Grms.

Grms.

recent paper ("British Medical Jour

nal," 29th March, 1890), found the re

tinuing the same dose, gradually subflex eventually disappears altogether. flex function of the spinal chord reside, and in some cases the patellar re

May 14 1871 2100 906 Alk. 1016 1 54

17.5 98 6 98.

1012 121 13:1986)

1016 1.49 15.8 98.6

Date

Medicine.

C.C

Grms.

the 12 hours.

Urine passed for

Reaction.

Specific gravity

Phosphates.

Grms. Urea

Hours

Sleep.

7 20 p.m

IN THE 24

HOURS.

CC.

Grms

Grms.

7.20 p.m

7.20 p.m

Quantity of urine.
Phosphates.

Urea.

flexes become increased, but on frequent, but of regular rhythm. Reflexes.-The skin and tendon re

con

reflex excitability; while Gordon in a times depresses and sometimes exalts Shick observes that sulphonal some

16-17

1010 1:36 13:8 10

"

16

20-21

"

16

21-22

1038 .. 1480

1010 88 116

11

97.8

62

1007 1-11 17.5

9

98.4

66

16

1944 2 02 26 5

22-23 Paraldehyde 60 m 956 Alk. 1009 1-22 119 10
1400 Acid 1005, 84 14.3 10
60.. 1000
1011 74 15:5 10
60, 1464 Alk 1007 80 13:3
840 Acid 1007 107 136

9

98.4

2520/20

9

98.2

16 1970 1-69

NOTES TO TABLE V.

Some urine lust; habits untidy; slept nearly all day, and cannot

duced in frogs.
increase in the
The gait is of a drunken type, going
from slight inco-ordination to stagger-
ing, reeling, and, on large and continued
doses, entire suspension of voluntary
movements. The conjunctival, skin,
tendon, and plantar reflexes, when the
patient is asleep, and for some time un-
der the influence of the drug, are fre-
quently abolished, but that of the nose
while seldom abolished, is often faint and
infrequent.

There is a gradual initial hyperæsthetic stage, which is
motor disturbances. soon lost, however, and, as will be seen
further on, gives place to a well-marked
analgesia on larger doses. It may be
observed here that sulphonal disputes
the claims of quinia to a separate ism,
for there is seen, in what one might call
sulphonalism, many of the phenomena
of cinchonism. To the maniac, with
robust circulation, or hyperæmic condi-
tions it seems to bring rest, while in
melancholia, with weak circulation or
brain anæmia, the gloom is frequently
intensified, and there may be a stupor
super-added, which often obscures the
original condition, but which fortunately
disappears on withdrawing the drug.

Mental and sense phenomena.-Some patients, when not sufficiently under the influence of the drug, to cause sleep, expressed themselves as nervous, shaky, and sea-sick. The pupils become dilated and sluggish. Some, on being under the influence of the drug for a week or more, complained of defective vision, and others of seeing colors. The senses of taste and smell are not affected. Noises in the ears were an invariable complaint, the majority describing it as buzzing, others ringing; a female melancholic that her head was "queer;" another that her head felt as if made of wood; while a third complained of hearing voices; but all three complained of "queer things" before. Hallucinations are, however, referred to by Bornemann, who records that his patient thought he had four arms, four hands, and two heads. This probably was a form of diplopia, which this patient is recorded as having had. The sense of hearing seems acute, out of all proportion to the other senses, more especially when the patient is asleep. The majority said they did not dream at all; others had dreams of an agreeable kind, such as dreams of home and flower gathering. A male acute melancholiac complained of disagreeable dreams when on doses of 40 grains, but would not tell their nature. A young maniac, who had been pricked with a pin when asleep and then roused up, said he was dreaming of lions and tigers.

Digestion and the gastro-intestinal tract. -The appetite was never in any case impaired, but as a rule improved, and in some cases became excessive and ravenous. The case of Louisa S. may be regarded as the exception, and an example of what may occur in the case of an anæmic brain and feeble circulation, but this probably is not an unmixed anorexia due altogether to sulphonal, as she was sent here partly for refusing her food. This variety approaches what one might call anorexia already recorded by others. Sickness was rare, but was more frequent in the depressed than in the exalted. The tongue of sulphonal is probably a typical one, and, as a rule, is covered with a milky white fur, as if the organ had its first coating of white-wash; is always moist, however, and the saliva seems increased. In some cases there is diarrhoa, more frequently in females than in males, but as a rule the bowels are not at all affected.

Large doses. When large and continuous doses are given the patient may sleep on almost day and night; the muscles become quite flaccid, aud locomotion impossible. If the drug be pushed further, voluntary power subsides, and when he is roused up for his food, he looks at it, but cannot stretch In the skin-sense there is a short forth his hand to take it, and when put