Lymphatic Transport of DrugsLymphatic Transport of Drugs provides a thorough review of the determinants that affect the uptake and delivery of drugs and xenobiotics to the lymphatics. Factors affecting the transport and delivery of lipophilic drugs through the lymph after oral administration, lymphatic transport of polar drugs and macromolecules after gastrointestinal dosing, transport of drugs into the lymph after parenteral administration, and particulate drug delivery systems are among the topics examined in this volume. Lymphatic Transport of Drugs is primarily intended for pharmaceutical scientists who are attempting to alter the delivery of current therapeutic agents through formulation of prodrugs, as well as for researchers designing new drugs for lymph delivery. |
Contents
TABLE OF CONTENTS | 8 |
Lymph Flow 14 445 | 14 |
Anatomy and Physiology of the Lymphatics 1 | 19 |
Role of Lymphatics in Exchange in Normal Tissue | 20 |
Effect of Administration Route on Lymphatic Delivery | 29 |
Chapter 2 | 37 |
Chapter 3 | 63 |
Chapter 4 | 113 |
Lipophilic Prodrugs and the Promotion of Intestinal Lymphatic Drug | 175 |
Chapter 6 | 211 |
Chapter 7 | 233 |
Chapter 8 | 255 |
Particulates and Lymphatic Drug Delivery | 279 |
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Common terms and phrases
a-tocopherol absorbed Acta bile acids bile salts bioavailability Biochim Biol Biophys blood capillaries cannula cells Chem cholesterol chylomicrons clearance Clin compounds concentration conjugate cyclosporin dextran drug delivery effect emulsion enhanced enterocyte enzymes esters fatty acids Figure fluid fluorescent formulation fraction gastrointestinal glyceride Hashida hydrolysis increased infusion injection interstitial intestinal absorption intestinal lymphatic transport L-Dopa lipase lipid lipid digestion products Lipid Res lipid vehicles lipophilic lipophilic drugs liposomes liver LK-A lumen lymph flow lymph nodes lymphatic absorption lymphatic capillaries lymphatic delivery lymphatic drug transport lymphatic system macromolecules mesenteric lymph metabolism metastasis micellar micelles microscopy mitomycin mixed micelles MMCD molecular weight molecules monoglyceride Muranishi oral administration pancreatic particles pathway permeability Pharm Pharmaceut phospholipids Physiol plasma portal blood prodrug protein retinol role Sezaki small intestine soluble studies synthesis systemic circulation testosterone thoracic duct tissue tocopherol transport of lipophilic triglyceride uptake vitamin VLDL