UPJOHN'S FRIABLE PILLS.

A Condition Never Before Attained in Pill Making.

Pills made of Dry Powdered Drugs without compression, WITH NO EXCIPIENT and no mass yielding products, permanently SOLUBLE and FRIABLE. Can be readily reduced to a powder by pressure under the thumb.

No moisture present, hence our pills can be coated with an extremely thin and soluble coating and do not become sticky.

The FRIABLE condition of our pills is dependent upon the fact that they are made up of dry powdered drugs and POSITIVELY CONTAIN NO EXCIPIENT OR MOISTURE, therefore they will not dry out and become hard and worthless like old mass pills.

The fact that they CONTAIN NO MOISTURE and that none is necessary to keep them soft as in the case with mass pills, enables us to coat them with an EXTREMELY THIN, SOLUBLE COATING, WITH NO SUB-COAT, and still have them retain the same desirable condition permanently.

Although these goods have been introduced to the profession but two or three years, they have gained such a foothold as to excite the greatest antagonism from other manufacturers. We invite the profession to make critical comparative tests and ascertain for themselves which goods they would prefer to use in their own case. Perfect division of dose is guaranteed and the same degree of solubility as possessed by the drug of which the pill is made up is assured.

Since introducing this case two years ago, sixteen hundred of them have gone into the hands of physicians, many writ ing and thanking us for sending so good an equivalent for their money. We still offer this case, filled with granules, your own selection, for $2.25, postage paid. Send for Sample Vial and Granule List, to check from.

Having had frequent inquiries for a case sufficiently large to hold pills as well as granules, we now offer this elegant seal grain, clasp case, containing 8 4 dr. and 61 dr. vials, the six small vials being filled with granules selected from the Granule list-the large vials being empty.

Price, marked with physician's name, $2.75. To receive attention, orders for either case must be accompanied by the money.

THE UPJOHN PILL and GRANULE CO.,

MANUFACTURING PHARMACISTS,

KALAMAZOO,

MICHIGAN

ESTABLISHED 16 YEARS.

BEWARE OF IMITATIONS:

OLDEN'S LIQUID BEEF TONIC

ORIGINAL

AN INVALUABLE AID IN MEDICAL PRACTICE.

LABEL.

COLDEN'S LIEBIG'S LIQUID EXTRACT OF BEEF AND TONIC INVIGORATOR.
ESSENTIALLY DIFFERENT FROM ALL OTHER BEEF TONICS. UNIVERSALLY
ENDORSED BY LEADING PHYSICIANS.

This preparation, consisting of the Extract of Beef (prepared by Baron Liebig's process), the best Brandy
obtainable, soluble Citrate of Iron, Cinchona and Gentian is offered to the Medical Profession upon its own
merits. It is of inestimable value in the treatment of Debility, Convalescence from Severe Illness
Anemia, Malarial Fever, Chlorosis, Incipient Consumption, Nervons Weakness, and maladies
requiring a Tonic and Nutrient. It is quickly absorbed by the Stomach and upper portion of the Alimentary!
Canal, and therefore finds its way into the circulation quite rapidly

COLDEN'S LIQUID BEEF TONIC appeals to the judgment of intelligent Physicians in the treatment of
ALL CASES OF GENERAL DEBILITY.

By the urgent request of several eminent members of the medical profession, I have added to each wineglassful of
this preparation two grains of Soluble Citrate of Iron, and which is designated on the label, "With Iron, No. I{"
while the same preparation, Without Iron, is designated on the label as "No. 2."

In prescribing this preparation, physicians should be particular to mention COLDEN'S," viz.. "Ext. Carnis Fl. Comp. (Colden." A Sample of COLDEN'S BEEF TONIC will be sent free on application, to any physician (enclosing business card) in the United States. Sold by druggists generally.

C. N. CRITTENTON, General Agent, 115 Fulton St., New York.

GLENN'S SULPHUR SOAP.

BEWARE OF COUNTERFEITS.

Physicians know the great value of the local use of
Balphur in the Treatment of Diseases of the Skin."

Constantine's Pine-Tar Soap.

THE BEST SOAP MADE.

Has been on trial among physicians for very many years as a healing agent By far the Best Tar Soap made.

Wholesale Depot, O. N. CRITTENTON, 115 Fulton St, New York.
Samples of above Soaps SENT FREE, on application, to any Physician enclosing card.

ANTACID TABLETS, COMPRESSED.

Sir William Roberts, M. D., F. R. S., contributed to the Pharmaceutical Journal and Transactions Aug. 24th, 1889, a scholarly paper entitled "Some Practical Points in the Use of Antacid Remedies in Dyspepsia and Gravel." This article has attracted wide attention and so many inquiries regarding it have come to us that we have pleasure in advising our medical friends that we are now prepared to supply in bottles of 100 each, as desired, Compressed Antacid Tablets of the following formula:

We shall also be pleased to mail to physicians on request a reprint of Dr. Roberts' article.

PIL. SALINE CHALYBEATE TONIC.

(FLINT'S.)

We beg leave to inform the medical profession also that we have placed upon the market, in the form of sugar-coated pills, the Saline Chalybeate Tonic, recommended by Professor Austin Flint, M. D., LL. D., in the New York Medical Journal, May 18, 1889.

The formula is as follows:

Sodium Chloride, 3 grains.

Potassium Chlorate, 3-10 grain.
Potassium Sulphate, 1-10 grain,
Potassium Carbonate, 1-20 grain.
Sodium Carbonate, 3-5 grain.

Dr. Flint says of this formula:

Magnesium Carbonate, 1-20 grain.
Calcium Phosp., precip., 1-2 grain.
Calcium Carbonate, 1-20 grain.
Iron by Hydrogen., 9-20 grain.
Iron Carbonate, 1-20 grain.

Since the summer of 1887 I have given the tonic in nearly every case in private practice in which chalybeate was indicated. In many cases I have not been able to watch the effects of the remedy, and in many I kept no records. In thirty-three cases which I have noted as cases of anæmia, with loss of appetite, etc., I have more or less complete records. In twenty-two cases I noted very great improvement, in twelve cases improvement not so well marked, and in one case no improvement.

I have also records of five cases of chronic Bright's disease of the kidneys in adults in which the tonie was the only medicinal remedy employed..

These five cases of albuminuria are reported with reference only to the effects of the “saline and chalybeate tonic. In all the cases this tonic seemed to exert an influence on the quantity of albumin in the urine.

In the great majority of the cases of anæmia, etc., in which iron was strongly indicated, the tonic seemed to act much more promptly and favorably than the chalybeates usually employed. In a certain number of cases in which patients stated that "they could not take iron in any form," the tonic produced no unpleasant effects. Reprint of Dr. Flint's article furnished on request.

AN IMPROVED FORMULA OF BLAUD'S FERRUGINOUS PILLS. Learning that it was the custom of many physicians to use with satisfactory results a pill combining the Ingredients of the well-known Blaud formula with arsenious acid, we now supply the following Pil. Blaud's Ferruginous, modified:

Iron Sulph. Exsic., 2 grains.

Arsenious Acid, 1-40 grain.

Potassium Carbonate, 2 grains.

The arsenic furnishes antiperiodic virtues to the combination and in this modified form the pill is now largely used.

SUPERIOR GLYCERIN SUPPOSITORIES.

Glycerin suppositories, when first introduced by us, were furnished in paste-board boxes, each suppo sitory being wrapped in pure tin-foil to prevent the deterioration to which it was liable by reason of the hygroscopic character of glycerin.

As a result, however, of experiments conducted during the past summer we have found that these suppositories, if kept in bottles tightly corked, will keep indefinitely without any wrapper, and we are now prepared to furnish them in this form.

As the glass bottles are too heavy for mailing, such suppositories as we have occasion to send by mail, either upon order or as samples, will still be forwarded as before; the tin-foil used being unmixed with lead, and therefore perfectly harmless. The tin-foil should, of course, be removed before using.

We believe glycerin suppositories without any artificial covering, such as tin-foil or paraffin, which has also been used for this purpose, will be far more popular with physician and patient, and serve to prevent, what sometime occurs, the use of the suppository without removal of the wrapper. Send for descriptive circulars.

PARKE, DAVIS & CO.,

Detroit and New York.

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