Response Variability to Psychotropic DrugsW. Janke |
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Page 231
... Placebo Lofepramine 1 2 3 4 5 6 7 day Fig . 2. Mean depression scores of the adjective check list " day mood " for the seven days with placebo resp . lofepramine medication ; * signifcant drug - placebo difference at p2.05 . Figure 2 ...
... Placebo Lofepramine 1 2 3 4 5 6 7 day Fig . 2. Mean depression scores of the adjective check list " day mood " for the seven days with placebo resp . lofepramine medication ; * signifcant drug - placebo difference at p2.05 . Figure 2 ...
Page 253
... placebo ) as forming a dichotomized variable in a composite sample which com- prises both placebo - treated and iproniazid - treated patients . Biserial correlation coefficients may be computed between the dichotomous treatment - no ...
... placebo ) as forming a dichotomized variable in a composite sample which com- prises both placebo - treated and iproniazid - treated patients . Biserial correlation coefficients may be computed between the dichotomous treatment - no ...
Page 255
... Placebo and ECT Groups ( n = 97 ) Depression Phobia Paranoia ( state ) Suicidal ( state ) Displacing ( trait ) -.22 Self - critical ( trait ) * ECT or Placebo -.29 .23 Anxiety -.31 -.37 * Biserial correlations ; a negative correlation ...
... Placebo and ECT Groups ( n = 97 ) Depression Phobia Paranoia ( state ) Suicidal ( state ) Displacing ( trait ) -.22 Self - critical ( trait ) * ECT or Placebo -.29 .23 Anxiety -.31 -.37 * Biserial correlations ; a negative correlation ...
Contents
Drug Response Variability Overview of Contributing Factors | 31 |
Somatic factors as predictors of psychotropic drug response | 67 |
Genetic and early environmental factors in response variability | 97 |
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activity administration adrenergic drugs alcohol amitriptyline analysis antidepressant anxiety arousal behavioral biochemical blood levels changes chlordiazepoxide chlorpromazine Claridge Clin clinical concentration correlation Debus depressant drugs depressed patients diazepam DiMascio dose drug effects drug metabolism drug postulate drug response variability drug tolerance emotional responses environmental and situational enzyme evidence experiment experimental extraverts females genetic factors H. J. Eysenck hexobarbitone imipramine increase individual differences influence interaction introverts investigated iproniazid Janke kinetic Lienert lofepramine male measures ment meprobamate neurotic neuroticism nicotine nortriptyline orciprenaline performance personality traits pharmacokinetic Pharmacol pharmacological physiological placebo plasma levels prediction predictors pretreatment Psychiatry psychoactive drugs Psychol psychological psychopharmacology psychotropic drugs questionnaire reactions relationship reported response variability sample sedation threshold significant situational conditions smoking behaviour somatic specific stimulant studies subjects scoring symptoms Table theory therapeutic tion tranquilizers treatment variability to psychotropic variance Wesnes Wittenborn