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nasal mucous membrane in two girls, aged respectively 14 and 16; in one there was great tendency to bronchial catarrh.

Pharyngitis et laryngitis chron.

One success, in a man, set. 40, with mucous secretion and frequent irritation to cough. After eight days no change was apparent; after fourteen days there was considerable diminution of the morbid state, and after three weeks all the mucous secretion had disappeared; there was only some irritation to cough when he drank anything cold. After another fourteen days some mucous secretion recurred with slight redness from injection, which again disappeared on continuing the Mucin.

Catarrh, phar. chron.—One success, two failures.

The success was in a woman, set. 26, otherwise healthy. The affection, which had lasted a year, was complicated with dry tickling cough and a constant dry feeling with visible dryness of the faucial mucous membrane (some mucous secretion in the morning). Mucin was of temporary use in the cough irritation. Acid, oxalic, improved the catarrh, but not permanently. Acid, lact. was of no use. Mucin cured in about ten weeks, no relapse had occurred after three months.

One failure occurred in a woman, set. 30, who afterwards got Acid, oxal., but did not return; the other failure was a woman set. 40, whose case was interrupted by the occurrence of rheumatism.

Otitis tned. chron.—One success, two failures.

The success was a boy, set. 4, who had taken Allantoin for four weeks previously without benefit.

The negative effects were in a woman, set. 26 (in whom Acid, lact. was also useless), and a boy, set. 12, who for eleven years was said to have suffered from diminished power of hearing. Acid. lact.—usually a good remedy in catarrh of the middle ear —was powerless in this case. Under the use of PJienylacetic acid the hearing power was considerably improved. The patient is still under treatment.

Catarrh, branch, acut. without fever.—One success (cure by nature?).

Catarrh, branch, for three weeks.—One success in a man, 8et. 40—whitish expectoration.

Catarrh, bronch. chron.—Two successes.

One was a child, of 8 months, mucous rales audible at a distance; the other was a woman, SBt. 42, with very copious, whitish expectoration.

Neurin (chs)3nc2h4(ho)2

occurs:

In swine and ox bile; is the product of decomposition of lecithen, which may be regarded as a neurin salt of glycerinphosphoric acid. Liebreich says he has found in urine a small quantity of an organic base resembling the Neurin obtained by him from the decomposition of protagon with baryta water, and which may perhaps be a product of the oxydation of the latter.

Neurin is a deliquescent, yellowish-white mass, with strong alkaline reaction.

For therapeutic use I diluted it with alcohol to the 4th centesimal attenuation, and this I used almost exclusively. Dose as with Urea.

Neurin seems to me to have the power of lowering the morbidly increased activity of the sensory nervous system in certain cases. Is it perhaps produced in increased quantity in such affections? So long as we know nothing about the chemistry of the nerves than that Gescheidlin has observed an acid reaction during the increased activity, the data for discovering the curative power are very uncertain.

I have noted the following:

Agrypnia.—Three successes. This diagnosis must be taken cum grano salis. Obviously a curative action can only be expected where a more or less primary alteration of the cerebral position is the cause of the sleeplessness.

The following cases may serve as illustrations:

Mrs. Deter, set. 35, had suffered for three years from sleeplessness. She had a slight chronic metritis. She was often whole nights without sleep, and at last only slept for a few hours, and then could be awoke by the slightest noise, and could not again fall asleep. Her scanty sleep was moreover disturbed by anxious dreams. She had no objective morbid affection besides the metritis. Chloral hi/drat, Morphia, and other narcotics produced sleep, from which she awoke much exhausted. Neurin °°4, five drops three times a day. After ten days I was informed that during all that time she had slept well. The medicine was continued for five months, in which time the malady was removed with a few relapses. During this time the symptoms of metritis were very much improved. {Neurin readily changes into trimethylamin, the gas that has a strong odour of herring brine.)

Mr. A—, set. 27, complained for some months, as a consequence of emotional disturbance, of deficient sleep, palpitation of the heart (which only came on at night in bed), and great liability to start, &c. Neurin °°4s, five drops four times a day, caused speedy improvement, and a complete cure in seven weeks.

Miss Kraft, «t. 24, in other respects quite well, suffered for eight years from the following attacks: every four to six weeks, independently of the catamenia, every night, for three or four successive days, a few minutes after falling asleep she started up in great anxiety, so that she jumped up and clutched about her without losing consciousness. These paroxysms returned whenever she fell asleep again, about twenty times in one night. Besides this she was troubled with absolute sleeplessness for one year and a half, which went off on changing her climate. Allopathic doses of Iron had no effect. There were no chlorotic symptoms nor any other organic affection. Neurin 0O4, five drops three times a day, produced quiet sleep for six hours on the second night. This good effect was maintained with unimportant relapses for ten weeks while taking the medicine. But the attacks above described have not as yet been much benefited.

Cephalalgia nervosa.—Four successes, three failures.

Clara Hortke,set. 10, suffered for eight weeks from headache with occasional hot feeling in the head, aggravated by corporeal exertion. Neurin O04, three drops every two hours, effected speedy improvement. I am unable to ascertain if the disease was cured.

Mrs. Prange, at. 33, has for two or three months suffered from headache in the occiput, temples and ears, otherwise healthy. Neurin. After nine days the pain was inconsiderable; I cannot speak as to the further effects.

Anna Kohler, set. 14, lives in a damp cellar, and has suffered for several weeks from nervous headaches, vertigo, anorexia, chilliness. No gastric symptoms. Neurin. In ten days the headache was much better, and the anorexia improved. .

Emma Schmidt, set. 21, has been troubled for six weeks by a painful feeling of tension in forehead, which is aggravated by slight exertion. Neurin. Rapid improvement; cure in four weeks.

The failures were the following:

Adolf Schwenk, set. 13, has been suffering for eight weeks continuously from violent pains which spread from the nape all over the head, seldom limited to the frontal region. In the open air they gave place to a tiresome confusion of head, but immediately returned on entering a room. Exhaustion; moderate appetite. Sleep good. No objective symptoms. Neurin °°4, and after three weeks Protagon °°3, without benefit.

Mrs. Th—, set. 60, has been troubled with headache for a year, which occurs after moderate exertion, external cold, when walking in rainy, windy, cold weather, and often increases so as to cause vomiting. The pain is alleviated when lying, warmth has no effect on it; the head feels cold. Neurin °°4 remained without effect. But another remedy, of which I shall speak hereafter, cured.

A man, set. 26, with decided migraine coming on every four or five weeks and ending in vomiting, took Neurin °°4 for eight weeks without benefit, three times a day in doses of five drops. I shall also hereafter tell how he was cured.

Vertigo.—Three successes.

Heiner, engine driver, has suffered for a long time, but for eight weeks in increased intensity, from a giddy feeling, aggravated in the open air, and on one occasion causing him to fall Insensible. Along with it he has occasionally pains in the sinciput. No other symptoms pointing to threatening apoplexy or spinal disease. Neurin °°4 removed all the symptoms completely in two or three weeks. After six weeks he had a slight relapse, for which Neurin °°4 was repeated. I have heard nothing since then of him.

Mrs. Wieprecht, set. 67, was affected for months with vertigo, especially when walking, sleeplessness and palpitation of heart. Mental trouble was assigned as the cause. With the exception of gastric catarrh, which had no relation to the intensity of the cerebral affection, she seemed well, barring moderate weakness of old age. Neurin gave relief in a few days, and in five or six weeks, she was free from the nervous irritation.

Mr. Beuter, set. 46, suffered from vertigo for fourteen days, which during the last eight days had increased to loss of consciousness and falling. There was congestion of blood to the head; otherwise healthy. A brother suffered from apoplexy. Neurin °°4, at first every hour, and after two days five drops four times a day, removed the vertigo in less than eight days. Ten weeks later he had no relapse.

Catarrh, laryng. c. irritat. nerv.—One success.

Mrs. Geridin has suffered for three years on catching cold, from violent tickling cough, without hoarseness, which does not go off spontaneously. In the larynx there remains a permanent irritation to cough. The ordinary allopathic remedies Morphia, extr. Hyos., Chloral hydrat used generally to relieve her. On account of extraordinary irritability of the throat laryngoscopy could with difficulty be employed. The vocal cords and walls appeared normal, the epiglottis only was somewhat injected. Under Neurin, five drops four times a day, the patient was rapidly cured. A year afterwards there was a relapse.Tor which Kreatin was used without benefit.

Tussis convulsiv.—Two successes, two failures.

Gastralgia.—Nine successes, three failures.

In much the greater number of this affection, some physical pathological cause can be diagnosed, so that the cardialgia can only be regarded as a symptom. Hence the curative action of Neurin can only come into play when there is an abnormal sensitiveness of the sensory nerves involved. In order to show the sphere of affection of Neurin in these affections, I will relate the following cases:

Mrs. Schulz, of healthy appearance, set. 32, has suffered for three months, especially after getting cold feet or eating indigestible food, from violent cardialgic pains, which extend to the back, and cause her to crouch together. Appetite good,

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