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For sample and literature, address Reed & Camrick, New York, N. Y.

AN EARNEST WARNING.

A Little Valley (Montana) rancher put up the following notice on the fence which incloses his grain field: "If any man's or woman's cow or horse breaks through this fence and destroys this grain, his or her tail shall be cut off, as the case may be. I'm a Christian man, but d-n any one that lets their critters run loose o' nights."

For elegant granules address Detroit Granule Co., Detroit, Mich.

For fine surgical instruments address William V. Willis & Co., 134 South Eleventh street, Philadelphia.

For samples of Syrupus Roborans and Peptic Essence, address Arthur Peter & Co., Louisville, Ky. Express charges at your expense.

For the Herald Buggy Case send to Willis H. Davis, Keokuk, Iowa.

"How did all the people in this town happen to be afflicted with St. Vitus' dance?"

"They're not. That's the bicycle dodge."

For liberal sample of Melachol, send to Alta Pharmacal Co., St. Louis, Mo. You pay express charges.

What better nerve tonic can you have than Celerina? Full bottle free if you pay express charges. Rio Chemical Co., St. Louis, Mo.

Free samples of Uterine Wafers by addressing Micajah & Co., Warren, Pa.

For literature in regard to dry batteries address Chloride of Silver Dry Cell Battery Co., Baltimore, Md. Mention this journal.

For one dollar you will receive a large package containing four valuable bottles-Elixirs of Six Iodides, Six Bromides, Six Aperieus and Six Hypophosphites. Walker-Green Pharmacal Co., Kansas City, Mo.

Perrysburgh, O., February 23, 1893. The results obtained from Freligh's Tablets in my trials were favorable, as was the use of Freligh's Tonic. Have not tried the remedy for Rheumatism. Should like to do so.

Class of 1852. H. A. Hamilton, M. D. A PHARMACEUTICAL TRIUMPH.-There is probably no laxative or cathartic in the materia medica, which is more widely known and more generously used, especially as a home remedy, than Castor Oil. Its only objection has been its taste. Now, however, even this has been removed and we have "A Pleasant Castor Oil." Laxol is pure Castor Oil, sweetened with Benzoic Sulphinide and flavored with Oil of Peppermint. By referring to our advertising pages, the readers of this journal will earn how they can procure samples and literature without expense. Laxol is used throughout many of the best hospitals in the East, where it has been known for some time.

CONVENIENT. (Antiseptic)-As a very prominent surgeon recently stated, "Sennine" is not only the most convenient for a surgeon, but the general practitioner as well, of any product that I have any knowledge of.

Since their introduction the Hypophosphites have firmly maintained their hold on profesional and popular confidence and to-day are prescribed alone and in combination by more physicians than any other remedy. This is strong testimony to their superior worth, because of their fine tonic and constructive properties, which have been and will continue to be a means of relief and strength to thousands. McArthur's Syrup Hypophosphites (Lime and Soda) Comp. is a reliable preparation worthy of trial. If a stimulant is needed you may add it. It isn't there when you do not need it, as McArthur's Syrup is simply a tissue builder, a permanent. tonic.

"So young Smithers has been getting married?" "I hadn't heard of it. Whom did he marry?" "I happened to overhear Dr. Bradley of Yonkers telling my neighbor about it. He said that young Smithers had got Ann Giny Pectoris. I reckon it's that young girl that boarded at his ma's house last winter."

At a recent meeting of the trustees of Jefferson Medical College, Philadelphia, the honorary degree of LL. D. was conferred on Dr. John Collins Warren, Professor of Surgery in Harvard University.

Washington, D. C., November 21, 1894. Jerome Kidder Mfg. Co., 820 Broadway, New York-Dear Sirs: * * The more I use other coils the more superior I find the Kidder. The cabinet I bought three years ago has given entire satisfaction. * * J. H. Moore, M. D.

728 Seventeenth street.

A chiropodist announces on his cards that he has had the honor of removing corns from several of the crowned heads of Europe.-Printer's Ink.

INGLUVIN.-I have found this new remedy to be all that has been said for it. It is almost a specific for the sickness of females during the period of gestation. I use it in place of Pepsin, in 5 and 10-grain doses. I have found Pepsin variable and frequently inert.

Geo. F. Meeser, M. D.

Thirteenth and Dickinson streets, Phila. "All the symptoms, doctor, you say, of hay fever?" exclaimed the curate, who was traveling to the Antipodes for his health; "but how can one get hay fever in mid-ocean?" "I don't know," replied the doctor. "But we have several grass widows on board, and you have been a great deal in their society."

Shrub Oak, N. Y., September 2, 1895. The Abbott Alkaloidal Co., Station X, Chicago -Dear Dr. Abbott: When I look back upon more than forty years of practice in the old rut and think of the useless luggage I have borne about a rough country and dispensed to a suffering clientage, and now find unspeakably better results from the exhibition of your neverdisappointing alkaloidal preparations, I can hardly realize the delights of the new era. I am not only determined, but thankful to change the old for the new, and continue with delight the practice of medicine which I was just about giving up. I want the Clinic and all the rest of the alkaloidal literature. It makes me a boy again. I am, very truly yours,

JAMES HART CURRY, M. D. Send for price list, literature and free sample copy of The Alkaloidal Clinic.

Zing Sub-Gallate is an odorless succedaneum for Iodoform. See page opposite contents. HAEMOFERRUM.-Dr. C. W. Chittick (Pathologist to Harper Hospital, Clinical Professor of Medicine, Detroit College of Medicine), Detroit, Mich., states: "I am at present using Haemoferrum (Stearns') in St. Mary's Hospital, and with very good results. I find the pilloids the best possible form of iron in which to administer such preparations. Haemoferrum has thus far proven to be equal in value, regarding assimilation, to any other form I have ever tried. I'. is borne by the most delicate stomachs. In two cases of Anemia in private practice the results were entirely satisfactory."

J. E. O'Connor, M. D., B. Ch., Leicester, England, says: "In a case of urethritis, accompanied by cervical cystitis and urethral synovitis, the administration of Sanmetto was attended with most satisfactory results. The drug appears to relieve the pain, reduce the irritation and produce healing and cessation of the muco-purulent discharges more speedily and efficaciously than any other remedy yet offered to the profession. In the case alluded to a marked improvement in the condition of the affected portion of the urinary tract was speedily followed by disappearance of the arthritic trouble. The patient had previously been treated with santal oil, salicylate of soda and acetate of potash."

Rules for Foretelling the Weather.

THROUGHOUT ALL THE LUNATIONS OF EACH YEAR, FOREVER.

This table and the accompanying remarks are the result of many years' actual observation, the whole being constructed on a due consideration of the attraction of the Sun and Moon in their several positions respecting the Earth, and will, by simple inspection, show the observer what kind of weather will most probably follow the entrance of the Moon into any of its quarters, and so near to fact as to be seldom if ever, found to fail.

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OBSERVATIONS.-1. The nearer the time of the Moon's change, first quarter, full, and last quarter, are to midnight, the fairer will be the weather during the next seven days.

2. The space for this calculation occupies from ten at night till two next morning.

3. The nearer to midday or noon the phases of the Moon happen, the more foul or wet weather may be expected during the next seven days.

4. The space for this calculation occupies from ten in the forenoon to two in the afternoon. These observations refer principally to the Summer, though they affect Spring and Autumn nearly in the same ratio. 5. The Moon's change, first quarter, full, and last quarter, happening during six of the afternoon hours -i. e., from four to ten-may be followed by fair weather; but this is mostly dependent on the wind, as is noted in the table.

6. Though the weather, from a variety of irregular causes, is more uncertain in the latter part of Autumn, the whole of Winter, and the beginning of Spring, yet in the main the above observations will apply to those periods also.

7. To prognosticate correctly, especially in those cases where the wind is concerned, the observer should be within sight of a good vane, where the four cardinal points of the compass are correctly placed.—Bull. Nat. Med. Exchange.

Doctor, are you really interested in the subject of Rectal Medication without surgical procedures? Then send to Charles L. Mitchell, M. D., 1016 Cherry street, Philadelphia, for a pamphlet giving full particulars, formulas, etc., of a practical and convenient method of treatment. Free to World readers.

You are now looking around for a good place to buy your winter suit. E. O. Thompson, Importer and fashionable Tailor, 1338 Chestnut street, Philadelphia, makes a specialty of professional clothing. The most wonderful thing is, also, that his prices are very reasonable. Send for samples and prices, free, if you mention this journal.

RUSSIA'S ABOLITION OF PRIVATE SA

LOONS.

By far the most important evidence of this trend of European public opinion is to be found in the action that Russia has now taken. In all the history of the modern temperance movement, no public law or decree has ever attempted any task so gigantic or of such farreaching importance as that which Russia's new law has undertaken. For Russia has determined upon nothing less than a complete government monopoly of the manufacture and sale of the liquor supply of the entire empire. Somewhat more than two years are to be allowed for the system to attain completeness. It is to be put (Continued on page xx.)

The knowledge that a man can use is the only real knowledge; the only knowledge
that has life and growth in it and converts itself into practical power. The rest
hangs like dust about the brain, or dries like raindrops off the stones.-FROUDE.

The Medical World. ufacturers of pharmaceutical preparations

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The Cultivation of Medicinal Plants. In our last April number appeared an editorial article on the subject "Relieving a Crowded Profession." A paragraph in that article related to the advisability of physicians raising and gathering medicinal plants as a suitable occupation for leisure time. From the number of inquiries we have received asking for practical directions regarding the subject we judge that it attracted considerable attention. While this was a suggestion which we thought that each physician could best put into practical shape for himself, according to the peculiar climate, soil and other conditions of his own locality, yet we at once began making careful investigations among the pharmaceutical colleges and the large purchasers and man

for detailed information to place before our readers. To our surprise, the idea generally met with discouragement. From ameng the replies, both verbal and written, we take the liberty of quoting the following able letter received from the well-known firm: of Parke, Davis & Co., Detroit, Mich.

J. J. Taylor, M. D., Editor Medical World, 1520 Chestnut Street, Philadelphia, Pa.

Dear Doctor:-We hereby acknowledge receipt of your esteemed communication with reference to the cultivation of medicinal plants by country physicians, both as means of pleasure and profit. In this connection we have also carefully read your editorial in The Medical World and should very much like to give you substantial encouragement in the good work you have undertaken by pointing out or explaining the modus operandi whereby this occupation could be made of benefit to the country practitioner. We fear that we shall be unable to do so, however, because of the fact that this, like all other enterprises which are open to free competition, is already overdone. We here refer particularly to the collection of medicinal plants, etc., Mother Nature having so plentifully supplied us with these that their cultivation must, for the time being, be left out of consideration. It is probable that not more than one-tenth of one per cent. of the natural annual production is consumed. Of course, this estimate does not hold good in all cases, as there are some, the natural supply of which must, in the not-far-distant future, be considerably decreased, when their cultivation may prove lucrative, if properly handled.

The gathering of crude botanical drugs is most largely conducted throughout the States of West Virginia, North and South Carolina, Kentucky and Tennessee, and particularly along the foot hills of the Blue Ridge Mountains, where, for many years, it has become a sort of local industry. This may be accounted for,. perhaps, by the fact that in this section there grow a greater variety than in any other part of the country. The people in this section have, by long experience, become thoroughly acquainted with the different species and have really become good botanists in so far as such knowledge is required for the purpose of collecting herbs, although they have, perhaps, never seen the inside of a text book upon this subject. You will understand by this that book learning is not an essential feature to success in this business, and that any time spent in the occupation by a physician would very likely return a poor compensation for his service, because of the

fact that he would have to compete in the open market against similar products offered by people who have spent neither time nor money in preparing themselves for the occupation which they follow, and are consequently enabled to dispose of their goods much cheaper than a physician could possibly afford to do and at the same time obtain a fair and reasonable reward for their labors.

It is with much regret that we so plainly state the conditions surrounding this business, as it must, of course, be entirely contrary to your cherished hopes and expectations that the cultivation of medicinal plants might prove an opportunity for the relief of the overcrowded medical profession. We have thought best, however, to be plain and candid in our treatment of this matter, that none may be persuaded, through our influence, to embark in an enterprise when surrounded by natural conditions which are antagonistic to its successful consummation.

For cur own supplies of crude drugs we have special arrangements whereby we at all times have at hand ample quantities of the most recent collection, and at no time is it necessary for us to go upon the market for these goods. This arrangement is, of course, maintained at considerable expense, and the education of collectors to our needs has required much careful attention aside from the usual supervision incident to the business, but it is the only reliable method upon which a conscientious and enterprising manufacturer can depend for his supplies of this character of crude material.

Regarding the three questions which you propound with reference to this matter will say in reply to the first that we consider the United States and National Dispensatories the best books for reference in guiding one in the collection of medicinal plants. These books are, of course, quite expensive, but we do not know of any others which would answer the purpose nearly so well.

As to your second and third questions, we shall have to acknowledge our inability to afford any reliable information, as, owing to the abundance of the natural growth of medicinal plants, both native and foreign, there has developed no need of their cultivation, and foreign medicinal plants are placed in the hands of the manufacturer so cheaply as to exclude all possibility of their profitable production in this country.

Trusting that our communication may prove of some value, and soliciting your further inquiries whenever our opinion may prove serviceable, beg to remain, very truly yours, PARKE DAVIS & CO.

B.

We wrote the paragraph in question, having in mind, as one example, the history of quinine. By reason of the scarcity of the wild cinchona trees this article was quite expensive until, about thirty-five years ago, the cultivation of the tree was begun in the East Indies, and later in Jamaica and Mexico. Since the cultivated trees have been large enough to make supply from them available, the price has declined, a plentiful

supply being at all times assured. We had in mind, also, the recent rise in the price of certain plant derivations far beyond their usual market price. For example, pilocarpine rose from 6 cents per grain, in 1892, to 38 cents per grain at the present time. We believe that it has not yet been demonstrated that the tree pilocarput pennatifolius, could not find some habitat within this large country where the conditions would be favorable to its cultivation. Other examples may occur to each reader, according to his observation and experience. We now leave this interesting question open for whatever information our readers can supply in regard to their respective localities.

We wish to call especial attention to the leading article in this issue, on A New Therapeutic Agent for Acne Pustulosa, by Samuel G. Dixon, M. D., Professor of Histology and Microscopical Technology in the Philadelphia Academy of the Natural Sciences, Executive Curator of the Museum of the Academy, member of the College of Physicians of Philadelphia and of the American Philosophical Society.

Dr. Dixon is one of the leading original investigators in America in the line of synthetic and physiological chemistry and bacteriology. He anticipated by nearly one year the discovery of the possible immunizing effects of a derivative or product of the tubercle bacillus. His discovery was published in the Medical News of October 19, 1889. Koch's first announcement was made in August, 1890, to the Berlin session of the World's Medical Congress.

Dr. Dixon's monograph, published October 19, 1889, announces two hypotheses, as follows:

"First. It is possible that, by a thorough filtering out of bacilli from tubercular material, a filtrate might be obtained and attenuated so that by systematic inoculations a change might be produced in living animal tissues that would enable them to resist virulent tubercle bacilli." (This was the identical one upon which Koch based his investigation).

"Second. To bring about a chemical or

physical change in living tissues that would resist tubercular phthisis, it is possible that inoculations with the bacillus would have to be made; yet, before this could be done, the power of the virulent bacilli would have to be diminished, otherwise the result would be most disastrous."

Thus we see that an American's discovery has been credited to a German scientist. In the permanent history of science, however, this error will be corrected.

Professor Dixon's article in the present issue of The World is one of direct therapeutic value. It suggests, also, promising. treatment for other diseases characterized by some elements of the one under consideration. The use of the amide groupurea, creatinin, taurin, etc., is new excepting in purely experimental practice. We hope that they will prove entirely practical in general clinical practice, and will prove to be of great use to the profession in the treatment of hitherto intractable conditions.

In "Nature," Thursday, November 20, 1890, Dr. T. Lauder Brunton says:-"One's first thought would naturally be that the substances formed by the tubercle bacillus itself would be chosen by Koch for curative as they have by Dixon for protective purposes. Professor S. Dixon, Philadelphia, has succeeded in rendering animals resistant to inoculation with tubercle by previously inocculating them with the products of growths of the tubercle bacillus.'

AN IMPORTANT DEVELOPMENT OF LOCAL ANESTHESIA.

At the Philadelphia County Medical Society, Nov. 13th, Prof. Theophilus Parvin demonstrated the new advancement in the methods of producing deep and extensive local anesthesia developed by Prof. Schleich, of Germany. The method consists in the injection deep into the tissues of a solution consisting of part morphine, 1 part cocaine, 2 parts common salt and 1000 parts pure water. Prof. Schleich performs capital operations-amputations, removal of tumors, etc., under this local anesthesia. Prof. Parvin allowed his arm to be deeply cut and sewed up as a demonstration before the Society. Particulars next month.

Many thousand subscriptions expire with this issue. Have we not notably improved THE WORLD in the past year? The sending of subscription price is a business matter that we wish could be avoided, but, vou know,we cannot live and pay for paper, etc on social relations alone The price is low enough. isn't it? Kindly s'nd renewal at once and then we will have a good social time all the year, and forget that any money consideration is necessary. Or better, send $3 for four years, and avoid the necessity of sending every year, and save 1 in the bargain.

Original Communications.

Short articles on the treatment of diseases, and experiencewith new remedies, are solicited from the profession for this department; also difficult cases for diagnosis and

treatment.

Articles accepted must be contributed to this journal only. The editors are not responsible for views expressed by contributors.

Copy must be received on or before the twelfth of the month for publication in the next month. Unused manuscript cannot be returned.

Certainly it is excellent discipline for an author to feel that he must say all he has to say in the fewest possible words, or his reader is sure to skip them; and in the plainest possible words, or his reader will certainly misunderstand them. Generally, also, a downright fact may be told in a plain way, and we want dowright facts at present more than anything else.-RUSKIN.

READ. REFLECT. COMPARE. RECORD.

A New Therapeutic Agent for Acne Pustulosa.

Editor Medical World:-Early in April last I was requested by an acquaintance to examine a relative of his with a view of determining whether there could be any possibility of curing or relieving an inveterate case of acne that had proved invulnerable to all the ordinary methods of treatment. Rather for the sake of obliging than with any hope of being able to successfully advise him, I consented.

Without exaggeration, it was positively the most aggravated case of the disease, acne pustulosa, not only within my own experience, but in that of all my professional friends who have seen the case with me. The entire face and neck were involved. Dozens of pustules were discharging their contents, and though it was not yet noon, the second clean collar that he had put on that morning was practically saturated with blood and pus. It was quite easy to understand the patient's declaration that he was being incapacitated in his daily pursuits by reason of the disgust that he engendered among his associates.

The history of the case is as follows: D. F. B., born Jan. 10, 1877; white; weight 106 pounds, height 5 feet 2 inches; anemic and subject to habitual constipation; family history good; no similar case among his connections. The present trouble is of six years' duration; he has consulted many physicians and specialists, besides using proprietary and other unofficinal and unauthorized remedies, but without improvement. Attention to diet, etc., according to his physicians' directions, has apparently had no effect. His general appearance shows that he is naturally neat and careful of his person, but he assures me that it is a

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