Natural Production of Organohalogen Compounds

Front Cover
Gordon W. Gribble
Springer, Feb 20, 2004 - Science - 314 pages

This book summarizes the state-of-the-art knowledge on naturally occurring organohalogens, of which more than 3700 are documented. The chapters cover all aspects of this field, including the structural diversity and sources of organohalogens, the mechanisms for their formation and biodegradation, the clinical use of dichloroacetate, and the synthesis of the powerful anticancer chlorine-containing cryptophycin. Both biogenic and abiogenic sources of organohalogens are treated, the latter of which include volcanic emissions and abiogenic formation in soil. Halogenation in humans, fungi, and in the ocean are covered in separate chapters. Sources and biosynthesis of the relatively rare natural organofluorines are also discussed in this volume. By better understanding of the role nature plays in the area of organohalogens, we can more intelligently regulate the production, use, and disposal of man-made organohalogen compounds.

 

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Contents

The Global Cycles of the Naturally Occurring Monohalomethanes
17
The Biogeochemistry of Chlorine in Soil
43
Abiotic Formation of Organohalogens During Early Diagenetic Processes
63
Marine Sources of Volatile Organohalogens
85
An Update on Organohalogen Metabolites Produced by Basidiomycetes
102
Volcanic Formation of Halogenated Organic Compounds
121
Occurrence and Biosynthesis
140
Enzymology and Molecular Genetics of Biological Halogenation
171
Phagocyte Enzymes
200
Biotransformation Toxicology and Pharmacogenomics of Dichloroacetate
215
The Natural Destruction of Organohalogen Compounds
235
Cryptophycin Synthesis
265
Subject Index
307
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