is said to be of value in the treatment of epilepsy, and is employed in place of the potassium salt.

Administration. This remedy is best given in emulsion or capsules, in doses of 6 to 12 drops or minims (0.18) to 0.74 gramme) three times a day; for a child ten years of age, 10 drops (0.60 gramme) twice a day, increasing cautiously. This remedy may be given hypodermatically.

EUCALYPTEOL.

This new body has been obtained from the oil of eucalyptus by means of hydrochloric acid. It is chemically the hydrochlorate of eucalyptene.

Physical Properties.—Eucalypteol is a white, micaceous, scaly substance having an aromatic camphor-like odor and a peculiar feeble but persistent taste. Its melting-point is at 122° F. (50° C.).

Solubility.—Eucalyptene hydrochlorate is soluble in alcohol, chloroform, ether, fatty and volatile oils, and petroleum; it is scarcely soluble in water.

Physiological Action.-Eucalypteol is said to be nonpoisonous and to be borne well by the stomach. It is largely eliminated by the bronchial and salivary secretions, the urine, and the intestinal secretions, in all of which its presence is shown by a peculiar faint but appreciable aroma.

Therapeutic Applications.-This new drug has given. excellent results in acute and chronic bronchitis, as well as in other diseases of the lungs. As a gastro-intestinal disinfectant it has rendered great service in typhoid fever, diarrhoea, green stools, and in other similar disorders.

Administration.—Eucalypteol is best administered in capsules or in wafers. For adults the daily dose, in divided quantities and best given between meals, may be set down as 221⁄2 grains (1.5 grammes). To children the remedy is best administered as a confection with water or milk. For children under one year the daily dose prescribed may be 334 grains (0.25 gramme); for those of from four to five years, 41⁄2 to 7% grains (0.30 to 0.50

EUCALYPTOL.-EUGEnol.

91

gramme); and for those over five years, 71⁄2 to 114 grains (0.50 to 0.75 gramme).

EUCALYPTOL.

This substance is obtained from the essential oil of several plants of the Eucalyptus genus, and also from other plants. The formula given for eucalyptol is C10H18O.

Physical Properties.-This body, when pure, occurs as a colorless liquid with an odor resembling that of camphor. It boils at from 348.8° to 350.6° F. (176° to 177° C.), and its sp. gr. is 0.930. It crystallizes at 30.2° F. (—1° C.).

Solubility.—Eucalyptol is soluble in alcohol, ether, chloroform, and the fatty oils; it is insoluble in water.

Therapeutic Applications.-This drug possesses marked therapeutic properties, but is chiefly employed externally as an antiseptic in ulcers and as a stimulant in neuralgia and rheumatism. Internally, it has been of advantage in diseases of the respiratory tract, such as pneumonia, pulmonary gangrene, and tuberculosis. has done good in malaria, affections of the urinary tract, and influenza.

It

Administration.—Eucalyptol is best given in capsules or in emulsion internally, or hypodermatically in oil, in doses of 5 minims (0.30 gramme).

EUCALYPTUS ROSTRATA.

This plant occurs upon the market in the form of red gum.

Therapeutic Applications.-This drug is highly recommended in the treatment of seasickness.

Administration.—This medicament is best administered in lozenges, in doses of I grain (0.06 gramme) three or four times a day.

EUGENOL.

This body, a phenol which is yielded by the oil of cloves through oxidation, may be obtained also fr

other essential oils, such as that of cinnamon, bay, pimento, and sassafras. Eugenol is also termed eugenic acid, and is thus chemically constituted: CH3.C2H ̧-(OH)(OCH2). Physical Properties.-Eugenol occurs as an aromatic liquid with a boiling-point of 455° F. (235° C.).

Solubility. This drug is freely soluble in alcohol, but only slightly soluble in water.

Therapeutic Applications.-Although recommended as a febrifuge, this remedy is at present mainly employed as an antiseptic;' as such it has rendered good service, being considered in many instances superior to carbolic acid.

Administration.-The daily dose of eugenol, which can be best administered in alcoholic solutions, is 45 minims (2.80 grammes).

EUONYMIN.

This drug is obtained from the bark and root of Euonymus atropurpureus; its chemical constitution has not been definitely made out.

Physical Properties.-Euonymin is a brown or greenish-brown resinous powder having a slightly bitter taste. Solubility. This drug is soluble in water, but scarcely so in alcohol and ether.

Therapeutic Applications.-Euonymin is of service as a laxative in constipation of hepatic origin due especially to a torpid organ.

Administration. The dose of euonymin is from 1⁄2 to 3 grains (0.03 to 0.18 gramme).

EUPHORBIA PILULIFERA.

Physiological Action.-This drug, in full doses, acts especially as a depressant of the circulation and the res

1 Besides the benzoyl-eugenol (q.v.) another derivative of eugenol is the cinnamyl-eugenol, with a formula of CH ̧.С2H¿(OCH ̧)CO2(CH),CH,, which occurs in colorless crystals, odorless and tasteless, having a boiling-point of 194° to 198.5° F. (90° to 91° C.). Cinnamyl-eugenol, like its co-derivative, is soluble in hot alcohol, ether, chloroform, and acetone. This drug is being used in the treatment of tubercular diseases.

piration, though it is said to also cause irritation of the stomach.

Therapeutic Applications.-This plant has recently been found of value in the treatment of coryza and hay asthma, and has been recommended in emphysema and chronic bronchitis. It has been lauded in the treatment of chronic asthma.

Administration. The preparation used is the fluid extract, the dose of which is given as from 30 to 60 minims (2 to 4 gramines).

Contraindications.-This drug is said to be contraindicated in diseases of the kidney. It is believed that the coloring matter of the plant affects the renal secretions in one way or another, and hence this drug should not be used in kidney troubles except with great caution.

EUPHORIN.

This body is the carbonate of ethyl and phenyl, phenylethylic urethane, or simply phenyl urethane, having a /O,C,H, or CH,NHCOOC2H¿.

formula of CO< NH,CH.

Physical Properties.—Euphorin occurs as a white powder having a slight aromatic odor and a taste resembling that of cloves. Its melting-point is 123.8° F. (51° C.).

Solubility. This drug is soluble in alcohol, but only slightly soluble in water.

Therapeutic Applications.-Euphorin is. recommended as a serviceable antipyretic, antirheumatic, anodyne, and antiseptic in those affections requiring the actions of such drugs. Thus, it has been employed with asserted success in rheumatism, tuberculosis, venereal and other skin disorders, etc. As an antipyretic it has

been tried with success in typhoid fever, appearing to act better when the fever is at its maximum. The defervescence that follows its ingestion is attended with a feeling of warmth and moderate sweating. This drug can be employed in surgical fevers. Its analgesic powers

have been tested with satisfactory results in neuralgia not due to a specific cause, and also in wounds and ulcers. The drug is claimed to be one of the most effective disinfectants in thrush.

Administration.-Euphorin may be given in doses of from 71⁄2 to 15 grains (0.5 to 1 gramme) twice or thrice a day. It can be employed in the pure state as a dusting-powder, and also in the form of an ointment with vaselin or lanolin.

Toxicology.-Euphorin causes no alarming secondary effects; cyanosis is sometimes produced by the drug, but never symptoms of collapse.

EUROPHEN.

Europhen, which must not be confounded with euphorin (q. v.), is the iodo-di-iso-butyl-ortho-cresol or di-iso-butylortho-iodide, said to contain 21.8 per cent. of iodine. It is chemically constituted as follows: 2( 2

CH}CH,O)HI.

Physical Properties.-This drug occurs as an amorphous powder having a yellowish color and an odor resembling that of saffron. It melts at 158° F. (70° C.) and liquefies at 230° F. (110° C.), the liquid appearing of a clear brown color.

Solubility.-Europhen is soluble in alcohol, ether, chloroform, and the oils, but is insoluble in water.

Incompatibility. This drug is incompatible with mercurial preparations and with metallic oxides, as well as with starch and zinc.

Therapeutic Applications.-This remedy is used in all those diseases for which iodoform is employed; over this latter substance europhen has some advantages. It has been found serviceable in lupus, ulcers of the leg, and scrofuloderma. Hypodermatically administered, europhen is said to be beneficial in the treatment of syphilitic disorders.

Administration.-This drug is applied as a dustingpowder or in ointment of the strength of from 5 to 10