resist the force of all, except the ultimate action of the last, and there may be constitutional contoxic. ditions when all prove

The following is a list of remedies with the symptomatology of some of their untoward ef

fects:

ACETATE OF LEAD. Loss of appetite, constipa-
tion, paralysis and colicky attacks.*
ACIDS. Disturbance of digestion, toothache, and
occasionally there is salivation.

ACID ARSENIC. Irritation of the stomach, der-
matitis, stomatitis, headache, dry cough,
salivation, etc.

ACID, BORACIC. Nausea, vomiting, fullness of
the stomach.a
ACID, CARBOLIC. Headache, dizziness, weak-

ness of the legs, the appearance of rings be-
fore the eyes, a sensation as of crawling in-
sects and profuse sweating,b nephritis, at-
tacks of fainting in women,d hiccup, nausea,
chills, and anasarca with diminution or sup-
pression of urine.e

ACID, PICNIC. Occasionally causes an icteric

discoloration of the skin and conjunctiva.f ACID, SALICYLIC. Buzzing in the ears, difficulty

of hearing and profuse perspiration, y weakness in the legs, mental depression with severe headache, gastric disturbance, eruption of the skin, and collapse. The sugar reaction is given by urine of patient taking salicylic acid.

ACID, TANNIC. Pain in the stomach and abdomen, violent emesis and constipation. ALOES. Large doses may act as an abortifacient

congestion of the descending colon and rectum, dilatation of the hemorrhoidal veins.k ALUM. Gastric disturbance, and may induce cough.m Yellow vision, impairment AMYL, NITRITE. of the acuteness of vision, vertigo and stupor followed by headache, mental aberration, delirium, collapse with paresis, or serious vertigo and embarrassment of respiration./

ANTIFEBRIN and ANTIPYRIN.

Exanthems, col

Binswagner.

d Prætorius.

gStricker.

jGoltdammer. Dr. L. Lewin. Sander.

pVeyrieres.
rUrbantschitsch.
t Kobner.

Richardson.
Stille.

¿Neuman. eEdwards.

Muller.

kFollopius.
m Beginund.
oSchroeter.
qBourneville.
sGuerard.
ul. Munk.

Lucke. ƒSeitz. ¡Heinlein.

Simpson. ySydney Ringer.

tions.

Eczema

CAMPHOR. May give rise to headache, dizziness, slight mental confusion, flushing of the face, with dryness of the mouth and thirst. m In large doses there occur vomiting, strangury, heat, clammy perspiration, increased frequency of pulse, and delirium.c CANNABUS INDICA. A blunting sense of touch, with a sensation in the lower extremities as as if asleep, vertigo, visual delusions, pue slight delirium,n a high state of hilarity, hallucination and illusions.h CANTHARIDES.

Nausea, vomiting, diarrhoea, painful chordee, increased desire to urinate, the urine occasionally containing blood, albumen or morphological constituents.c An erysipelatous dermatatis. CASHEW NUT. Nausea, vomiting, diarrhoea, and CELENDINE. headache, sometimes causing a papular or vesicular eruption of the skin.a

CHINOLINE.

ach.

Pain and irritability in the stom

CHLORAL. A sense of fear, dyspnoea, and even asphyxia,b irregular action of the heart,e bronchitis,d conjunctivitis with congestion of the head,e swelling of the epiglottis, and false vocal cords, ficterus,g erythema,e and urticariæ.h

CHLORATE OF POTASSIUM.

Should be entirely

rejected in the treatment of children.i Irratibility of the stomach, choking sensation, epistaxis, pain in the region of the kidneys, hæmaturia, albuminuria, and delirium.i

CHLORIDE OF AMMONIUM. Nausea, vomiting, a diarrhoea and colic. The continued use of the drug in moderate doses usually gives rise to constipation, which is due to an atonic condition of the intestines.a CHLORIDE OF BARIUM. Nausea, vomiting, loss of appetite, colicky pains, oppression in the epigastrum and diarrhoea. Catarrhal irritation of the conjunctiva, of the nasal and respiratory mucous surface-may induce salivation, a foulodor of the breath, and loosening of the teeth.k

CHLORIDE OF GOLD. Gives rise to a feeling of

heat, and burning in the skin, gastric disturbance, colic and diarrhoea./ CHLORIDE OF POTASSIUM. Mental confusion, drowsiness, torpidity, pain in the limbs, diminished power of motion, difficulty of speech, loss of appetite.m

CHLOROFORM. Persistent vomiting, pallor of the face, labored and stertorous respiration, extreme dydriasis, spasmodic muscular movement, muscular rigidity, and a small, scarcely perceptible pulse.

CHRYSAROBINE. Locally, may cause diffuse redness and swelling, vesicles and pustules, and even painful furuncles.

pe

COD LIVER OIL. Nausea, vomiting, diarrhoea.a After large doses, the skin gives off the culiar odor of the volatile fatty acids of the oil. It may also produce an eruption of a vesicular nature."

COLCHICUM. Burning in the throat and stom

ach, ptyalism, distressing nausea, and serious diarrhoea with tenesmus, and later, chills with sleeplessness.d COLOMBO ROOT. Nausea, vomiting, gastric pain, loss of consciousness.e COPAIBA. Roscola, f eczema. CREOSOTE. Dryness of the mouth, a burning sensation of the stomach, a white coating of the tongue, and increased frequency of the pulse. There may be vomiting and strangury attended with persistent headache.h CROTON OIL. In addition to its drastic purgative action, an irritative burning taste in the mouth, dryness, and burning in the throat, eructations, nausea, and colicky pains. DUBOISIA. Its principal effect is to cause dilata

tion of the pupils. The untoward effects are dryness of the throat and disturbance of the sight, thirst increased, frequency of the pulse, redness of the skin, and occasionally collapse, dryness of the skin, vertigo, restlessness and delirium, follicular conjunctivitis. ¿

ERGOT. Sickening taste, irritation of the throat,

increased secretion of saliva, nausea, burning in the stomach, abdominal pains, eructations, vomiting and diarrhoea, headache, dizziness, dilatation of the pupils, debility, uncertainty of gait, and irregularity of the

HYOSCYAMUS May cause erythema b or pustular eruptions, e dilatation of the pupils, dizziness, weakness and collapse, swelling of the parotids, salivation, and catarrh of the nasal mucous membrane. The prolonged employment of the drug may cause a sickly aspect, and, frequently, the occurrence of boils.e

IODIDE OF POTASSIUM. Pain in the stomach, f catarrhal effects on the mucous membranes, loss of the sense of smell, oedema of the eyelids, a sensation of a foreign substance in the eye,d profuse lachrymation, and a burning sensation of the nose and throat,g diplopia and weakness of vision, and the following form of eruptions: Erythematous urticaria, like nodulo-pustular eczema i and petechia.j

IODOFORM. Somnolence, gait difficult and uncertain, headache, vertigo, double vision, incoherence of speech, a feeling of anxiety and twitching of the muscles of the face and trunk, dizziness,k mental confusion, paralysis of the sphincters, and finally, death may suddenly occur. I

IPECAC. May give rise to gastric and intestinal catarrh, with its natural consequences anorexia, and diarrhoea, frequently tinged with blood. The latter occurs most frequently when vomiting is not excited.d JABORANDI. Among the untowards is nausea and vomiting that is extremely distressing and exhausting to the patient, irritation of the mucous membrane of the palate, throat, etc., burning pain in the urethra and in the lumbar region, with a disire to urinate, defective sight, salivation, cedema of the lungs has followed the subcutaneous exhibition of pilocarpin, o vomiting is usually followed by collapse.p

JALAP. Large and frequent repeated doses may give rise to catarrhal inflammation of the gastro-intestinal mucous membrane. MEZEREON. As a vesicant it may be followed by headache, dryness of the throat, an irritative cough, fever, unconsciousness, convulsions, and finally death.a

MORPHIA. A feeling of anxiety, nausea and vomiting, an intensely bitter or sour taste, b

TAR. Nausea, headache, dizziness, vomiting or diarrhoea with abdominal pain. TARTAR EMETIC. Vomiting, delirium, spasm and collapse,h causes gastric disturbances, excessive vomiting, and an antimonial eruption. i THYMOL. A burning sensation in the mouth and gastric region, a perspiration, buzzing in the ears, and partial deafness. VALERIAN. May cause a scraping sensation in the throat, eructation, nausea, a feeling of constriction of the throat, borborygmi, diarrhoea, colicky pains, and anorexia,a and even hallucinations of sight.c VERATRIUM. Even small normal doses usually excite dryness of the mouth, burning in the throat, difficult deglutition, nausea, choking and vomiting, and occasionally also salivation, colicky pains, and diarrhoea, in which the discharges may be tinged with blood. In many persons there occur vertigo and dimness of vision, and also a trembling and uncertainty of motion. In others, completely developed collapse may ensue.a may likewise cause a pustular eruption on the face.d

It

Pathological Synchronous Action.

Under the reaction of a powerful pathological synchronous action caused by a medicine, a dis ease may be at times subdued as if by magic; but it might be well to estimate at what cost of the vital forces such a cure is effected. This is forcibly demonstrated in the treatment of gout and rheumatism with colchicum. It may give prompt relief, but it may prove ruinous to the general health of the patient afterwards. The potential effects of tartar emetic in an infantile inflammation of the respiratory organs may give relief to the immediate disease, but too often the remedy tends to a disease in its place that can not be subdued for months afterwards, if at all. Almost any heroic treatment with remedies of great force, may thus at times be productive of both good and evil results. Such a treatment can only be recommended in the strong and vigorous with a sanguine temperament, and in these exceptions even, should only be employed to overcome a very violent pathological action. Thus it may be necessary to treat the intense attacks of fever caused by miasmatic influences with arsenic. As small doses would have little effect, it is necessary to prescribe almost toxic doses producing the state of collapse and inducing accidents more or less approaching the choleriform symptoms.a

Remedies of this class often render relief by the laws of revulsion, as traumatic coma may often be removed by the introduction of a few drops of croton oil into the rectum. Counterirritants likewise come under this action, but from the fact that they are usually remedies of

external use, they are less liable to leave bad effects.

But there may be a pathological synchronous action of spontaneous development, and not brought about by medicines. Nature usually occupies itself with but one disease, but at times it may institute another of a more serious nature, usually in some distant part of the body. Thus a connection may exist between a chronic disease of the kidneys and cardiac hypertrophybetween gout, and some other diseases, and diabetes and lithiasis may be caused by a disease of the liver, and end with diabetes. The liver under a functional inactivity, not dehydrating the sugar of the portal vein into glycogen is the antecedent of diabetes of the kidneys. Gout often carries with it a hypertrophy of the heart.

Morbid Complications of Diseases that Should not Always be Interfered With.

There may be a disease, or a predisposition to a disease, that is kept at bay by some minor existing disease. Thus a cutaneous eruption may save a child from eclampsia-hemorrhoids may stay the development of phthisis-ulcers of the legs may prevent apoplexy and even insanity, etc. There are at times, morbid complications in gout, which it is highly dangerous to interfere with; as, to check a stifled cough with anodynes may endanger the life of the patient, and to stop a diarrhoea before the kidneys are once more in action, is equally as dangerous.

We cannot be too careful in the resort to opium, in cases of kidney troubles. It is apt to end in the establishment of uræmia. In uremic diarrhoea with suppression of urine (more or less complete), opium must on no account be used.

However, there may be complications that may run such a course as to make it imperative to give them medical attention. But where they are cured by treatment, the patient should be kept under some medical substitution for the malady removed, for a long period, either through a special treatment of the existing disease, or be kept under prophylactics for the predisposition to disease. In many instances the best prophylactic is some pleasant form of an alterative aperient, judiciously administered, like the cascara cordial. The question is one of importance in a surgical point of view.

Isomerics.

Isomeric bodies are not only constituted out of the same element, but in the same proportion, and yet they are endowed with the most varied properties. For example, here are starch, gum and dextrine, which have in common the formula of C 12 H 10 O 10; they are all isomerics, but very different substances. Terebene is isomeric with turpentine. The isomeric substances obtained from quinquina, are quinine-which is of great power-and quinidine and quinicine,

bDr. G. P. Hachenberg, Cincinnati Medical News, 1880, p. 586.