Amelogenins: Multifaceted Proteins for Dental and Bone Formation and RepairMichel Goldberg This volume is the 1st in a series of Ebooks that bridges the gap between advances in science and clinical practice in odontology. Recent advances in biology, materials science and tissue engineering are increasingly viewed as being of enormous clinical potential. Stem cell research has opened up the possibility of reconstructing teeth from the association of epithelial and mesanchymal embryonic or adult cells, as an exciting alternative to metal implants. This Ebook will examine the multifunctional nature of a group of proteins known as the amelogenins. Latest studies indicate that this protein regulates the initiation and growth of hydroxyapatite crystals during the mineralization of enamel. In addition, amelogenins organize enamel rods during tooth development, and also aid in the development of cementum by directing cells that form the cementum to the root surface of the teeth. The aim of this book is to serve as a bridge between basic biology and biomaterial sciences, and to inform clinicians about the implications of recent advances within these fields for clinical practice. |
Contents
Chapter 01
| 1 |
Chapter 02
| 19 |
Chapter 03
| 25 |
Chapter 04
| 32 |
Chapter 05
| 42 |
Chapter 06
| 56 |
Chapter 07
| 64 |
Chapter 08
| 88 |
Chapter 10
| 106 |
Chapter 11
| 133 |
Chapter 12
| 143 |
Chapter 13
| 163 |
Chapter 14
| 174 |
Chapter 15
| 191 |
Chapter 16
| 208 |
Chapter 17
| 214 |
Common terms and phrases
activity alternatively spliced AMBN AMEL ameloblasts amelogenesis imperfecta amelogenin expression amelogenin gene splice amelogenin isoforms amelogenin mRNA amelogenin protein AMELX AMELX mutations amino acid Arch Oral Biol Biochem Biol Chem biomineralization bone bovine cementum chromosome clinical Connect Tissue Res crystals Dent Res dental enamel dentin differentiation EMPs ENAM enamel formation enamel matrix derivative enamel matrix proteins enamel mineral enamel organ enamel proteins enamelin encoded exon extracellular matrix Figure Fincham flap full-length function gene expression gene splice products human IDPs implantation incisor induced interactions intrinsically disordered intron isoforms KLK4 LAMPl LRAP mammalian matrix proteins membrane mesenchymal mice mineralized tissues molecular molecules Moradian-Oldak mouse amelogenin mRNA odontoblasts Oral Sci osteoblasts periodontal ligament Periodontol phenotype porcine amelogenin PPII rat incisor recombinant region regulation residues rodent role secondary structure secretory stage self-assembly sequence signaling Simmer JP specific stem cells studies Tooth Enamel tooth germ Veis vitro vivo