; shortness of breath, short cough, anxiety, nausea; pricking and ringing in the left ear; in something less than an hour she fell asleep again till past 6 o'clock. After getting up, weakness in her limbs; great weariness; depressed spirits; pains in the knees and drawing pains in the calves; in the evening, anxiety; acute pain in the head, over the right ear; face hot; throat, tongue, and lips dry; dreamt much in the night, but has no recollection of the subjects of her dreams.

28th.-Awoke after 4 o'clock with anxiety; stitch in the left side; oppression of the chest; cannot draw a long breath on account of the stitch; oppressive headache in the forehead and occiput; face hot; gentle perspiration; no thirst; she soon fell asleep again till past 6 o'clock; after rising, headache, anxiety; a paralysed feeling in her arms and legs.

6. EXPERIMENT ON L., A DOCTOR'S ASSISTANT.

L., 45 years old, sanguine temperament, pale countenance, light hair. Suffers occasionally at changes of weather from debility; eats sparingly, drinks no fermented liquors; bowels regular; perfectly well at the time of experiment; colds are attended with catarrh.

Nov. 14th.-90 drops at 9 o'clock in the morning; after a quarter of an hour, dizziness, a feeling of heat running over the whole body, pain in the nape of the neck. At the end of an hour pains in the temples particularly, much dragging pain, so that my whole head is affected; nausea, as if I would vomit, but relieved by eructations; uneasiness in the chest; the dizziness again becomes stronger; much anxiety; oppression of the stomach; much eructation; after which a rigor makes its appearance. At 10.30, a hollow rumbling in the abdomen; gripings towards the rectum; my mouth is quite dry, so that my tongue almost cleaves to my palate. renewed pains in front of my stomach; renewed feeling of heat over the whole body; pains in front of neck which extend towards the temples; from 11 till 1 o'clock, shudders through the loins; renewed drawing in the temples; renewed nausea, which is again relieved by repeated eructations; lassitude and paralysed feeling of the limbs; renewed nausea, eructations, shiverings in the loins, and much heat in the head; twitchings in the legs and loins; pains in the temples; much anxiety and oppression of the chest; pain in the stomach, and nausea, which is again relieved by numerous eructations. At 7 o'clock in the evening, gripings of the bowels, so severe that my whole body seemed drawn together; urgent desire to stool; three watery motions in quick succession, after which the griping abated in about half an hour; the whole evening a great discharge of wind.

7.-EXPERIMENT ON PASTOR G.

Pastor G. of this place, 52 years old, of sanguineo

phlegmatic temperament; suffered in his youth from ischias nervosa for which he was treated with mercury in many forms. From the effects of this medicine he lost his hair from the forehead and crown of the head, and never recovered it. Subsequently he suffered from bloody piles; is sensible of changes of the weather, and suffers, on taking cold, from cough and slight rheumatic pains. Appetite and digestion good. At the time free from all complaints.

On the 6th January, at 9 a.m., took 20 drops of Mother tincture. Soon after, strong discharges of wind, both upwards and downwards; urging sensations in the rectum; uncomfortable feeling in the bowels, as when one has had an evacuation after taking a purgative; metallic acetose taste on the tongue; unpleasant smell in the nose like that of black soft soap; eructations till bed time.

7th, 9 a.m.-Took 30 drops. Immediately afterwards strong discharges of wind upwards and downwards; secretion of thin mucus in the throat; increased appetite; motion of the bowels delayed and confined. In the afternoon oppression and coldness in the abdomen, which was not removed by a warm blanket; coldness over the whole body, especially close under the umbilical region; drawing pain in the right side, from above downwards.

8th, 8 a.m.-Took 40 drops. Eructations and discharges of wind; greater appetite; increased secretion of mucus from the throat. Natural motion of the bowels, but a feeling accompanied the operation as if the anus were constricted, and only permitted the fæces to pass with difficulty; later, another stool, soft and lighter coloured; taste of a fine acid on the tongue. Towards evening a drawing and pressure between the shoulders, especially in the right scapula, and towards the right side; a feeling as if the larynx were swollen, especially on the right side.

9th, 8 a.m.-Took 50 drops. Increased expectoration of mucus, and now and then a running at the nose; eructations; much mucus in the mouth; in the afternoon drawing between the shoulders; stronger stream of urine; in the afternoon and evening shuddering thrill from the nape of the

neck to the loins downwards; unusual feeling of chill in the bowels after drinking some water; cramps in the right calf; no motion of the bowels throughout the day.

10th. No dose taken for fear of constipation. Evacuation of the bowels; signs of blood on wiping the anus; appetite was not so good in the morning as on the day before.

11th, about 9 a.m.-Took 10 drops. Immediately eructations; increased expectoration of mucus; fluent coryza; feeling of chill in the body on drinking water, not usually the case; great discharge of wind; watery eyes; affection of the head; motion of the bowels lighter coloured than usual; cold shudders between the shoulders; uncomfortable feeling throughout the body; vertigo; an evacuation of a light colour and pappy consistency, followed by improvement in the state of things.

12th, 9 a.m.-Took 5 drops. Repetition of yesterday's symptoms, but less severe, at mid-day 5 drops more; great feeling of discomfort in the body with pains, relieved by a glass of wine; confusion of the head again supervened; pressure on the eyelids; cold feet; distension and uneasiness of the body, notwithstanding frequent eructations; lassitude, without the ability to sleep; later, hot, burning feet; next morning a scanty stool with itching of anus.

13th. Took no dose. Stool lighter coloured than usual. 14th, 1 p.m.-Took 2 drops. Immediately after, eructations of wind; pains in the nape of the neck; expectoration of mucus; pressure in the fore and back parts of the head; horripilation in the back; stiffness of the neck on the left side; pain in the right shoulder, in the muscles of the right side of the neck, and in the region of the right clavicle; fluent coryza; coldness of body; shivering; the next morning a soft, light yellow stool.

8. EXPERIMENT ON PASTOR H.

Pastor H-, in D-, 52 years old, choleric, sallow, pale complexion, black hair; inclined to rheum and catarrh of the

stomach on catching cold; well developed muscular system; good appetite; regular alvine discharges; liver freckles on the skin.

November 25th, 10 a.m.,-Took 90 drops. In ten minutes the head was stupefied; dull; oppression in the nape of the neck; secretion of thin mucus from the throat and nose; water in the mouth; oppression in the stomach, relieved by eructations. A feeling of heat throughout the whole body, especially in the face and hands. Towards evening, dull pain in the head, with shivering; a roughness in the throat, with water in the mouth; stitches in the region of the stomach; drawings in the loins.

26th.-Vertigo; roughness in the throat and watery discharges from the nose; increased appetite in the morning and mid-day (which continued for several weeks); several thin liquid stools daily (for eight days); small vesicles on the lips and alæ nasi (subsequently forming scabs); dull oppression in the ears; itching of the anus (continuing for some days, occasionally felt before); pressure on the bladder, and frequent discharges of urine; frequent erections, even in the day; good spirits; more inclination to speak much in company.

The following day all these symptoms gradually became weaker, and the appetite stronger. Irritability of the bladder, and greater cheerfulness continued for three weeks after taking the dose.

9.-EXPERIMENT ON MISS AUGUSTA H.

Miss Augusta H—, of D—, 50 years old; sanguine temperament, light hair; suffered two years previously from scarlatina, and this year from measles; bowels regular; pale complexion; weak muscles; inclined to thinness; perspires easily; skin moist every morning on awaking; great liability to take cold, on such occasions catarrh and cough; appetite good.

November 25th, 8 a.m.-Took 90 drops of the Mother tincture. After a few minutes it was evident by the excitement of manner, that a condition resembling intoxication had set in. She felt her head giddy and confused; pressure

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