oleic-acid solutions and ointments are not repelled, but they only penetrate the skin after much rubbing and kneading, with simultaneous epilation. A vehicle must be used which will dissolve the sebaceous matter of the skin, and also the remedy. Ether dissolves bichloride of mercury and iodine. Iodine is soluble in turpentine and benzine. I prefer the bichloride of mercury in ether, two grains to one ounce. Iodine oxidizes quickly in turpentine and slowly in benzine, while the bichloride always remains active.

Any of these solutions holding a parasiticide in solution, when applied to the skin, will wet or adhere to the skin perfectly, will penetrate between the epidermic epithelial scales, and into the hair and sebaceous follicles, carrying the parasiticide and dissolving the fatty secretion.

Theory has led me to this line of treatment, of which practice has shown me the great benefit. To apply the bichloride solution in ether, use a small brush over the affected surface, two or three consecutive days, then wait for the slight irritation to subside, applying any bland ointment. There are many remedies which dissolve in the fat solvents-naphthaline, thymol, carbolic acid, chloral, salicylic acid-and these may be suited to individual cases or circumstances.-New York Medical Record.

POSOLOGY AND USE OF SOME NEW REMEDIES.

Osmic acid: Best administered in pill form (made up with Armenian bole). The dose is one-sixtieth of a grain, which may be repeated several times a day. Used in epilepsy and sciatica. Agaricine: Best administered in combination with Dover's powder. Dose, one-twelfth to one-sixth of a grain. Used for night sweats. Aloin: From one-third of a grain to three and a half grains in pill form. Antipyrin: Dose from seventy-five to ninety grains, divided into three portions, on of which is to be taken every hour. Bismuth salicylate: Dose from five to seven grains, in pill form. In typhoid this dose may be doubled and repeated every hour up to ten or twelve times. Canabinone: From two-thirds to one and a half grains. Best administered mixed with finely-ground roasted coffee. Sedative and hypnotic. Colocynthin: Used subcutaneously. The dose is from one-sixth to one-half of a grain. It may also be administered in pill form, by the mouth, the requisite dose being from one-third to one grain. Convallamarin: Internally, in pill form. The dose is from three-fourths to one and a quarter grain. Euonymin:

Best given in pill form, combined with extract of belladonna or hyoscyamus. The dose is from three to ten grains. Nitroglycerin is best given in alcoholic solution. The dose is from one one hundred and fiftieth to one-sixtieth of a grain, repeated several times a day. Rossbach prefers ether as a solvent. His formula for its use is as follows: Dissolve one and a half grains of nitroglycerin in sufficient ether, and add the solution to a mixture consisting of two ounces of powdered chocolate and one ounce of powdered gum-arabic. Mix very thoroughly and divide into two hundred pastilles. Each pastille will thus contain one three hundred and thirty-third of a grain of nitroglycerin. Used in angina pectoris, and as a diuretic. Picrotoxin: In aqueous solution. Dose from one-eighth to one-sixth of a grain. Used in epilepsy. Sulphate of thalline may be given dissolved in wine or water (with some corrigerant). The dose is from four to eight grains, or one grain every hour.

THERAPEUTIC PROGRESS.

A CURE FOR WARTS.-Take fifteen grains of corrosive sublimate and dissolve in one ounce of collodion. Brush the warts carefully once a day with this solution. This remedy is more efficacious and more convenient than other recommended procedures.

AN INTESTINAL ANTISEPTIC.-Bouchard uses the following:

R. Naphthalini,

Pulverized sugar, àā.........

Oil bergamot..........

Ft. pil. xxx. Sig. One every hour.

........

Ziss. gtt. iij.

IODOLE IN EAR DISEASES.-Dr. Stretter substitutes iodol for iodoform, in a large number of cases of ear disease, and finds that in acute purulent inflammatory affections iodol applications rapidly produce marked benefit, but that in chronic inflammation of the middle ear it is generally quite useless.

SANTONINE. This drug is generally considered to act as a poison upon ascarides, but Dr. Schroeder states that santonine does not kill these worms, but its presence being distasteful to them causes them to leave their resting place and wander into the large intestine from which they can then be removed by a purgative.

ANGINA PECTORIS.-Iodide of sodium is highly recommended by Hichoed in the treatment of angina pectoris. Laschkevitch speaks highly of the effects of cocaine in doses of from one-half to one-third grains three times a day.

THAPSIA PLASTER.-Dr. Crook considers this to be one of the most vigorous of counter-irritants. There are, however, two objections to its use. These are the remarkable tendency of the eruption to spread and the occasional severe and painful character of its local action.

NITRO-GLYCERINE IN TREATMENT OF FATTY HEART.-Professor Bartholow speaks very favorably of the use of nitro-glycerine persistently in the treatment of fatty heart. It takes the strain off the weakened organ and allows it to gain strength while its work is lessened.

ERGOT IN EXCESSIVE FLOW OF MILK.-Dr. Eretzky states that ergot checks excessive flow of milk, and is capable of suppressing it entirely. It is of benefit when the mammary gland becomes swollen and inflamed in consequence of weaning the child or from other cause.

BISMUTH FOR SWEATING FEET.-M. Vieusse states that excessive sweating of the feet, under whatever form it appears, can be quickly cured by carefully conducted friction with subnitrate of bismuth, and even in the few cases where this suppresses the abundant sweating only temporarily, it still removes the fetidity which often accompanies the secretion.

HYPODERMIC ADMINISTRATION OF STRYCHNIA.-Dr. Austic says the full effects of this drug are rapidly developed when administered hypodermically. He proposes a solution of the sulphate, two grains to the ounce of distilled water, of which the proper commencing dose is two minims (1-120). If the dose exceed one-sixtieth grain unpleasant toxic effects follow.

BISMUTH FOR ECZEMA IN CHILDREN.-Widerhofer treats eczema in children successfully with a five per cent. lanolin and bismuth salve. This is thickly spread upon linen, and bandaged upon the part morning and night. Lanolin forms but a small amount of fatty acids upon the skin, while vaseline and other fats readily produce fatty acids, which to the child's sensitive skin are very irritating.

CHRONIC BRONCHITIS.-In a case of chronic bronchitis, Dr. Rex, of Jefferson Medical College Hospital, prescribed the following:

M. Sig. To be taken at first every two hours, but afterward reduced to three times daily.

IMPROVED COMPOUND LIQUORICE POWDER.-Dr. Oxley wishing to correct the unpleasant griping effect of the officinal preparation, substituted anise seed for fennel and added ginger. His formula is the following:

PERMANGANATE OF POTASH AS AN EMMENAGOGUE.-Dr. Benjamin Marshall writes to the Therapeutic Gazette: In your June issue is an article on the use of the permanganate of potassa, as an emenagogue, and asking for results. My conclusions, after using it in about fifty cases, are as follows:

(1) It acts with certainty in about seventy per cent. in selected cases.

(2) It may be given at any time, but preferably one or two hours after eating, as it is not so apt to sicken the stomach. I do not think it is any more efficient when given on an empty stomach.

(3) I have used the sulphate in a number of cases with less certain effect; the results attained may, however, have been accidental.

(4) In most cases it produces an exhilaration of spirits. (5) It has a decided tonic effect.

(6) It will become an indispensable therapeutic agent.

(7) Its disagreeable effect on the stomach is best relieved by a combination of

R. Cerii oxalas........

Cocaine hydrochlorate...........
Subnitrate of bismuth..........
Pulverized ipecac.......................

Mix. Ft. cachets; one every hour.

gr. 1.

gr. t.

gr. v.

gr..

ON THE MODE OF ELIMINATION OF MERCURY FROM THE SYSTEM AND THE TIME REQUIRED FOR ITS ACCOMPLISHMENT.

BY F. N. OTIS, M. D.,

Clinical Professor of Genito-Urinary Diseases in the College of Physicians and Surgeons, New York City.

One of the most common and important objections urged against the use of mercury in the treatment of syphilis is that it is very slowly and imperfectly eliminated from an organism more or less saturated with it and that an important amount remains in the tissues for an indefinite time. This is popularly accepted as being capable of producing various troubles from its mechanical influence and ready to enter into painful or even destructive combination with any conditions, disease or dyscrasia, which may come into unfavorable relations with it at any time during the remainder of the life of the patient. It is in this way most often claimed to affect chiefly the bony structures like the late lesions of syphilis and even believed by some to be the sole cause of many of the destructive lesions which are characteristic of the sequelae of syphilis. These claims have been difficult to combat from the fact that but little information has found its way into the text-books in regard to the mode and rate of elimination of the drug. From the experiments of Mayençon and Bergeret on animals (Robin's Journal de l'anatomie, quoted by H. C. Wood"Therapeutics," etc., fourth edition, Philadelphia, 1882) it is