stances. The alcohol and ether solutions are said to burn with a strongly sooting flame. Cannabindon is represented by the formula C,H12O. In doses of from 3 to 1 grains (0.02 to 0.08 gramme) this drug causes a state of exciting intoxication instead of sleep.

Dermol, analogous to dermatol—said to be a chrysophanate of bismuth (Bi(C15H,O5)1⁄2Bi2O3), a yellow amorphous powder, soluble in nitric and sulphuric acids with the production, respectively, of a saffron-yellow and a violet-red solution-and chroatol, resulting from the action of iodine upon turpentine, are two new dermic agents that have found favor in cutaneous therapeutics. The clinical data, however, are so far insufficient.

Diabetin (lævulose) has been used in diabetic cases with good results. The dose of this remedy is put down as 15% ounces (50 grammes) a day.

Lactophenin, a derivative of phenacetin, is described as a white insipid powder, soluble in 330 parts of water. This new medicament is reported to have analgesic, hypnotic, and antipyretic properties. It has been employed as a substitute for antipyrin. As an antipyretic lactophenin appears to have rendered good service in the treatment of typhoid fever, producing also, in this disease, a quieting influence on the delirium. The dose of lactophenin is given as from 10 to 15 grains (0.60 to I gramme) three times a day.

Naphthol-camphor has been tried with apparently excellent results in the treatment of tubercular adenitis. In cases of this disease subcutaneous injections of the drug are recommended. (See Naphthol, p. 138.)

Nuclein is a phosphorated proteid extracted from the spleen and other organs. It occurs in the form of a light-yellow-colored powder, soluble in alkaline solu

tions, but insoluble in alcohol or in water. In doses of from 30 to 45 grains (2 to 3 grammes), properly diluted, nuclein is said to enhance phagocytosis by increasing the number of white corpuscles. This remedy has been employed hypodermatically, with apparent success, in the treatment of pleurisy and pneumonia.

Orchidin, a substance obtained from testicular fluid, is claimed to act therapeutically like spermine, but appears to be an unstable preparation. Reliable clinical data are still wanting.

Rubidium iodide has lately been proposed as a succedaneum for the potassium salt. The iodide of rubidium occurs in odorless white crystals having a taste resembling that of potassium iodide, and is more soluble than the latter remedy. Rubidium iodide can be given internally, in milk, in tablespoonful doses of a 1: 40 aqueous solution. As a local application in eye affections it can be employed from solutions of the strength of I: 20, and in diseases of the skin, in the form of ointment with vaseline, also of the strength of : 20.

Tannigen, or acetyltannin, is a compound of acetyl and tannin. This new remedy appears in the form of a yellowish-gray powder, odorless and tasteless, slightly hygroscopic, and melting at 374° F. (190° C.). It is freely soluble in cold alcohol and in dilute solutions of borate, carbonate, and phosphate of sodium. Tannigen has been employed with good results in the treatment of chronic diarrhoeas, especially those occurring in phthisical individuals. This remedy is administered internally in doses of from 3 to 71⁄2 grains (0.20 to 0.50 gramme), and even as high as 60 grains (4 grammes) a day. Locally applied in a 3 per cent. solution in 5 per cent. of sodium-phosphate solution, tannigen has rendered good service in the treatment of chronic pharyngitis.

Tussol is the common name applied to the amygdalate of antipyrin, which is soluble in water. This remedy is highly recommended in the treatment of whooping-cough of children. Tussol is best given in aqueous solutions with raspberry syrup, in doses of from 3/4 of a grain to 6 grains (0.05 to 0.40 gramme), according to the age of the patient. The daily amount for a child one year old is put down as from 3/4 of a grain to 11⁄2 grains (0.05 to 0.10 gramme).

INDEX OF DISEASES.