BRAIN AND NERVE FOOD. By Druggists or Mail, $1.00. F. CROSBY CO., 56 West 25th Street, New York City. PELLETIER'S CAPSULES OF SULPHATE OF QUININE. Prepared by MESSRS. ARMET DE LISLE & CIE., successors of PELLETIER, DELONDRE & LEVAILLANT, with ir renowned "QUININE DES TROIS CACHETS." These Capsules are very thin, transparent, and dissolve ily in the stomach; they contain each 10 centigrammes (over 1 grain English) of the pure Sulphate of Quinine in silky stals, and are capable of indefinite preservation. SOLD IN BOTTLES OF TEN OR TWENTY CAPSULES. General Depot: PARIS, RIGAUD & DUSART, S Rue Vivienne. New York: E. FOUGERA & CO., Importing Pharmacists. Syr: Hypophos: Comp: C. P. DR. WADSWORTH'S Uterine Elevator. Made of India Rubber, without lead, is the most complete, e best adapted, affords more relief, gives better results, et ses of Prolapsus Uteri, and Displacements of the Tomb, than all other Pessaries and Supporters combined. O say thousands of Physicians from Canada to Texas. Pamphlets describing the Instrument, also Price List, sent application. H. H. BURRINGTON, Chemist & Druggist, Sole Proprietor, Providence, R. L. lso for sale by dealers in Surgical Instruments generally. N.B.-The public are cautioned against using the above Trade Marks. FISK & ARNOLD, MANUFACTURERS OF ARTIFICIAL LIMBS, False Calves, Silk, Elastic, Wool, and Cotton No. 8 Hamilton Place, Boston, Officers and soldiers furnished on government account SAMUEL H. DURGIN, M. D., Lecturer on Hygiene. JOSEPH W. WARREN, M. D., Assistant in Physiology. A New Building has just been completed at a cost of more than a quarter of a million of dollars. Its numerous apartments are spacious, well lighted provided with carefully contrived apparatus for heating and ventilation. The comfort and convenience of the students have been constantly borne in m the arrangement of rooms, the construction of seats, and in the furnishing of the various laboratories, halls for lectures, and rooms for recitations, studies conversation. The building is devoted to laboratory instruction and didactic teaching, while the general and special clinics take place at the various ba and dispensaries. Greatly enlarged and improved facilities are offered at the Massachusetts General Hospital and the Boston Dispensary, both of which tutions have recently constructed buildings to meet the constantly increasing demands for their usefulness. Every candidate for admission not holding a degree in arts or science must pass a written examination on entrance to this School, in English, Latin, Physi and any one of the following subjects: French, German, Elements of Algebra or of Plane Geometry, Botany. The admission examination for 1884-83 = held June 23d, at Boston, June 26th, at Exeter, Andover, New York, Philadelphia, Chicago, Cincinnati, St. Louis, and San Francisco; on September 20 Boston only. Instruction is given by lectures, recitations, clinical teaching, and practical exercises, distributed throughout the academic year. In the subjects of Anat Histology, Chemistry and, Pathological Anatomy, laboratory work is largely substituted for, or added to, the usual methods of instruction. The year begin September 25, 1884, and ends on the last Wednesday in June, 1885, and is divided into two equal terms. Students are divided into four classes, according to their time of study and proficiency, and during their last year will receive largely increased opportun for instruction in the special branches mentioned. Students who began their professional studies elsewhere may be admitted to advanced standing: persons who apply for admission to the advanced classes must pass an examination in the branches already pursued by the class to which they seek admisie Although the course of study recommended by the Faculty covers four years, until further notice the degree of Doctor of Medicine will continue to be upon the completion of three years of study, to be as ample and full as heretofore. The degree of Doctor of Medicine cum laude will be given to card lar who have pursued a complete four years' course, and obtained an average of 75 per cent. upon all the examinations of this course. In addition to the ord degree of Doctor of Medicine as hitherto obtained, a certificate of attendance on the studies of the fourth year wiffl be given to such students desiring shall have attended the course, and have passed a satisfactory examination in the studies of the same. ORDER OF STUDIES. — FOUR YEARS' COURSE. -Anatomy, Physiology, and General Chemistry. For the First Year. For the Second Year. - Practical and Topographical Anatomy, Medical Chemistry, Materia Medica, Pathological Anatomy, Clinical Medicine, Surgery For the First Year. - Anatomy, Physiology, and General Chemistry. For the Second Year. ical Surgery. Practical and Topographical Anatomy, Medical Chemistry, Materia Medica, Pathological Anatomy, Clinical Medicine, and Ch For the Third Year. Therapeutics, Obstetrics, Theory and Practice of Medicine, Clinical Medicine, Surgery, Clinical Surgery, Ophthalmology, De matology, Syphilis, Otology, Laryngology, Mental Diseases, Diseases of the Nervous System, Diseases of Women, Diseases of Children, Forensic Medicine ANNUAL EXAMINATIONS. At the end of the first year- Anatomy, Physiology, and General Chemistry. End of second year - Topographical Anatomy, Medical Chemistry, Materia Medica, and Pathological Anatomy. End of third year-Therapeutics, Obstetrics, Theory and Practice of Medicine, Surgery. (Students of the three years' course are also examined in Clinical Medicine and Clinical Surgery.) End of fourth year- Ophthalmology, Otology, Dermatology, Syphilis, Laryngology, Mental Diseases, Diseases of the Nervous System, Diseases of Women, Diseases of Children, Obstetrics, Clinical and Operative Obstetrics, Clinical Medicine, Clinical and Operative Surgery, Forensic Medicine. Examinations in all subjects are also held before the opening of the School, beginning September 26th. REQUIREMENTS FOR A DEGREE. Every candidate must be twenty-one years of age; must have studied medicine three or four full years, have spent af least one continuous year at this School, have passed a written examination upon all the prescribed studies of the course taken, and have presented a thesis. COURSE FOR GRADUATES. For the purpose of affording to those already Graduates of Medicine additional facilities for pursuing clinical, laboratory, and other studies, the Faculty has established a course which comprises all of the special subjects of the fourth year in addition to private instruction in Histler, Physiology, Medical Chemistry, and Pathological Anatomy. Any or all branches may be pursued If the full fee is paid, the privilege of attending ar d the other exercises of the Medical School, the use of the laboratories and library, and all other rights accorded by the University will be granted. Gracates of other Medical Schools who may desire to obtain the degree of M. D. at this University will be admitted to examination for this degree after a year's study in the Graduates' Course. Examination on entrance not required. FEES. For Matriculation, $5; for the year, $200; for one term alone, $120; for Graduation, $30. For Graduates' Course, the fee for one year is $200; for one Tera, $120; and for single courses such fees as are specified in the Catalogue. Payment in advance, or if a bond is filed, at the end of the term. THE BOSTON 1884 * COLLEGE LIBRARY Medical and Surgical The Boston Medical and Surgical Journal is published weekly by Houghton, Mifflin & Co., 4 Park St., Boston, where subscriptions are received and single copies of the Journal are always for sale. See Index to Advertisements, page 23, FIFTH YEAR OF CLINICAL COURSES OF MEDICAL INSTRUCTION The following Courses in Practical Medicine and Surgery are offered to Graduates and Students of Medicine for the sumer of 1884: Wednesday, and Friday. INICAL MEDICINE. At the Boston City Hospital. Mondays, Wednesdays, and SYPHILIS AND VENEREAL DISEASES. At the Boston Dispensary. Monday, J. B. SWIFT, M. D. At the Boston Dispensary. Daily. DISEASES OF THE THROAT. At the Boston Dispensary. Monday, Wednesday, and The courses will begin about July 1st, and continue in general six weeks. Each class is limited to a small number, in order that the cases may be carefully examined and fully understood. Applicants, to have a claim to any place, must have applied by mail or in person to the Secretary and paid him the fee for such course. FRANCIS H. WILLIAMS, M. D., SECRETARY. 100 BOYLSTON ST., BOSTON, May 8, 1884. Entered at the Post Office at Boston as second-class matter. Professional Notices. DR. WALTER CHANNING will receive a few cases of Mental and Nervous Diseases at Brookline. P. O. address, Brookline, Mass. Office in Boston, 146 Boylston St. Office Hours, 12 to 1. From June 1st to October 1st, in Boston by appointment only. DR. C. H. COBB Will receive a few Lying-In Cases at 358 Columbus Avenue. Office Hours: Before 9 A. M, 2 to 4 and 6 to 7 P. M. Telephone No 4882. A few Invalids will also be accommodated DR. NORTON FOLSOM Пlas removed, and will meet these desiring to consult him in cases of Mental Disease at No. 15 Pemberton Square, from 11 to 1 o'clock daily, or elsewhere by appointment. Residence, 19 Berkeley St., Cambridge. Tel. ephone 7014. DR. IRA RUSSELL, Assisted by his son, DR. F. W. RUSSELL, receives patients into his "Family Home," WINCHENDON, MASS., for the treatment of Nervous and Mental Diseases. DR. GEO. B. TWITCHELL, for the Insane, will receive into his family a few cases President of the Board of Trustees, N. II. Asylum of MENTAL or NERVOUS DISEASES. P. O. address, KEENE, N. H HOSPITAL. Very many physicians recommend it as a highly agreeable tonic and appetizer. It MASSACHUSETTS nourishes and invigorates the tired brain and body, imparts renewed energy and vitality, and always enlivens the functions. TONIC FOR OVERWORKED MEN. Dr. J. C. WILSON, Philadelphia, Pa., says: "I have used it as a general tonic, and in particular in the debility and dyspepsia of overworked men, with satisfactory results." AS AN APPETIZER. Dr. MORRIS GIBBS, Howard City, Mich., [MAY 8, 181 SUCCESSOR WANTED. A live country practice (actual varnings last th years, besides three months off duty, $9.0063 nished house, with wood-house, a year's ful f house. barn, and good road outfit, will be truferred t thorough practitioner on equitable terms. Lo favorable to lung troubles. Weak competition: pr resque surroundings; good roads. State credentia, ital at command, and address at once" ADIRONDA care Boston Medical and Surgical Journal. FOR SALE A Physician's Country Practice and Real Estate thriving agricultural town in Massachusetts, & 874) miles respectively from cities of 30,000 and 50000 itants. Good practice, little competition. Well arma house and stable Furnace. ice-house, etc. Good Investigation desired. Address S. F., care of Boston Meh ical and-Sur ical Journal. DR. MARTIN'S VACCINE VIRUS, PRICE REDUCED. True Animal Vaccine Virus (Beaugency Stock 15 Large "Lancet Ivory Points......... 7 Large "Lancet " Ivory Points... All Virus fully warranted. DR. HENRY A. MARTIN & SON Single points (20 cents each) can be obtained of BRIGHAM, at the Medical Library, No. 19 Boylster I Dr. Brigham, T. Metcalf & Co., and Leh Greene are the only agents we have ever had in Bo No Virus ours unless package bratt GENERAL facsimile of our signature. Warren Triennial Prize, $450. "On some subject in Physiology, Surgery, or Pathological Anatomy." Dissertations to be forwarded on or before February 1, 1886. For further particulars address J. H. WHITTEMORE, M. D BOSTON, May, 1883. Resident Physician F. M. LORING, PHARMACIST, 655 Tremont Street, Boston. DISPENSING PHYSICIANS' PRESCRIPTIONS A SPECIALTY. All the preparations of the New Pharmacopoeia, and re. liable foreign and domestic remedies, constantly on hand. WANTED. A Graduate of Harvard Medical School, with considerable experience, wishes the position of Assistant to a practicing physician: in the vicinity of Boston preferred. Address" DOCTOR," Office of the Boston Medical and Surgical Journal, stating terms, etc. Second and much Enlarged Edition. says: "I am greatly pleased with it as a tonic; The Processes of Reproduction. it is an agreeable and a good appetizer." FOR OVERWORKED FEMALES. Dr. J. P. COWAN, Ashland, O., says: "My trial of it has been rather satisfactory as a nerve tonic, as well also as in dyspeptic conditions of the stomach, with general debility, such as we find in overworked females, with nervous headache, and its accompaniments." By the late PROF. G. B. ERCOLANI, of Bologna. Translated by HENRY O. MARCY, A. M., M. D., of Boston. In two handsome volumes, one a quarto Atlas of Illustrations finely engraved by BETTINI and reproduced in heliotype. upon The original investigations of Professor Ercolani the Histology, Physiology, and Pathology of Reproducof the present generation. tion have builded for him a reputation second to few men The first edition received the highest commendation from the medical profession, journals, and scientists. The present edition is enlarged by more than one hundred pages devoted to pathological conditions, besides a review in extenso of the entire subject written just prior to the death of the author. Price, $6.00. Published by HOUGHTON, MIFFLIN & CO., BOSTON, MASS. Madame La Chapelle's "Health Preserver," And REVERSE CORSET for preventing and overcoming Uterine disease. Preeminently useful during Pregnancy. Especially adapted to treatment of Functional Derangement. It affords immediate satisfaction. Heat and pain in back and pelvis, prolapsed bowels, ovarian weakness, troubles of the Bladder, and attendant reflex troubles of Heart, Brain, Stomach, and Liver, are relieved by its application. Every one made to order, from glove kid and calf. In measuring give exact size (under all clothing) of Waist; Abdomen at Umbilicus: Ilips, largest part; Thigh and length from Waist to Pubes. Retail price, with Leggings, $15, to Physicians, $10: without Leggings, $12, to Physicians, $8. Send for Circulars and Measure Cards. Measurement must be accu Original Articles. MALIGNANT PUSTULE.' BY W. S. JANNEY, M. D. My remarks to-night will be on the clinical history of four cases of malignant pustule, which have come under my observation at various times during thirty years of practice. The synonyms of malignant pustule, as given by various authors, are: Contagious carbuncle, malignant carbuncle, anthrax, and charbon; other names are used to designate the more diffused and general forms of the disease. It is defined to be a specific contagious disease, communicated to man from disease of horned cattle, horses, sheep, and other herbivora, and known as splenic fever, and due to the presence in the system of the bacillus anthracis of Cohen, or bacteridium of Davaine. The local or external form of the affection, malignant pustule proper, is a carbunculous swelling having specific characters, attended with more or less intense surrounding inflammatory oedema; constitutional symptoms may be slight or severe, and the disease is often fatal. The symptoms and course of malignant pustule vary greatly with the form of disease. Authors describe at least three distinct forms: First, malignant pustule or carbuncle proper, the form from which the names of charbon and anthrax are derived; usually it occurs as a primary lesion due to direct inoculation; the seat is either on the face, neck, hands, or arms, those parts most exposed to inoculation. Second, malignant anthrax, oedema, without definite pustule, corresponds in the main with malignant pustule proper. The eyelids are the parts most frequently affected, but it may occur elsewere. Third, internal anthrax; differs greatly from external, and may be general, having no special lesion or accompanied by local affection; usually pulmonary or gastro-intestinal. The cases that I wish to report to-night come under the form of malignant pustule proper. the 21st. On the morning of the 23d respiration was 30, pulse 130, tongue brown and dry; the cheek was of dark gangrenous color, extending to the lower margin of lower jaw, and also backward, involving the parotid region and right ear, to near the posterior median line of the neck; dark-red streaks extending over the shoulder to the right arm; patient becoming rapidly comatose, and died at two P. M. on the 23d, being fiftyeight hours after first noticing pimple on his face. The inflammation and oedema did not extend over the median line of the face or back of the neck. She The second case that came under my care was :Mrs. R., residing at her country seat in the suburbs of this city, thirty-two years of age, married, the mother of three healthy children, and of previous good health. She noticed September 17, 1876, a small pimple on the right side of the face, one half inch below the lower lip, and slightly to the right of the median line. From her description of how it commenced, she informed me that her first intimation of anything being the matter was a persistent itching sensation, and on rubbing it she felt a small circumscribed induration, which was in the skin, and was not noticeable. continued rubbing it to allay the itching; in a few hours she noticed a slight elevation of the skin, conical in form, and the size of an ordinary pin-head, which increased during the day. Slept well during the night, and on the following morning, the 18th, she noticed the papule had increased in size, and was vesicular, containing a dark-colored fluid. The itching continued, and on rubbing it she ruptured the vesicle, and from that time she had a burning, itching pain in the pustule. I saw Mrs. R. on the morning of the 18th of September; she was sitting in her room and did not consider herself sick; had slight headache; was nervous, and spoke of a premonition of impending sickness or calamity. She had an anxious expression; retraction of the eyelids, giving her a staring expression. Tongue slightly coated with a light yellow coat; temperature 99°, respiration normal, pulse 80; constipated, and urine scauty; on her face, half an inch below the right side of the lower lip, and half an inch to the right of the median line, was a pustule of the size of a split pea, with an indurated base half an inch in diameter, of a dark-red color. The apex of the pustule was denuded of cuticle, and of a dark-brown color, not sensitive to pressure; no lines or streaks of inflammation extending from the pustule; no oedema of face. On the evening of the 18th temperature was 100, pulse 110, respiration 22; tongue coated and dry; streaks or lines of a dark red color, extending from the right side of pustule in a line of the inferior maxilla, curving up Mr. H., residing in Hopewell township, Mercer County, N. J., a farmer, aged sixty; previous to the attack general health good. On the morning of September 20, 1866, Mr. H. noticed a small pimple ou his right cheek, immediately over the infra-orbital foramen. During the day it was slightly painful, and during the night the apex became vesicular, with great itching and burning, which continued to increase until the follow-wards towards the right ear; right half of lower lip ing morning, when I first saw him. The face presented the following appearance: a small pustule, one eighth inch in diameter, situated as above stated, with a denuded apex of a dark-brown color, and an areola of one half an inch in diameter, of a dark red color, surrounding the base of the pustule, and not sensitive to touch; pulse 78, respiration 20, tongue slightly coated, and bowels constipated. During the day the temperature increased. Pulse in the evening 100, respiration 22. Side of face up to this time had become very much swollen, with red streaks extending to the neck; slightly delirious; tongue dry. Free crucial incisions were made in the pustule. Delirious through the night of Read before the Philadelphia County Medical Society, April 9, 1884. swollen, and of a dark-red color, which, on pressure, imparted a nodulated condition; dark-red streaks extending from the lip, curving upwards to the integument over the malar process. The skin and underlying tissues between the base of the pustule and the indurated lip retained their normal color and consistence. Complained of severe lancinating pain over right half of face and shoulder. Morning of the 19th, temperature 101, pulse 124, respiration 24; tongue dry; sordes on teeth; the areola around the pustule not so red; no discharge from pustule; dry and dark in color. The lower right half of lip showing dark gangrenous patches; right half of upper lip swollen, of a dark purple color, hard and nodulated. The right half of the face, |