Advances in Vision Research, Volume II: Genetic Eye Research in Asia and the Pacific

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Gyan Prakash, Takeshi Iwata
Springer, Nov 3, 2018 - Medical - 468 pages

This second volume continues with a focus on the state of the art in genetic eye research in Asia and the Pacific. Though there has been an explosion of information on genetic eye research in western countries, more than sixty percent of the human genes involved in eye diseases in the Asian and Pacific population remain unknown. However, new efforts and a new awareness have sparked important discussions on the subject, and new plans are being implemented to discover the genes responsible for many eye diseases in the population. The book reviews the latest findings; its content ranges from genetic aspects of human migration to DNA sequence analysis, genome-wide association analysis, and disease phenotypes. The efforts of the Asian Eye Genetic Consortium (AEGC) are also discussed. The book’s editors have been instrumental in developing strategies for discovering the new Asian genes involved in many eye diseases. All chapters were written by leading researchers working on Asian eye genetics from the fields of Human Genetics, Ophthalmology, Molecular Biology, Biochemistry, Sensory Sciences, and Clinical Research. Advances in Vision Research, Volume II will prove to be a major resource for all researchers, clinicians, clinical researchers, and allied eye health professionals with an interest in eye diseases among the Asian population.

 

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Contents

Asian Eye Genetics Consortium AEGC The First 5 Years
1
A Bibliometric Analysis of AEGC Scientific Outreach
13
Opportunity for PopulationBased Eye Research in Asia and the Middle East An NGO Perspective
22
eyeGENE A Model for Advancing Research of Rare Inherited Eye Conditions Through Biobanking and Data Sharing
29
Inherited Ocular Disease in the New Zealand Māori Novel Genetic Mechanisms and Founder Effects
40
Genetics of Ocular Diseases in Malaysia
57
Challenges and Opportunities in Genetic Research from the Perspective of a Tertiary Eye Care Hospital in Bangladesh
70
Genetic Research on Ocular Health and Disease in a Population from Nepal
75
Clinical Genetics of Vitelliform Macular Dystrophy An Asian Perspective
255
AdenoAssociated Virus AAVMediated Gene Therapy for Leber Hereditary Optic Neuropathy
273
Stargardt Disease in Asian Population
279
Retinoblastoma Genes in Chinese Studies
296
Genetics of Retinoblastoma Basic Research and Clinical Applications
313
GenotypePhenotype Correlation in Retinal Degenerations
322
CYP1B1 Gene Mutation in Primary Congenital Glaucoma
337
Diabetic Retinopathy Clinical Genetic and Health Economics An Asian Perspective
345

Genetic Eye Research in the Philippines
85
Hereditary Eye Disease in Ningxia Hui Autonomous Region of China
93
Ophthalmic Genetics in India From Tentative Beginnings in the 1980s to Major Achievements in the TwentyFirst Century
113
PanelBased NextGeneration Sequencing for Inherited Retinal Degenerations in Koreans
120
Genetic Disease in Ophthalmology Healthcare and Research Opportunity in Bangladesh
131
Update on the Japan Eye Genetics Consortium JEGC
137
Genetics and Susceptibility of Retinal Eye Diseases in India
146
Unique Patient Populations in Asia for Genetic Eye Research
169
Retina Genes in Chinese
177
Leber Congenital Amaurosis in Asia
191
The Genetics of Inherited Retinal Diseases in the Israeli and Palestinian Populations A Lesson from Populations with High Rates of Consanguinity
232
Occult Macular Dystrophy Miyakes Disease
249
Glaucoma Genes in East Asian Studies
357
Quantitative Trait for Glaucoma
373
Genetics of Exfoliation Syndrome in Asians
381
Proteomics of Neurodegenerative Disorders of the Eye
392
Genomic Approaches to Eye Diseases An Asian Perspective
403
Myopia Genes in Asians
417
Keratoconus Genes in Chinese
434
Granular Corneal Dystrophy Type 2 Prevalence in South Korea Molecular Pathogenesis and Therapeutic Approaches
449
About the Editors
461
Index
465
Copyright

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About the author (2018)

Dr. Gyan Prakash, Director, Office of International Program Activities, National Eye Institute-NIH, Bethesda, MD, USA

Dr. Takeshi Iwata, Director, Molecular and Cellular Biology Division, National Institute of Sensory Organs, Tokyo Medical Center, National Hospital Organization, Tokyo, JAPAN

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