Response Variability to Psychotropic DrugsW. Janke |
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Page 45
W. Janke. Inter - dose level Intra - drug class Inter - drug class Neuro - Tran- leptic / qui- Depressant Neuroleptic high high high dose dose dose dose dose dose dose dose dose dose dose dose Exp . I subjective .23 .15 .62 .26 .11 .26 ...
W. Janke. Inter - dose level Intra - drug class Inter - drug class Neuro - Tran- leptic / qui- Depressant Neuroleptic high high high dose dose dose dose dose dose dose dose dose dose dose dose Exp . I subjective .23 .15 .62 .26 .11 .26 ...
Page 55
... dose levels . The relation- ship between drug response and personality traits is essentially de- pendent on the dose level . With increasing dose levels of a barbiturate , differences between labile and stable subjects became , however ...
... dose levels . The relation- ship between drug response and personality traits is essentially de- pendent on the dose level . With increasing dose levels of a barbiturate , differences between labile and stable subjects became , however ...
Page 78
... dose ) ( 12 ) Kangas and healthy 18-38 others , 1979 volunteers nitrazepam ( 5 mg orally , ( 36 ) geriatric 66-89 ... dose and chronic ( 16 days ) ) diazepam ( 0,1 mg / kg 1.v. 10 mg orally , single dose ) pethidine ( 1,5 mg / kg u.m. ) ...
... dose ) ( 12 ) Kangas and healthy 18-38 others , 1979 volunteers nitrazepam ( 5 mg orally , ( 36 ) geriatric 66-89 ... dose and chronic ( 16 days ) ) diazepam ( 0,1 mg / kg 1.v. 10 mg orally , single dose ) pethidine ( 1,5 mg / kg u.m. ) ...
Contents
Some basic principles and their influence | 3 |
Drug Response Variability Overview of Contributing Factors | 31 |
Debus | 62 |
Copyright | |
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activity administration adrenergic drugs alcohol amitriptyline analysis antidepressant anxiety arousal behavior chlordiazepoxide chlorpromazine cigarettes smoked Claridge Clin clinical concentration correlation Debus depressant drugs depressed patients diazepam DiMascio dose drug effects drug metabolism drug postulate drug response drug tolerance effects of drugs emotional responses environmental enzyme evidence experiment experimental extraverts females genetic factors H. J. Eysenck hexobarbitone human imipramine increase individual differences influence interaction introverts investigation iproniazid Janke Lehmann and Hopes Lienert lofepramine male measures ment meprobamate MHPG neurotic neuroticism nicotine normal observed orciprenaline oxprenolol performance pharmacokinetic Pharmacol pharmacological physiological placebo placebo group plasma levels posttreatment prediction predictors pretreatment Psychiatry psychoactive drugs Psychol psychological Psychopharmacology psychotropic drugs questionnaire reactions relationship reported response variability sample sedation threshold self-medication significant situational conditions smoking behaviour somatic specific stimulant studies subjects scoring symptoms Table therapeutic tion tranquilizer treatment Warburton Wesnes Wittenborn