Response Variability to Psychotropic DrugsW. Janke |
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Page 3
... drug action . The phenomena and mechanisms of absorption , distri- bution , metabolism , and elimination of psychotropic drugs are described . In addition to differences in drug absorption due to sex , age , and bo- dy weight ...
... drug action . The phenomena and mechanisms of absorption , distri- bution , metabolism , and elimination of psychotropic drugs are described . In addition to differences in drug absorption due to sex , age , and bo- dy weight ...
Page 21
W. Janke. 2.4 Factors Affecting Protein Binding and Metabolism of Drugs 2.4.1 Relevance of changes in protein binding ... drug rather than to the individual . Increased binding will en- hance hepatic clearance ( Alvan , 1978 ) . But ...
W. Janke. 2.4 Factors Affecting Protein Binding and Metabolism of Drugs 2.4.1 Relevance of changes in protein binding ... drug rather than to the individual . Increased binding will en- hance hepatic clearance ( Alvan , 1978 ) . But ...
Page 22
... drug metabolizing enzymes . This may result in two genetically distinct subtypes of the same enzyme showing ... drug metabolism has been investigated and re- viewed by several authors with respect to the developing organism as ...
... drug metabolizing enzymes . This may result in two genetically distinct subtypes of the same enzyme showing ... drug metabolism has been investigated and re- viewed by several authors with respect to the developing organism as ...
Contents
Some basic principles and their influence | 3 |
Drug Response Variability Overview of Contributing Factors | 31 |
Debus | 62 |
Copyright | |
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activity administration adrenergic drugs alcohol amitriptyline analysis antidepressant anxiety arousal behavior chlordiazepoxide chlorpromazine cigarettes smoked Claridge Clin clinical concentration correlation Debus depressant drugs depressed patients diazepam DiMascio dose drug effects drug metabolism drug postulate drug response drug tolerance effects of drugs emotional responses environmental enzyme evidence experiment experimental extraverts females genetic factors H. J. Eysenck hexobarbitone human imipramine increase individual differences influence interaction introverts investigation iproniazid Janke Lehmann and Hopes Lienert lofepramine male measures ment meprobamate MHPG neurotic neuroticism nicotine normal observed orciprenaline oxprenolol performance pharmacokinetic Pharmacol pharmacological physiological placebo placebo group plasma levels posttreatment prediction predictors pretreatment Psychiatry psychoactive drugs Psychol psychological Psychopharmacology psychotropic drugs questionnaire reactions relationship reported response variability sample sedation threshold self-medication significant situational conditions smoking behaviour somatic specific stimulant studies subjects scoring symptoms Table therapeutic tion tranquilizer treatment Warburton Wesnes Wittenborn