1196 Alk 1015 1.41 23 538 Acid 1018 5 121 132 " Grms. Solids. 1890 Apl. 25 8712100 440 Acid 1021 ་་ 904 Grms. Diet. Urine passed for the 12 bours. Reaction Specific Gravity. Phosphates 1015 92 9 1:014 34 Alk. 1016 41 13 7 1970 ..013 161 16 7 .. 712 Acid 1018 76 11 8 58 512 1019 5111 198 952 Alk. 711 Acid 1017 1.08 12 98 1:06 14 598 11114 92 11 | 8.40 a.m. 2.15 p.m. | 8.40 a.m 2.15 p.m. 8.40 a.m. 2.15 p.m. Date. Medicine 2-3 3 Sulphonal 10 4.5 27-28 1422 28-29 29-30 30-1 May 1-2 :: 1348 1388 1994 16101 68 17'8 88888 1013 1 27 178 1013 1.07 178 1011 51 15 8 1370 A lk. 1010 17 2322 1 84 26 5-6 394 Acid 1670 18901 18 2244 6-4100-8 8001] 99 2 18 2521 2 27 33 1 1010 1:15 21:3 98 8 17 2601 2 21 36 2160.2 17 31-6 2046 2 18 26 6 2582 2:55 3025742 44 30 7 2600 2:5; 1996 2:01 27.8 2062 2:50 30 5 2100 2 corded a place on the but short list of To sulphonal, therefore, may be acthat the action is of central origin. 7.20 p.m. 7.20 p.m. Quantity of urine. Phosphates. Urea. "NOCTURNAL"-6.30 P.M. TO 6.30 A.M. IN THE 24 HOURS. TABLE V. WILLIAM W., æt. 53; Advanced Second Stage of General Paralysis. less frequent, but deeper; then coinci dent with the rise in temperature and vaso-motor changes, it becomes (again recent paper ("British Medical Jour nal," 29th March, 1890), found the re tinuing the same dose, gradually subflex eventually disappears altogether. flex function of the spinal chord reside, and in some cases the patellar re May 14 1871 2100 906 Alk. 1016 1 54 17.5 98 6 98. 1012 121 13:1986) 1016 1.49 15.8 98.6 Date Medicine. C.C Grms. the 12 hours. Urine passed for Reaction. Specific gravity Phosphates. Grms. Urea Hours Sleep. 7 20 p.m IN THE 24 HOURS. CC. Grms Grms. 7.20 p.m 7.20 p.m Quantity of urine. Urea. flexes become increased, but on frequent, but of regular rhythm. Reflexes.-The skin and tendon re con reflex excitability; while Gordon in a times depresses and sometimes exalts Shick observes that sulphonal some 16-17 1010 1:36 13:8 10 " 16 20-21 " 16 21-22 1038 .. 1480 1010 88 116 11 97.8 62 1007 1-11 17.5 9 98.4 66 16 1944 2 02 26 5 22-23 Paraldehyde 60 m 956 Alk. 1009 1-22 119 10 9 98.4 2520/20 9 98.2 16 1970 1-69 NOTES TO TABLE V. Some urine lust; habits untidy; slept nearly all day, and cannot duced in frogs. There is a gradual initial hyperæsthetic stage, which is Mental and sense phenomena.-Some patients, when not sufficiently under the influence of the drug, to cause sleep, expressed themselves as nervous, shaky, and sea-sick. The pupils become dilated and sluggish. Some, on being under the influence of the drug for a week or more, complained of defective vision, and others of seeing colors. The senses of taste and smell are not affected. Noises in the ears were an invariable complaint, the majority describing it as buzzing, others ringing; a female melancholic that her head was "queer;" another that her head felt as if made of wood; while a third complained of hearing voices; but all three complained of "queer things" before. Hallucinations are, however, referred to by Bornemann, who records that his patient thought he had four arms, four hands, and two heads. This probably was a form of diplopia, which this patient is recorded as having had. The sense of hearing seems acute, out of all proportion to the other senses, more especially when the patient is asleep. The majority said they did not dream at all; others had dreams of an agreeable kind, such as dreams of home and flower gathering. A male acute melancholiac complained of disagreeable dreams when on doses of 40 grains, but would not tell their nature. A young maniac, who had been pricked with a pin when asleep and then roused up, said he was dreaming of lions and tigers. Digestion and the gastro-intestinal tract. -The appetite was never in any case impaired, but as a rule improved, and in some cases became excessive and ravenous. The case of Louisa S. may be regarded as the exception, and an example of what may occur in the case of an anæmic brain and feeble circulation, but this probably is not an unmixed anorexia due altogether to sulphonal, as she was sent here partly for refusing her food. This variety approaches what one might call anorexia already recorded by others. Sickness was rare, but was more frequent in the depressed than in the exalted. The tongue of sulphonal is probably a typical one, and, as a rule, is covered with a milky white fur, as if the organ had its first coating of white-wash; is always moist, however, and the saliva seems increased. In some cases there is diarrhoa, more frequently in females than in males, but as a rule the bowels are not at all affected. Large doses. When large and continuous doses are given the patient may sleep on almost day and night; the muscles become quite flaccid, aud locomotion impossible. If the drug be pushed further, voluntary power subsides, and when he is roused up for his food, he looks at it, but cannot stretch In the skin-sense there is a short forth his hand to take it, and when put |