A Balanced Omega-6/omega-3 Fatty Acid Ratio, Cholesterol and Coronary Heart Disease

Front Cover
Artemis P. Simopoulos, Fabien De Meester
Karger Medical and Scientific Publishers, 2009 - Medical - 125 pages
For more than half a century, the relationship between dietary factors and coronary heart disease (CHD) has been a major focus of health research. Contrary to the established view, current data suggest that dietary cholesterol is not a primary factor of or causes heart disease with the possible exception of the genetic forms of familial hypercholesterolemias. For instance, recent clinical trials evaluating the effect of cholesterol-lowering drugs on the development of chronic heart failure, diabetes and stroke have yielded disappointing results. On the other hand, an unbalanced omega-6/omega-3 fatty acid ratio and a cholesterol intake not consistent with the amount during evolution seem to be causal factors in the development of CHD. A panel of international experts in genetics, nutrition, fatty acid, cholesterol, metabolism and coronary heart disease has contributed to this publication, summarizing and critically discussing for the first time the importance of evolutionary aspects of diet, the omega-6/omega-3 fatty acid ratio and cholesterol intake relative to health and CHD. They also propose measuring blood fatty acids in the population in order to define the risk of CHD and other chronic diseases.This book will be of interest to physicians (cardiologists, gerontologists, and pediatricians), nutritionists, dieticians, health care providers, scientists in industry and government and policy makers.
 

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Contents

Omega3 Fatty Acid Ratio Medical Implications
1
Measuring Blood Fatty Acids as a Surrogate Indicator for Coronary Heart Disease Risk in Population Studies
22
Application to the Assessment of Fatty Acid Patterns and Various Indexes in Population Studies
35
Evolution and Cholesterol
46
A Healthy Relationship
55
Blood Cholesterol as a Good Marker of Health in Japan
63
Cholesterol and Skeletal Muscle Health
71
Is It Not Time for a Full Reappraisal of the Cholesterol Theory?
80
Cholesterol Was Healthy in the End
90
The Columbus Concept Addressing Chronic Diseases
110
Author Index
122
Subject Index
123
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