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effected restitutio in integrum. Later I observed in one case that Xanthin and Hippuric acid in alternation (in pharyngitis acuta) was of no use, whereas in the same case Hippuric acid given alone gave rapid relief.
Pharyngitis chron.—One success.
Epiglottitis chron.—One success in a girl, aet. 20.
Great injection of the epiglottis and of the entrance to the larynx, constant sore feeling in the region of the larynx, dry feeling in the larynx. The treatment by an allopath with Iodine and Nitrate of Silver locally applied had been unsuccessful.
Laryngitis acuta.—One success, one failure.
In addition to these I may relate the following cases:—A gentleman, about 60 years old, suffered from bronchial catarrh with incessant tickling cough. Tannin did no good ; previously touching with Argent. nit. was of use for the laryngeal irritation. Hippuric acid oc4, three drops every hour or two hours removed the continued irritation to cough very rapidly.
A woman, set. 40, complained of dry tickling cough without hoarseness. Hippuric acid for fourteen days had no effect, on giving Asparagin acid the cough, that had lasted ten weeks, disappeared in five weeks.
Bronchitis acuta with pleuritic stitches in a woman, aet. 25. —One failure.
Otitis med. acuta.—One success.
A man affected with chronic catarrh of the middle ear, had for ten days an acute exacerbation with the most violent pains, which were allayed; they were not alleviated by ten days of allopathic treatment. He frequently suffered from rheumatism. Hippuric acid made him quickly better.
Otitis med. chron.—One success.
A man, a?t. 40, had suffered for six years from chronic purulent catarrh of the middle ear; he was also troubled with chronic rheumatism. First the rheumatism improved, then the aural affection.
Rheumatismus acutus (not articular).—One success, two failures.
One of the failures was a woman, who for ten days complained of violent wandering pains over and through the whole head. Allantoin relieved in two days. In the second case, Succinic acid, Xanthin and Hypoxanthin were useless; I gave Allantoin, but was unable to ascertain the result.
Rheumatismus chron.—Five successes, one failure. In this case there were exudations in the sheaths of the flexor tendons. (Is still under treatment.)
A man, at. 25, had suffered from sciatica seven weeks. Allopathic treatment was employed without result; three days after giving Hippuric acid there was improvement, in three weeks complete recovery.
Polyarthritis chron.—One failure.
Eczema cruris chron., with great infiltration and intense pains.—One failure, Chlorrhodin acid cured. Previously Xanthin had been given without effect. (Vide under Xanthin.)
Condylomata lata in a man, aet. 22. A failure; Xanthin also failed.
I may mention the following in respect to Hippuric acid. Patients, both children and adults, treated with it (in the 4th cent. dil.), complained of more or less violent diarrhoea as the effect of the medicine. At first I paid no attention to these complaints, but at length could not avoid doing so as they increased in a striking manner. In other cases the patients said that after using this remedy their bowels became more regular.
A. Physiologically. According to Gusserow and Herman Allantoin occurs in small quantities in healthy human urine. Others have only found it in the urine of pregnant women, in the fluid contents of the pregnant womb, and in the urine of new born infants during the first week after birth, in the allantoic fluid of cows, in the urine of young calves as long as they are sucking or fed with milk. Schotten found it in human urine after taking Tannic acid in large quantities; Meissner and Jolly found it in the urine of dogs after taking very fat food with Succinate of soda; it has also been observed in the urine of dogs fed with Uric acid. It is formed from Uric acid treated with Superoxide of lead, Cyanide of Potassium and Iron, or Permanganate of Potash. It seems to be a preliminary stage of Urea.
Stadeler and Frierichs found it in the urine of dogs after impeded respiration, Kohler in the urine of rabbits after injection of oil into the lungs.
Allantoin crystallises in transparent colourless prisms, is without taste or odour. It dissolves in 160 parts of cold water, more readily in hot water. Hot alcohol dissolves it, but on cooling it is mostly precipitated. Insoluble in ether.
I gave it in the same way as Xanthin.
I noted the following cases:
Conjunctivitis chron.—One failure.
Keratitis scrofulosa.—Three successes, one failure.
The three successful cases were the following:
Paul Voigt, set. 8, had been treated without benefit allopathically for a quarter of a year before coming under my care. He was somewhat improved in eight days under Allantoin -°°5, and in five weeks cured all but dimness of the cornea. Treatment not continued.
Franz Knaust, set. 8, had been treated unsuccessfully homoeopathically for four weeks for a keratitis of the left eye and conjunctivitis of the right eye, before he came under my care. Left eyelid much swollen and inflamed, great photophobia, cornea smoky. Allant. -°°5, three drops every two hours. Next day improvement; after eight days, eyelids normal, and after sixteen days all pathological appearances gone except slight redness of lids. The disease had lasted five weeks before I saw it.
Anna Dagesell, set. 1, had suffered for four weeks from ophth. scrof., for which Xanthin had been used without benefit, whereupon it was changed for Allantoin. In eight days improvement commenced, complete cure followed in nine weeks, the medicine being continued all the time.
Tonsillitis acuta.—One success.
Rheumatism, acut. et chron.—Twelve successes, three failures, one of which I will give in .detail.
Mrs. X—, age about 30, functions normal except violent menstrual spasms (cause unknown), has suffered from her sixth year occasionally from very violent rheumatic pains in both upper arms, from the shoulder to the elbow-joint, which even in her best times are aggravated to a painful paralytic feeling by long continued movement of the arms, e.g. by knitting, playing the piano, &c. She was treated allopathically with Iron for years without relief, the induced current was also ineffectual, the mud baths of Elster and the brine baths of Pyrmont were of only temporary benefit. The constant current was employed by me with temporary relief; the following medicines were given without the slightest benefit: Rhus tox., Puis., Caust., Rhodod., Bryon., high and low, XantMn, Glycocoll, Glycogen, Allantoin. At last I employed, for six weeks, methodical massage by a professional rubber with the same negative result. After I had done my utmost for two years, she put herself under the treatment of an allopathic physician. He prescribed Salicylic acid. In a few > days improvement commenced, which on continuing the acid has remained till now, after half a year, with some slight relapses.
Mucin, C4g.s4Hg.8iNg.50O35.j5 (Eichwald).
In the mucous glands, saliva, vitreous body, synovia, thyroid, lymphatic glands, in the nuclei of the connective tissue cells, connective-tissue substance (pre-existent?), in the embryonic tendons, in the gelatinous substance of the navel cord. Normal urine always contains traces of mucin in solution.
Increased in catarrh of nose, mouth, fauces, respiratory tubes, intestine, urethra, vagina, uterus. Is found in the mucous softening of bones, cartilage, connective tissue, in the cartilages of the symphyses, and the intervertebral cartilage as senile alteration, in struma cystica, in myxoma, sarcoma, fibroids, colloid tumours, in the pus of suppurating mucous membranes. Increased in the urine (according to Reissner), in acute febrile states of the most various kinds, also in pneumonia, typhus, ague, catarrh of respiratory and intestinal tracts, meningitis, acute mania, and epileptic attacks with excitement of the vascular system, &c.
Mucin swells out in water without dissolving. Dried under the air-pump it is a greyish-brown, hard, rather brittle mass, which rather hinders its swelling in water.
If my 3rd maxim were of general application Mucin must be a true panacea for the whole tribe of catarrhs, for malignant tumours, struma, gonorrhoea, &c. But this is not the case, which proves that this maxim must be received with caution. It is probable also that this remedy must be further tested, or that the chemical investigations respecting this substance require a fundamental revision. The reports concerning its atomic relations do not agree. At first I used, following Stadeler's directions, that from the submaxillary gland of the ox, then, guided by Eichwald, the preparation made from vine snails, but I am not yet able to establish any difference between them.
For its medicinal preparation I employed the preparation dried under the air-pump, and give the 4th dilution prepared from the 3rd centesimal trituration.
Polypus mucos. of the nasal mucous membrane.—Two successes, one failure.
I did not see complete cures as the patients, a youth of 17 and a girl of 5, did not reappear after improvement had -set in. The failure was a man of 40, who ceased attendance after taking Mucin without benefit for four weeks, he had previously taken Cholesterin for three months with little or no improvement.
Rhinitis chron.—Two successes. Dry swelling of the