Reactive Oxygen Species in Chemistry, Biology, and Medicine

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A. Quintanilha
Springer Science & Business Media, Jun 29, 2013 - Science - 232 pages
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A NATO Advanced Study Institute on "Oxygen Radicals in Biological Systems: Recent Progress and New Methods of Study" was held in Braga, Portugal between Sep tember 1 and September 14, 1985, in order to consider the basic chemistry and biochem istry of activated oxygen (both radical and non-radical species) and their effect in biolog ical systems. This book summarizes the main lectures given at this meeting. While there is no attempt to cover all the major topics in the expanding subject of oxidative mechanisms in biology, an effort has been made to provide overviews on some key aspects of this field. The authors have attempted to convey a clear picture of both what is known and what remains unclear in their respective subjects. Not only are some of the techniques used for detecting activated oxygen species described, but also their strengths and limi tations. The chemistry of many of these species is discussed and the biological and/or pathological implications are carefully reviewed. The medical and therapeutic aspects of some of the well established pathways of damage and protection are analyzed. It is our hope that the material included in this book might be useful for both researchers and teachers at the graduate level. The success of this meeting was to a large extent due to the tireless committment of Professor Alberto Amaral and Dr. Concei~a:o Rangel; without their outstanding efforts in dealing with all the aspects of the organization, this summer school would not have been possible.
 

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Contents

Free Radical Mechanisms of Tissue Injury and Mechanisms of Protection
1
Glutathione Peroxidase Selenium and Vitamin E in Defense Against Reactive
15
Formation and Properties of Oxygen Radicals
37
The Autooxidation of Polyunsaturated Lipids
55
Organic Peroxy Free Radicals and the Role of Superoxide Dismutase
81
Determination of Dissolved Oxygen in Photosynthetic Systems and Protective
97
Biological Chemiluminescence
117
The SuperoxideGenerating NADPH Oxidase of White Blood Cells
143
Role of Reactive Oxygen Species and Lipid Peroxidation in ChemicallyInduced
157
Oxidative Effects of Physical Exercise
187
Oxidative and Peroxidative Damage and its Role in the Aging Process
211
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