Advances in Vision Research, Volume II: Genetic Eye Research in Asia and the PacificGyan Prakash, Takeshi Iwata This second volume continues with a focus on the state of the art in genetic eye research in Asia and the Pacific. Though there has been an explosion of information on genetic eye research in western countries, more than sixty percent of the human genes involved in eye diseases in the Asian and Pacific population remain unknown. However, new efforts and a new awareness have sparked important discussions on the subject, and new plans are being implemented to discover the genes responsible for many eye diseases in the population. The book reviews the latest findings; its content ranges from genetic aspects of human migration to DNA sequence analysis, genome-wide association analysis, and disease phenotypes. The efforts of the Asian Eye Genetic Consortium (AEGC) are also discussed. The book’s editors have been instrumental in developing strategies for discovering the new Asian genes involved in many eye diseases. All chapters were written by leading researchers working on Asian eye genetics from the fields of Human Genetics, Ophthalmology, Molecular Biology, Biochemistry, Sensory Sciences, and Clinical Research. Advances in Vision Research, Volume II will prove to be a major resource for all researchers, clinicians, clinical researchers, and allied eye health professionals with an interest in eye diseases among the Asian population. |
Contents
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eyeGENE A Model for Advancing Research of Rare Inherited Eye Conditions Through Biobanking and Data Sharing | 29 |
Inherited Ocular Disease in the New Zealand Māori Novel Genetic Mechanisms and Founder Effects | 40 |
Genetics of Ocular Diseases in Malaysia | 57 |
Challenges and Opportunities in Genetic Research from the Perspective of a Tertiary Eye Care Hospital in Bangladesh | 70 |
Genetic Research on Ocular Health and Disease in a Population from Nepal | 75 |
Clinical Genetics of Vitelliform Macular Dystrophy An Asian Perspective | 255 |
AdenoAssociated Virus AAVMediated Gene Therapy for Leber Hereditary Optic Neuropathy | 273 |
Stargardt Disease in Asian Population | 279 |
Retinoblastoma Genes in Chinese Studies | 296 |
Genetics of Retinoblastoma Basic Research and Clinical Applications | 313 |
GenotypePhenotype Correlation in Retinal Degenerations | 322 |
CYP1B1 Gene Mutation in Primary Congenital Glaucoma | 337 |
Diabetic Retinopathy Clinical Genetic and Health Economics An Asian Perspective | 345 |
Genetic Eye Research in the Philippines | 85 |
Hereditary Eye Disease in Ningxia Hui Autonomous Region of China | 93 |
Ophthalmic Genetics in India From Tentative Beginnings in the 1980s to Major Achievements in the TwentyFirst Century | 113 |
PanelBased NextGeneration Sequencing for Inherited Retinal Degenerations in Koreans | 120 |
Genetic Disease in Ophthalmology Healthcare and Research Opportunity in Bangladesh | 131 |
Update on the Japan Eye Genetics Consortium JEGC | 137 |
Genetics and Susceptibility of Retinal Eye Diseases in India | 146 |
Unique Patient Populations in Asia for Genetic Eye Research | 169 |
Retina Genes in Chinese | 177 |
Leber Congenital Amaurosis in Asia | 191 |
The Genetics of Inherited Retinal Diseases in the Israeli and Palestinian Populations A Lesson from Populations with High Rates of Consanguinity | 232 |
Occult Macular Dystrophy Miyakes Disease | 249 |
Glaucoma Genes in East Asian Studies | 357 |
Quantitative Trait for Glaucoma | 373 |
Genetics of Exfoliation Syndrome in Asians | 381 |
Proteomics of Neurodegenerative Disorders of the Eye | 392 |
Genomic Approaches to Eye Diseases An Asian Perspective | 403 |
Myopia Genes in Asians | 417 |
Keratoconus Genes in Chinese | 434 |
Granular Corneal Dystrophy Type 2 Prevalence in South Korea Molecular Pathogenesis and Therapeutic Approaches | 449 |
About the Editors | 461 |
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