This is a new class of medicines (minute pills) designed for administration of remedies in small doses for frequent repetition in cases of children and adults. It is claimed by some practitioners that small doses given at short intervals exert a more salutary effect. THE ELEGANCE AND EFFICIENCY OF PARVULES, AND THE AVOIDANCE OF CUMULATIVE EFFECT DEPEND ON OUR MODE OF PREPARATION. THE DOSE of any of the Parvules will vary from one to four according to age, or the frequency of their administration. For instance, one Parvule every hour, or two every two hours, or three every three hours, and so on for adults. children, one three times a day is the minimum dose. For You are Cautioned Against Imitations and Substitutions Offered Under Other Names. PRICE, 25 Cents Per 100. Pocket Case, 10 Varieties..... $ 2.50. 5.00 10.00. 1-10 gr. ALOIN, PARV... Med. prop.-A most desirable Cathartic. The most useful application of these Parvules is in periodic irregularities— Dysmenorrhoea and Amenorrhoea. They should be given in doses of one or two every evening at and about the expected time. DOSE. 4 to 6 at once. This number of Parvules, taken at any time, will be found to exert an easy, prompt, and ample Cathartic effect, unattended with nausea, and in all respects furnishing the most desirable aperient and cathartic preparation in use. For habitual constipation, they replace when taken in single parvules the various medicated waters, avoiding the quantity required by the latter as a dose, which fills the stomach and deranges the digestive organs. CALOMEL, PARV. 1-20 gr. Med. prop.—Alterative, Purgative. DOSE. I to 2 every hour. Two Parvules of Calomel, taken every hour, until five or six doses are administered (which will comprise but half a grain), produce an activity of the liver which will be followed by bilious dejections and beneficial effects, that twenty grains of Blue Mass or ten grains of Calomel rarely cause, and sickness of the stomach does not usually follow. PODOPHYLLINI, PARV.... Med. prop.-Cathartic, Cholagogue. 1-40 gr. Two Parvules of Podophyllin, administered three times a day, will reestablish and regulate the peristaltic action and relieve habitual constipation, add tone to the liver, and invigorate the digestive functions. Special Discounts for Large Lots. WM. R. WARNER & CO. 122 Market Street, Philadelphia. 22 Liberty Street, New York. Cornell & Pheneger Bros.; Orr, Brown & Price; Kauffman, Lattimer & Co., Agents in Columbus, O. R. Jones & Son; SURGERY. CONDITIONS WHICH AGGRAVATE SYPHILIS. Fornier (Quarterly Compend. Medical Sciences) maintains that certain physical conditions in the person infected have more to do with the gravity of syphilis than the quality of the syphilitic virus. These conditions he discusses as follows: 1. Alcoholism. A powerful factor in increasing the virulence of this affection, favoring the spreading and increasing the intensity of the cutaneous lesions; producing severe symptoms, tertiary in character, early in the secondary stage; creating special types of eruption, malignant, and involving large areas of skin surface, causing more frequent outbreaks of the syphilides, depressing the system, and finally predisposing to early nervous manifestations and causing deposits in the brain and spinal marrow. 2. Age. Syphilis is always severe at the two extremes of life. In the infant the disease, whether inherited, congenital, or acquired, is very frequently fatal, in striking contrast with its benignity in the child two, five or six years of age. In the adult it is usually mild. After fifty or fifty-five years the disease begins to be severe, and in old age it is extremely virulent. 3. Scrofula and tuberculosis act on syphilis and give rise to special symptoms, and at the same time syphilis exerts an unfavorable influence on those diseases. In those cases the syphilides have a moist, suppurating and fistulous character; ocular, osseous, and articular lesions are frequently present; and the larynx, pharynx, and nose are early and deeply involved. In scrofulous subjects a particular mixed kind of inflamma tion of the glands is noticed and in patients with tuberculous tendency pulmonary lesions are very often hastened. 4. Malaria also predisposes to grave forms of syphilis as seen in those affected with malarial toxemia. 5. All agents which depress the vital economy can serve as factors of virulence in syphilis such as extreme poverty, bad hygiene, insufficient. alimentation, prolonged lactation, fatigue, mental worry, etc. THE DIAGNOSIS OF RENAL CALCULUS.—(Dr. James Tyson, of the University of Pennsylvania, in Boston Med. and Surg. Journal.) If there is a history of excruciating pain in the region of the kidneys, extending into the groin, paroxysmal in character, a pain which is so severe that words cannot describe it, you at once suspect that there is a stone in the kidney which is seeking to find its way into the bladder. I think that there is no condition which is likely to be confounded with this. Given a severe paroxysmal pain in the region of one or both kidneys, extending to the groin with retraction of the testicle in the male, I know of only one condition that can cause it. It is true that there is described in the books what is called neuralgia of the kidney, a condition in which there are symptoms described without the presence of a stone. For myself I doubt the existence of such a condition as idiopathic neuralgia of the kidney. What has been termed neuralgia of the kidney is in all probability nephritic colic, depending on the presence of gravel. For practical purposes, therefore, we may throw out of the question nephralgia, or neuralgia of the kidney. It is also true that we have here severe muscular pains which might be confounded with pain in the kidney. The majority of persons who think that they have kidney disease, have their attention directed to it by the occurrence of pain in the lumbar muscles which they attribute to the kidney, the idea being that renal disease is associated with pain over the kidney. In point of fact, real kidney disease, other than calculous disease, is rarely attended with pain in the back. The pain of lumbago or rheumatism of the lumbar muscles is different from that due to impacted calculus. Under ordinary circumstances the former pain is not so sharp. It is true we have almost all experienced, at one time or another, a sharp lumbar pain, momentary in duration, most frequently coincident with a sudden motion or twisting of the body. But this is of short duration as compared with the pain of nephritic colic. The other lumbar pains of rheumatism are not so severe, although they may be of long duration. They are greatly aggravated by any movement of the body. They are also more readily removed. There is one other rare condition which produces pain like that of nephritic colic, to which allusion should be made, and that is floating kidney. Sometimes a floating kidney is so loose that it twists upon itself, closing the ureter very much as a rubber-hose is obstructed when it is twisted upon itself. Such obstruction causes an accumulation of urine back of it, and gives rise to intense pain, which is quite like that of nephritic colic. This, therefore, should be remembered. WARTS.-The Medical Press says: "It is fairly established that the common wart, which is so unsightly and often so proliferous on the hands and face, can be easily removed by small doses of sulphate of magnesia taken internally. M. Colrat, of Lyons, has drawn attention to Several children treated with three-grain doses this extraordinary fact. of Epsom salts, morning and evening, were promptly cured. M. Aubert cites the case of a woman whose face was disfigured by these excrescences and who was cured in a month by a drachm and a half of magnesia taken daily. Another medical man reports a case of very large warts which disappeared in a fortnight from the daily administration of ten grains of the salts." The following formula, a modification of that recommended by M. Vigier for corns, is largely used by Vidal for warts: R. Acid, salicylic, ..22 M. The solution should be painted over the affected surface each day. Treatment of Hemorrhoids BY INJECTIONS of Carbolic Acid.— (Dr. Charles B. Kelsey, in N. Y. Medical Journal.) As far as I have been able to reduce this treatment to matter of rule the results are as follows: 1. Use only the purest crystallized carbolic acid, the purest glycerine, and distilled water in the preparation of the solutions. Each, when prepared, should be perfectly colorless and clear, the acid being in perfect solution. The glycerine is added to the solution of carbolic acid in water in just sufficient quantity to make a clear fluid, and the amount is not important. As soon as a solution begins to assume a yellowish tint it should be replaced by a fresh one. 2. Use only the finest and most perfect hypodermic needles and a perfectly working, and clean syringe with side-handles. After each injection when the syringe is put away, clean it thoroughly, to be ready for the next time. 3. The treatment may be applied to every variety of internal hemorrhoides, no matter what their size. It is not applicable to external hemorrhoids, either of the cutaneous or the vascular variety, both of which may be treated by better means. 4. Before making an application give an enema of hot water, and let the patient strain the tumors as much into view as possible. Then select the largest and deposit five drops of the solution as near the center of the tumor as possible, taking care not to go too deep so as to perforate the wall of the rectum and inject the surrounding cellular tissue. The needle should be entered at the most prominent part of the tumor. If the hemorrhoid does not protrude from the anus, a tenaculum may be used to draw it into view. After the injection has been made the parts should be replaced, and the patient kept under observation for a few minutes to see that there is no unusual pain. The injection will cause some immediate smarting if it is made near the verge of the anus; if made above the external sphincter, the patient may not feel the puncture or the injection for several minutes, when a sense of pressure and smarting will be appreciated. In some cases no pain will be felt for half an hour, but then there will be considerable soreness, subsiding after a few hours. If it increases, instead of disappearing, and on the following day there is considerable suffering, which may not perhaps be sufficient to keep the patient on his back, but is still enough to make him decidedly uncomfortable, it is a pretty good indication that a slough is about to form. For the reason that it is impossible to tell absolutely what the effect of an injection is to be until at least twenty-four hours have passed, it is better to make but one at a visit and to wait until the full effect of each one is seen before making another. If, on the second day, there is no pain or soreness, another tumor may be attacked, and this will often be the case. 5. The strength of the solution must be regulated by the nature of the case, and in my own practice varies from five per cent. to pure crystallized acid. In a large, vascular, prolapsing tumor, which is well defined and somewhat pedunculated, five drops of pure acid may be used with the expectation of producing a circumscribed slough which will result in a radical cure. A thirty-three per cent. solution under the same conditions, will probably produce consolidation and shrinkage without a slough, but the injections will have to be repeated several times. A small tumor which protrudes but slightly, is not pedunculated, and can be seen and felt as a mere prominence on the mucous membrane, may be cured by a single injection of a five-per-cent. solution, which will cause it to become hard, and decidedly reduce its size, while an injection of fifty per.cent solution might made considerable trouble, the remedy being too powerful for the disease. Guided by this principle, some experience will soon determine the choice of the solution. There is no arbitrary rule which can be applied to every case. As in any other surgical operation, some cases will be more satisfactory than others, and an occasional accident must be expected; but, on the whole, it seems to be the best method of treatment yet devised. |