Methods in Renal Toxicology
The only up-to-date compilation of renal methods available, this book is the definitive resource for any renal researcher eager to stay ahead. Methods in Renal Toxicology presents a vast array of methods for the study of renal cellular and tubular structure, function, and biochemistry under physiological, toxicological, and pathological conditions. It provides detailed descriptions in easy-to-understand language of methods designed to enhance your research efforts.
Methods in Renal Toxicology puts you on the cutting edge with valuable chapters detailing molecular methods and transgene and gene targeting - the most recent approaches to the study of renal toxicology. Overall, the book's topics range from non-invasive assessments of renal function in the whole animal and clinical settings to cellular and molecular approaches. Specifically, the book delves into measurements of clearance and urinary markers, histopathology, and methods to assess renal carcinogenesis, mutagenesis, oxidative stress, mitochondria injury, cellular repair, and drug metabolism and transport. A variety of in vitro methods are also described, including the isolated perfused kidney, micropuncture, microperfusion, microdissection, renal slices, isolated perfused tubules, suspensions of tubules and isolated cells, and primary cell cultures and cell lines.
Methods in Renal Toxicology is a must-have resource for all renal investigators. Nowhere else can you find concise descriptions of traditional and up-to-the-minute renal toxicology methods in such a practical, well-written single-volume guide.
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Clearance Methods in Renal Toxicology
Histopathologic Methods in Renal Toxicology
The Isolated Perfused Kidney
Micropuncture and Microperfusion Techniques
Microdissection and Microanalysis of Specific Nephron Segments from Mammalian Kidney
Preparation and Use of PrecisionCut Renal Cortical Slices in Renal Toxicology
In Vitro Perfusion of Isolated Nephron Segments A Method for Renal Toxicology
Immortalized Cell Lines of Renal Cells
Methods in Renal Carcinogenesis and Mutagenesis
Measurement of Reactive Oxygen Species Oxidative Damage and Antioxidant Systems in the Kidney
Mechanisms of Repair After Renal Injury
Mitochondrial Toxicity in Renal Injury
Biotransformation and Membrane Transport in Nephrotoxicity
Methods to Evaluate Renal Cytochrome P450 as a Bioactivation System for Nephrotoxicants
Molecular Methods in Renal Toxicology
Suspensions of Rabbit Renal Proximal Tubules
Characterization and Use of Rabbit Renal Proximal Tubular Cells in Primary Culture for Toxicology Research
Use of Freshly Isolated and Primary Cultures of Proximal Tubular and Distal Tubular Cells from Rat Kidney
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acid activity antisense assay bathing solution Biochem Biol buffer cannula catalase cell lines cellular centrifugation chemicals clearance collagenase collecting ducts collection pipette concentration cortex creatinine cytochrome detection determined digitonin diluted distal DT cells effects enzyme epithelial cells ethanol expression filtration fluid fraction function gene glomerular glomeruli glutathione GSSG incubation induced inhibition injury intracellular inulin isolated perfused rat kidney Kidney Int marker measured medium membrane metabolism method microdissection microperfusion micropuncture microscope microsomes mitochondrial mouse mRNA nephron nephron segments nephrotoxicity Northern blot oxide oxygen perfused perfused rat kidney Pharmacol phosphate Physiol pipette plasma preparation primary cultures probe procedure protein proximal tubular cells proximal tubule rabbit renal radiolabeled Reagents renal cells renal cortex renal cortical renal proximal tubule RPTs samples slices sodium specific studies substrate suspensions technique toxicity Toxicol Toxicology transfection transgenic transgenic mice transport tube tubular segment tumors urine vitro vivo volume xenobiotic