190. Near the wrist, on the flexor side of both forearms, there occurred closely-set pimples the size of a hempseed, that itched severely. Szg., w. t. dil. On the 1. little and ring finger he felt a numbness, extending from the second joint to the ends of the fingers, such as one feels when a limb has been a long time stretched, it lasted only about 4 minutes, and went off on rubbing with the other hand. Ab., w. t. M. T. Numb feeling in the joint of the 1. humerus to the finger joints, worst on the volar aspect of the hand, the thumb, and the little finger, lasting about 6 min., recurring after about 20 min., but weaker, and lasting only 4 min. Ab., 4 hs. aft. tkg. M. T. LOWER EXTREMITIES.-On the outside of the r. thigh he felt a drawing. Dsch., 10 min. aft. tkg. dil. A cutting pain, lasting about 10 min., in the flexor musles of both thighs, extending into the hock. Ab., w. t. M. T. There occurred a sudden, lightning-like, tearing pain on the outside of the r. knee-joint, which extended from the most external surface of the leg to the ankle, but went off again as rapidly as it appeared. Ab., M. T. Heaviness and weariness in the legs; his gait, which was generally rapid and easy, became trailing, so that when he got home he was as tired as if he had taken a long walk. Ab., M. T. From the anterior surface of the r. thigh to the knee, a shudder, that lasted but a few seconds, which after 4 h. recurred in the nape, and spread over the back to the sacrum, but only lasted a few moments. Great weariness in the legs. Weariness in the knees and Szg., im. aft. tkg. M. T. Ab., 13 hs. aft. tkg. M. T. Szg., im. aft. tkg. M. T. prostration of the whole body. 200. In the lower extremities, besides the weary feeling in the muscles of the calves, a slight, constant, but troublesome twitching. Schr., M. T. Soon after breakfast, on rising from his seat, weariness and heaviness in the legs, that lasted 12 hs. Ab., 2nd day aft. tkg. M. T. In the whole of the 1. lower extremity, a long-continued numb-feeling, produced by sitting for a very short time. After this there occurred in the 1. knee-joint a weak sensation. Dsch., 2 hs. aft. tkg. dil. In the evening, after going to sleep, a sudden jerk through the whole body, which woke him out of sleep. Szg., im. aft. tkg. M. T. In the evening there occurred, in the middle of the extensor side of the 1. thigh, 2 pimples the size of peas, that itched much, and which only went off after a few days. Szg., 3rd day aft. tkg. M. T. PULSE. The pulse was somewhat altered. Er., 11⁄2 h. aft. tkg. M. T. Acceleration of the large soft pulse by 14 beats. Szg.,im. aft. M. T. In the evening, acceleration of the pulse by 10 beats, at the same time roaring in the ears, heat and perspiration for 10 min. Szg. M. T. SKIN. The general integument was hot, dry, and turgid. Jen. S., 1 dil. Increased temperature of the skin. Jen. S., 1 dil. 210. The colour of the skin of the face became yellowish. Stn. PERSPIRATION.-Profuse sweat. Er.,h. aft. tkg. 1 dil. Copious sweat an hour after falling asleep. Szg., 1 dil. About midnight, copious sweat. Szg., 1 dil. SLEEP.-Sleepiness. Szg., soon aft. tkg. M. T.; Er., 20 min. aft. tkg. 1 dil. Unusual sleepiness. Jen., some hs. aft. tkg. 1 dil. After a meal, great sleepiness. Schr., w. t. M. T. Scarcely had he lain down (at noon) than he was seized with such sleepiness, that he could not resist giving in to it, whereupon he immediately fell asleep. Ab., s. hs. aft. tkg. M. T. When sitting quietly at his desk, he was seized with sleepiness, so that he lay down on his bed, and after a sleep of 20 min. awoke quite refreshed. Er., 1 h. aft. tkg. M. T. He was so overpowered with sleepiness that he could scarcely open his eyes. Er., in the evening, 35 min. aft. tkg. M.T. 220. Every movement he performed with a view to keep off sleep, became by degrees slower, until it came to such a point that he could not reach a glass of water that stood near him, though he made an effort to do so. Er., w. t. M. T. He gradually fell asleep, and after about 2 hs. was awakened by some one crying for help in the street. After that he could not again go to sleep. Er., w. t. M. T. Though his eyes were heavy he could not sleep. Stn., w. t. M. T. Though he usually slept quietly and without waking, this night he was very restless, and constantly turned hither and thither. His sleep, which was frequently broken, was only a half sleep. Every noise in the neighbouring bustling street he was aware of, he heard even the ringing of the door bell and the striking of the clocks, which was very tiresome for him. Dreams of the most various sorts troubled him all night. Accustomed to early rising, he could not get up this morning before 6 o'clock, when he felt more tired than he did the previous evening on going to bed. The head was at the same time heavy and confused. A glass of water gradually woke him up completely. Stn., im. aft. tkg. 1 dil. Dreams of small humming-birds, which continue after waking and falling asleep again. Ab., w. t. M. T. SENSATIONS.-Slight tired feeling in the lower extremities. Schr., 6 hs. aft. tkg. M. T. Fatigue in the arms and legs. Szg., soon aft. tkg. M. T. Feeling of fatigue in the knees, thumb, elbows, and masticating muscles. Szg., soon aft. tkg. 1 dil. dil. Fatigue in the legs and forearms. Szg., soon after tkg. 1 Feeling of fatigue in the arms. Er., soon aft. tkg. 1 dil. 230. Unsteady gait, and soon tired. Er., soon aft. tkg. 1 dil. Fatigue of the whole body. Er., 14 hs. aft. tkg. M. T. B Prostration and fatigue were his constant companions all day long. Er., M. T. His usual occupation tired him soon, and caused him to breathe deeply often. Br., w. t. dil. He was seized with a feeling of fear, restlessness, heaviness in the limbs, general fatigue and confusion of head; a feeling of warmth streaming out from the stomach, and extending all over the body. Er.,h. aft. tkg. 1 dil. Feeling of stupefaction lasting an hour. Er., h. aft. 14 tkg. 1 dil. Somewhat increased heat over the whole body with slight sweat, and rare yawning. Er., 14 h. aft. tkg. 1 dil. dil. Feeling of heat in the right half of the body. Br., w. t. Feeling of slight intoxication, which, however, does not prevent him thinking or working, for which he possesses more than usual aptitude. Szg., w. t. dil. While taking the M. T. and 1 dil. he noticed that he could not bear smoking cigars so well as usual. Szg. 240. Dislike to tobacco smoke. Loss of weight. Stn. Tco. DR. ROTH ON FERMENTS.* DR. ROTH reminds his readers of previous "studies," in which he exposed the futility of what he designates as the "materialistic tendency "-the idea of treating the living body as a mere retort for instituting chemical experiments to neutralize disease; and speaks of the Iatrochemists of Liebig's school (who referred all such agents as drugs, poisons, contagions, and miasmata, to a fermenting process), as victims of a fleeting fit of fashionable folly. He gives Pasteur a large share of credit, for having scared away such dreams, and proposes to give a brief sketch of that remarkable *Abstract of Dr. Roth's Studien der Arzneimittllehre No. 17, in Clotar Müller's Homöopathische Vierteljahrschrift. Jahrgang 15, Heft. 1, page 92. man's discoveries, in chronological order, from 1858, with further researches by Davaine and Claude Bernard. By way of preface, he remarks that PROTOZOA are destined to play an important part in medicine, naming several species under the three "families " Vibrio, Monas, and Paramecium. These minute creatures have been observed in incalculable numbers in the stool and urine of patients by various medical men on the Continent and in England, as Pouchet, of Rouen; Stevens, Raincy, Hassal, Thomas Richardson, John Brandon, and Patrick Reilly, in England; Davaine, Rayer, Lambl, Gluge, Valentin, Donné; and in Sweden, Malmsten and Seeman. The "Vibrio proper" was so abundant in the characteristic rice-water evacuatious of cholera patients, that the disease was by some ascribed to their presence; a theory which Dr. Roth utterly rejects, on the ground that they are so widely distributed in nature, make their appearance in all infusions, whether animal or vegetable, and at every season of the year; though he does not deny that they may aggravate the disease by their invariable abundance in such stools. They occur in other forms of diarrhoea, and were probably so discovered by Loewenhoeck early in the last century, before the genera of such animalcules had been defined. He observed that they disappeared as soon as his stools acquired consistency. The result of recent observations seems to point out— 1. That they are not seen in matter thrown up from the stomach. 2. That they are developed in the lower bowels only during life; disappearing entirely not only as soon as decomposition commences, but when animal heat has ceased. One case only is recorded where the Vibrio was found in cholera patients twelve hours after death by Dr. Hassall (who also found a very much smaller number in the stools of healthy persons). In a case of phthisis, Devaine found, and showed to several of his colleagues, the vibrio in the stool for weeks together. Rayer, in a case of chronic inflammation of the bladder, |