Lymphatic Transport of Drugs

Front Cover
CRC Press, Apr 22, 1992 - Medical - 352 pages
Lymphatic Transport of Drugs provides a thorough review of the determinants that affect the uptake and delivery of drugs and xenobiotics to the lymphatics. Factors affecting the transport and delivery of lipophilic drugs through the lymph after oral administration, lymphatic transport of polar drugs and macromolecules after gastrointestinal dosing, transport of drugs into the lymph after parenteral administration, and particulate drug delivery systems are among the topics examined in this volume. Lymphatic Transport of Drugs is primarily intended for pharmaceutical scientists who are attempting to alter the delivery of current therapeutic agents through formulation of prodrugs, as well as for researchers designing new drugs for lymph delivery.
 

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Contents

II
3
G Lymphaticovenous Anastomoses
10
Composition of Lymph
17
Role of Lymphatics in Exchange in Normal Tissue
20
Chapter 1
24
Effect of Administration Route on Lymphatic Delivery
29
Chapter 2
37
Chapter 3
63
Chapter 4
113
Lipophilic Prodrugs and the Promotion of Intestinal Lymphatic Drug
175
Chapter 6
211
Chapter 7
233
Chapter 8
255
Particulates and Lymphatic Drug Delivery
279
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