fourth dose; transient pains, like bone-pains, in both metacarpi, and in the long bones of upper and lower extremities (c.); two emissions in a single night (c.); very wakeful and restless (c.). [The stinging itching spots on the back of the hands have now nearly disappeared, and all irritation ceased.] Dec. 20th, 8 a.m., gl. Acon. 20, spirits of wine 5 drops, water 4 oz., mix; a teaspoonful to be taken for a dose; first dose. 8.15 a.m., rheumaticlike stiffness of r. fore-finger, lasting for about ten minutes, and causing great awkwardness in bending it (c.). Dec. 21st, 2 p.m., strange sensation down the fore-part of both thighs, as if drops of cold water trickled over them, it lasted for fully five minutes (c.) : 11 p.m., momentary tingling numbness at tip of tongue (c.). Dec. 22nd, 4 a.m., sharp transient rheumatic-like pain in anterior part of l. ankle-joint (c.); 7.45 p.m., momentary drawing pain in r. fore-finger, and at the same time pain in l. ankle, as before (c.). Dec. 23rd, 8 a.m., second dose. Dec. 24th, 10 p.m., the intestines feel paralysed and unable to propel their contents; this sensation is observed more in the region of the transverse colon than in the rectum notwithstanding, the stool when discharged is not unusually hard (c.). Dec. 26th, 8 a.m., third dose: 10 p.m., several sharp momentary prickings both in the glans and prepuce (c.). Dec. 27th, 11 p.m., drawing lame pains in r. fore-finger (c.). Dec. 29th, 8 a.m., fourth dose. (No effects followed this last dose.) Jan 1st, 1864, 8 a.m., Tr. Acon. 201‰o (E.), olfaction for five minutes, fr. a vial containing 1 drachm of this potency; first olfaction. 11.30 a.m., transient but painful aching in region of l. kidney (c.); 9 p.m., rough feel, as of sand, in l. inner canthus, lasting about two minutes (c.); repeated sharp painful shootings in r. fourth toe. Jan. 2nd, 8 a.m., second olfaction. Jan 3rd, 8 a.m., no effects; third olfaction. Jan. 4th, 8 a.m., fourth olfaction: itchy nettlerash-like eruption on back of both hands, the spots being very well marked (c.); 11 p.m., almost directly after getting to bed, momentary drawing pains in l. middle finger, and in the r. heel (c.). Jan. 5th, 8 a.m., gl. Acon. ooo (E.), spirits of wine 5 drops, water 4 oz., mix; a dessert-spoonful to be taken for a dose; first dose. 1.30 p.m., several flying painful stitches in the glans, as though the poles of a galvanic battery had been applied to the part; the pains came on most unexpectedly (c.); 7.40 p.m., raw sweeping feel at the back of the throat, w. ; constant desire to hawk up, lasting for twelve hours (c.). Jan. 7th, 8 a.m., second dose. Jan. 9th, 8 a.m., no effects; third dose: 1 p.m., a feeling

of extreme nervousness: fearful and uncertain in his actions (c.). Jan. 11th, 8 a.m., fourth dose: at noon, increased tremulousness and vertigo (c.); great confusedness both of thought and action (c.); remarkable degree of sensitiveness to the least draught of cold air (c.). Jan. 13th, 8 a.m., gl. Acon., spirits of wine 5 drops, water 4 oz., mix; a table-spoonful to be taken for a dose; first dose. 9 p.m., throughout the whole afternoon and up to this hour, a sense of feverishness hung about him, attended by great powerlessness and prostration of the entire body, the extremities particularly; pulse 96 (c.); drawing pains several times in r. thumb (c.); short dry cough (c.). Jan. 14th, 8 a.m., second dose. The feverishness of yesterday continued without intermission all through the night, but abated a good deal this morning (c.); 1 p.m., flying growing-like pains all forenoon in the metacarpi and fingerjoints of both hands (c.); sense of inward fever, attended by chilliness; a desire to sit over the fire, and a disposition to nausea (c.); on going out into the open air and walking about, the feeling of feverishness abated (c.); considerable rumbling and flatulence in the bowels (c.); 9 p.m., while sitting at tea, most unexpectedly three very sharp and painful stitches in third and fourth toes of r. foot (c.); threatening coryza, one or two hot, clear drops falling fr. the nose, and attended by slight lacrymation (c.). Jan. 15th, 8 a.m., third dose: alternation of heats and chills all night, w. restless sleep (c.); 1 p.m., frequent sneezing; profuse nasal defluxion, and sense of extreme stuffing in the head (c.); appetite completely gone, unable to take solid food (c.); on going out into the open air felt m. relieved, but on getting within doors again all the symptoms of feverishness became greatly aggravated; pulse rose fr. 95 to 112 (c.); frequent flying pains all over the body; feeling very weary, languid, and unable to rise fr. the couch; obliged to discontinue all work; the system feels quite prostrated, w. a sense of inward fever (c.); skin dry and unperspiring (c.); short, frequent, distressing, and uncontrollable cough, but without any expectoration (c.); hoarseness, and partial loss of voice (c.); 11.30 p.m., after getting to bed, all the feverish symptoms became m. aggravated and almost intolerable (c.). Jan. 16th, feverishness continues, but somewhat abated (c.); violent coryza and lacrymation (c.); harsh dry cough (c.). [He did not venture to take a fourth dose, as he felt so downright ill all over.] Jan. 24th. From the 16th to the 24th the proving was discontinued, as he felt too ill to go on any longer; the system seems now to have so far recovered

its balance as to admit of the experiment being resumed. remain at present the following symptoms:

There

Slight irritation of the edges of the eyelids, which were almost raw fr. the violence of the lacrymation (c.); discharge of thick yellow mucus fr. the nose, as in old coryza (c.); trifling cough, but without expectoration (c.); gl. Acon. oo, spirits of wine 5 drops, water 4 oz., mix. Of this mixture one table-spoonful was taken, and mixed with seven table-spoonfuls of fresh water, thereby constituting the first expansion. The remaining or further expansions were made in the same way, i. e., by taking one table-spoonful of the mixture immediately preceding, and adding to it seven tablespoonfuls of water. A table-spoonful of the mixture so expanded was taken for a dose; first expansion. Jan. 25th, 8 a.m., second expansion. Jan. 26th, 8 a.m., third expansion. Jan. 27th, 8 a.m., fourth expansion; 11.30 p.m., several sharp flying stitches in third and fourth r. toes, shortly after getting to bed (c.). Jan. 28th, 8 a.m., Tr. Acon. gtt. ooo, water 4 oz., mix; expanded as before; a table-spoonful for a dose : first expansion. Jan. 29th, 8 a.m., second expansion. Jan. 30th, 8 a.m., third expansion; the eyes water extremely, more particularly in the evening, and at night; the edges of the eyelids are sore, red, and inflamed (c.). Feb. 1st, 8 a.m., fourth expansion. [No effects from the last dose.] Feb. 15th, 3 p.m., gl. Acon. zooo, dissolved in a tumbler of water, and the whole taken at a single dose. Feb. 16th, 11.30 p.m., shortly after getting to bed, several momentary lancinating pains in r. big toe, on the inside of the ball in particular; also in third and fourth r. toes, and in the metacarpal bones of l. hand (c.); extreme nervousness and agitation (c.). Feb. 18th, 8 a.m., gl. Acon. ¿ʊʊ, as before. Feb. 20th, 3 p.m., several rheumatic-like pains in l. elbow-joint (c.); constipation; clay-coloured stools (c.); paralysed, inactive feel in the intestines (c.). Feb. 21st, 8 a.m., gl. Acon. 28, as before. Feb. 23rd, a feeling all day as of impending fever, w. nausea, want of appetite, and aching growing pains throughout the whole body, extremities particularly (c.); urine thick, sedimentous, and reddish (c.); skin of l. side of scrotum studded w. minute vesicles, pouring out a humid discharge (c.); bruised pain in r. testicle, and momentary sticking pain in l. side of prepuce (c.); several sticking pains in posterior fauces (c.).—Feb. 24th, 8 a.m., gl. Acon. 2000, as before; extreme chilliness nearly all the day (c.).

(To be continued.)

Curare (the woorari poison ?) as a Remedy for Epilepsy.

At the session of the "Imperial Royal Society of Physicians," at Vienna, June 8th, 1866, Dr. Benedict commenced some positive results of the treatment of epilepsy and allied forms of disease by Curare, remarking expressly that for this time he only commenced favorable results, and, in fact, only selected out of the favorable ones those which have been observed long enough, and can be indicated as permanent cures. At the outset he observed that epilepsy, when it has become chronic, implies a definitely modified condition of the nervous system, or of certain determining parts— a peculiar form of existence-a " diathese," as the French call it, and that in an epileptic patient we have before us a convulsible and psychical diathesis. A priori, the Curare treatment seems capable of being directed only against the development and consequences of the convulsible or spasmodic diathesis; clinical experience, however, has shown that it also exercises a happy influence over the psychical also. Of the five cases adduced by Dr. B-, the first was that of a stone-cutter, aged 20, who had suffered from epileptic fits for nine years. By the patient's account, these fits frequently ran their course with convulsions; in the hospital, however, nothing was observed but loss of consciousness, lasting from a quarter to half an hour, followed by somnolence of many hours, or even mental disturbance for two days; one such fit having occurred every month from Nov. 5th, 1864. He was subjected to treatment by Curare (about 30 injections of grain) for three months. At the commencement of treatment two slight fits occurred, and during the next fifteen months, i.e., as long as he remained under observation, no more fits occurred. The two following observations relate to two boys of 12 and 16 years, of whom the first had for four years fits of " petit mal," and for the last five months seven fits of complete epilepsy of great intensity. He was placed under Curare treatment from the beginning of August, 1864, for two months, and no fits of either "petit mal” or “ haut mal" either during treatment or afterwards, for nearly two years. The second boy had, at the age of year, in consequence of a fright, and again at 6 years of age after a fall, had an eclamptic fit, and at 16 came under treat. ment, because during the last fortnight, without any known cause, on six several days he had two or three fits, regular fits of "epilepsy." The same treatment led to the same result; the fits

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stayed away thenceforward, and have not appeared now for nine months. This is the course with all cases when the disorder sets in with young individuals where there is no hereditary tendency, and has not been going on more than a year.

Even if the fits recur several times a day, yet they cease after the first injection; so that Curare is the medicine best calculated to prevent the disease from becoming chronic. Two further observations relate to two brothers of 12 and 10, who are suffering from a disease intermediate between raging mania, chorea major, and epilepsy. They had fits twice a day of one to three hours; in which partly loss of consciousness and delirium were present, but generally, with retention of consciousness, there occurred involuntary movements, springing, pirouetting, creeping, scratching on the floor, &c., between which intervened paralytic symptoms, numbness, aphonia. Besides these fits, there was general weakness, especially in the morning. In the case of the elder brother, who had been ill five weeks, three injections sufficed; in that of the younger, whose fits came on only ten days, three injections within from three to five days served to dispel the symptoms of psychical and motorial excitement. As toxical symptoms, Dr. B- once saw paralysis of the rectus internus, which rapidly passed off, and a shivering chill, which not only denotes a toxical symptom, but also one which is vicariously substituted for the fit: he also witnessed constrictions all of which, perhaps, so much the more clearly indicate interparoxysmal symptoms, as they appeared in a case where they existed already before treatment, and disappeared under continued Curare treatment. The injections were thrown in three times a week, under the skin on the neck, and, according to the effect, continued from six to eight weeks or more. Dr. B― uses solutions of the officinal preparation in the proportion of 1 to 60, and injects grain at a time.

Copaiva and Cubebs as a remedy for severe cases of Croup

and Croupose Angina.

Some time ago, Dr. Trideau, a physician of Andouille, communicated to the Parisian Gazette des Hôp. (No. 21 of last year) a detailed report of three cases in which violent croup and croupose angina were most successfully treated with Copaiva and Cubebs.