realize the advantage which freshness of material and early manipulation would give them over other pepsin manufacturers who buy material in Chicago and transport it by freight to their laboratories.

By the aid of expert chemical talent, Armour & Company utilize their vast supply of raw material almost as soon as removed from the animal, the result being a line of digestive ferments unequalled by any in the market. "The Pork Packer in Pepsin making" marks a step in the march of progress, and is an indication of great import in the field of physiological chemistry.

A FREE sample of Colden's Liquid Beef Tonic will be sent you if you will address C. N. Crittenton, IIS Fulton St., N. Y., mentioning this journai.

As a prophylactic and disinfectant, Listerine is at the head of its class.

ANTIPYRINE, Lanoline and Saccharine are imported by Schulze-Berge, Koechl & Movius, New York.

FOR hemorrhoids use Fred. W. Stewart's ointment, Oswego, N. Y.

THE Peacock Chemical Co., St. Louis, Mo., have three superb preparations in Bromides, Fucus Marina and Chionia.

E. O. THOMPSON, Importer, Tailor and Clothier, 1338 Chestnut St., Philadelphia, will fit you out with that new autumn suit. Be the earliest out in your

town.

BILL. "Hey. Jim, I'm almost broke."

Jim.-"So'm I. What shall we do to increase our capital ?"

Bill. "I've an idea. You buy a dozen bottles, and I'll buy a dozen corks, and we'll invent a remedy that will cure all the ills that flesh is heir to."

Jim. "Have you a recipe?"

Bill "No. We'll invent that, too."

HAYDEN'S Viburnum Compound is a reliable old stand-by in female troubles.

FRELIGH'S Tablets for consumption, &c., are having a steady, regular sale. Address I. O. Woodruff & Co., 88 Maiden Lane, New York, N. Y.

FOR standard pharmaceutical specialties, address Wm. R. Warner & Co., 1228 Market St., Philadelphia, Pa.

SEE the new and unique advertisement of the Coulter Vaporizer and Atomizer Co., Toronto, Ontario, Can.

SEND for the valuable and instructive pamphlet, "Posture the Handmaid of Medicine," to the Daggett Table Co., Buffalo, N. Y. Mention this journal.

Specialists

THE Hastings Truss contains no glass. in trusses, supporters, belts, &c. Hastings Truss Co., 224 South 9th St., Phila.

SEND for Febriline, the tasteless quinine, made by he Paris Medicine Co., 212 N. Main St., St. Louis, Mo.

A NEW CURE.-Mrs. Cribber-What has become of all your Cleopatra jewelry-the asps, snakes, serpents, and things?

Mrs. Bibber-Hush! Don't let my husband hear you. I have hidden them away. "Haven't you worn them at all?"

"I wore them once, and the momeni my husband saw them he rushed off to a doctor. The next morning e took the pledge. I shan't wear them again unless he backslides."-Med. Review.

BOVININE is winning laurels for itself all over the country.

NESTLES Milk Food is a good supporter in Cholera Infantum.

PHENACETINE IN INFLUENZA.-This medicament, which in Italy is used as an analgesic-antithermic in the treatment of influenza, has been successfully employed by me in the Military Hospital at Lille.

Its action is prompt, and it does not, like quinine and the salicylate of sodium, give rise to surexcitation or ringing in the ears. Phenacetine increases the urinary secretion, and hence it does not determine, by accumulation, the appearance of toxid phenomena. It has no unfavorable action upon the kidneys.

The dose of Phenacetine varies from one to one and a half grammes daily, given in three to four doses at equal intervals. The amelioration in the patient is apparent after the first dose. The temperature falls and the pains cease promptly. The feeling of fatigue disappears more slowly. There is an augmentation of the urine, and this, with transpiration, marks the breaking up of the malady. In 24 or 48 hours alter the beginning of treatment by Paenacetine all symptoms disappear, and the patient enters into convalescence.Bulletin Med., du nerd., Bull. therap., June 8, 1892. -By E. Baude, M. D.

FOR the advantages of cut rates in surgical instruments address I. Phillips, 14 Marietta St., Atlanta, Ga., mentioning this journal.

THE firm of A. A. Marks, 701 Broadway, N. Y., have displayed great enterprise in the manufacture of artificial limbs. See their adv.

WHETHER Considered from a culinary or scientific standpoint, it must be conceded that Highland Brand Evaporated Cream is the ideal form of milk, as it has all the relishing properties of the unprepared article, with the advantage of convenience and absolute safety from all forms of germ life.

"I SEE you are advertising again for a runaway dog. This is the third time in a single month!"

"Yes, bother it! Since my daughter has begun tak. ing music lessons I can't keep a dog in the house.London Tid-Bits.

FOR an absolutely perfect Ladies' Syringe address the Aloe & Penfold Co., Omaha, Neb.

The Song of the Saddle-Bags.
By H. C. S.

Faded and rusty, mud-spattered and worn,
Rifled of contents, bottles broken and gone,
Covered with dust, I hang here and mourn
For the days of yore;

When the world bowed down to me,

As I sang this song exultingly :-

"Now and forever, the whole round world wags, To the rhythmic song of the saddle-bags!"

In palace and cottage, at sea or shore,
'Mid sunshine or storm, I continued to pour
Forth my treasures of healing frail man to restore
To comfort and health.

Requiring no thanks, accepting no fee,
Again and again I sang joyously :-
"Now and forever, the whole round world wags,
To the rhythmic song of the saddle-cags!"

Like Napoleon I sigh'd, "the world is small!"

I longed for new races--to conquer them all.

I laughed when 'twas whispered I might have a fall From my high estate.

:

I grew pompous and proud and vain as could be,
And continued my song exultingly :-
Now and forever, the whole round world wags,
To the rhythmic song of the saddle bags!"

Oh, 'tis better, indeed, that my hopeless disgrace
Shou'd be caused by a changeable human race

In its boasted progression (for such they've the face
To proclaim it!)

:

Old, battered, helpless, I accept the decree,
E'en though I murmur impatiently :-
"Never again! the whole round world wags,
To a later song than the saddle-bags!"

There's a lesson of sorrow for you in my song;
A lesson for all who believe themselves strong.
Remember that pride and great strength belong
To youth, and like me

The subject of jeers you may live to be,
As you childishly moan in your misery:-
"Never again! the whole round world wags,
To a later song than the saddle-bags!"

Indiana Medical Journal.

SEE the admirable reasoning in favor of the hypophosphites on the title page of this issue.

WE always hear good reports from our readers of the woven goods of Flavell & Bro., 1005 Spring Garden St., Phila.

HAVE you yet used uterine wafers in the treatment of female diseases. Send to the Walker Pharmacal Co., St. Louis, Mo., for samples, and mention this journal.

HE DID NOT MIND -Teacher-Johnny, why is George Brown absent ?

Jhnny-Why, George Brown says his sister's got a cold. But that ain't nothin'; one o' my sisters is got de smallpox, and t'other one de measles, but I come all de

same.

FOR Concentrated medication, address, B. Keith & Co., Organic Chemists, 75 William St., New York.

WRITE to the Health Restorative Co., 90 South 5th Ave., N. Y., for their Febricide Pills. Mention this journal.

As an anodyne use Battle & Co.'s Papine, the pain relieving principle of opium.

FRIEND "I saw some of your jokes in a book." Humorist (attered)-"Ah, what book was that?" Friend I forgot the name. It was a book published a hundred years ago. I saw it in a second hand book store.- Yankee Blade. As a pleasant laxative Tarrant's Seltzer Aperient is excellent.

FOR gonorrhea use Rigaud & Chapoteau's SantalMidy. Write for sample to E. Fougera & Co., New York.

SEE the three dollar pocket case advertised by Mulford & Co., Philadelphia.

HAVE you yet used Antilupia? If not, write to the Norwich Pharmacal Co., 140 William St., N. Y.

FOR a perfect lithia water-the Hudor Lithiaaddress the Hudor Co., 68 Terrace, Buffalo, N. Y.

To introduce medicines into the various cavities and passages of the human system, place the medicine in a Hall & Ruckel hollow suppository and introduce.

FOR female diseases send for sample uterine wasers to Micajah & Co., Warren, Pa.

He added together the figures that he had placed on the slate. "That makes 496," he said.

"Is that the amount of the bill ?" I a ked.

"Bill?" he replied. "That is the number of the prescription. I want you to know that medicine with me is no longer an experiment, for I have reduced it to a mathematical certainty. Every symptom has its number, and the sum of these numbers indicates the medicine that is needed. I have worked for fifteen years in formulating my prescriptions and perfecting the treatment, but I have it now. Your bill is $10."

I understood that number, and left the office feeling relieved and deeply impressed by the doctor's learning -Harper's Bazaar.

FOR improved batteries, uterine supporters, &c. address the McIntosh Battery and Optical Co., 141 to 143 Wabash Ave., Chicago.

If you want to give iron, try some one of the formulas used by the Upjohn Pill & Granule Co., Kalamazoo, Mich.

THE GERMAN PROFESSOR ON HYPNOTISM.—“Hybnodism," the German professor said thoughtfully, "vos a mendal disorder dot vos raging brincipally in der noosebapers. It vos a hypertrophy auf der imach ination, undt der writers on mendal pheenomenons vos first attacked. Yon mighd call it a sort ouf writer's cramp auf der prain. Der ingrediences peen made auf a fool undt a rascal. Mix thoroughly undt set avay in a cool blace. Bud one well authendicated case has peen reported, undt dot vos told py a notorious liar auf France. As a defence for der lawyers to sed up in murder drials it vould peen a pudding, as Schiller saidt; but its brincipal use so far alreaty has peen confined to sheap novels undt skyentific makazines. Fife touand years ago a Greek philosopher hybnodized a rooster shicken mit a straight chalk mark on der floor, undt now, in 1892, der skyentifie beeples discofer dot

The

We expect to publish a special number on the subject of Pneumonia some time during the coming winter, probably in January.

Thoughts on Various Phases of Malaria. THERE is a strong conservative tendency in human nature to "Let well enough alone." We think that we see a marked manifestation of this in the indisposition of the profession to consider anything but the bark of the cinchcna tree in the therapeutics of the various manifestations of malaria. We feel sure that by this narrowing of ideas much efficiency in the treatment of the diseased conditions engendered

by malaria is lost. The administration of quinine is a genuine art, and it should be done in each case with a delicacy of discernmert and a fine sense of discrimination as to the time, form, and mode of administration, the dose and the length of intervals, and the assistance to be obtained from other medications, in regard to each individual patient and each diseased condition treated. Thus we will do the greatest amount of good and the least possible harm.

We have found the following drugs valuable substitutes for or aids to quinine in the treatment of acute malarial manifestations : Nitrate of potassium.

Hyposulphite of sodium, sulphite of sodium or sulphite of magnesium, enough to keep the bowels only slightly loose-from ten to thirty grains every two hours.

Picrate of ammonium, from one-fourth to one grain four times a day.

Chinoidin, with the addition of some good stomachic, as capsicum or ginger, to prevent the nausea occasioned by it.

The various preparations of encalyptus globulus.

The administration of antiperiodics should be preceded by a clearing out of the catarrhal secretions of the alimentary tract, so that the proper absorption can take place. For this purpose each practitioner has his favorite laxative.

The use of domestic decoctions for the purpose of breaking up the chill, taken hot when the first symptoms are felt, as a decoction of sun flower-seed, red pepper. strong coffee with lemon juice, and many others, aided by the hot foot-bath, we believe to be most excellent practice, as tending to avert or greatly mitigate the paroxysm and to facilitate the cure of the disease by the antiperiodics administered later, at the proper time. For the same purpose, also, we like the free but careful administration

of chloroform (internally) or a hypodermic of morphine and atropine.

Much can be done for the patient during the stage of fever by the administration of suitable antipyretics and the judicious use of water to reduce the pyrexia and mitigate uncomfortable symptoms. After the sweating stage has passed, a weak ammonia (or other alkaline) bath is especially beneficial. But these remarks must seem mere platitudes, as even the laity understand pretty well how to treat an ordinary intermittent fever.

The form known as remittent fever, or billious fever, we believe to be more than a simple malarial disease. We have encountered it entirely outside of malarial districts as well as within them. The ordinary antiperiodic or anti-malarial treatment seems to have but little effect upon it. Under that treatment it invariably "runs its course." In addition to malaria we have an acute localized inflammation, as of spleen, liver, or some portion of the intestinal tract, &c. Most cases present the symptoms of acute duodenal catarrh, the inflammation frequently involving also the stomach, more or less of the intestines below the duodenum and also the bile ducts. It yields more readily to mild, unirritating laxatives and intestinal antiseptics, but not to quinine. One-tenth grain doses of calomel, the sulphite salts as mentioned before, sulpho-carbolate of zinc, salicylate of

ammonium, sub-ai:rate of bismuth, odoform or the biniodide of mercury, carbolic acid with tincture of iodine, and the usual antipyretics, as aconite, acetanilid, &c., are some of the remedies which will be found most useful in this disease. Singularly enough, we have found phosphorus, in pills of one-one-hundredth of a grain each every two hours, to have a marked effect in cutting short this disease. We wish to have further observation with this treatment, however.

During convalescence, the usual tonics, restraining the appetite and keeping the tongue clean, will be found all that is desired.

*

There seems to be a general state of confusion regarding the disease spoken of as "typho

malarial fever" or "malarial typhoid." We think that a brief inquiry into its pathology should make it plain and simple.

At one time physicians were confronted with a disease which was not typhus fever, but which presented so many of its characteristics that, not knowing its true pathology, they called it "typhoid," meaning "like typhus." We now know this disease to be an inflamm:tion and ulceration of the portion of the small intestine near the ileo-cecal junction, where are located the groups of glands known as Peyer's patches. The most striking phenomenon of this disease is a great prostration of the vital powers, accompanied by a low, muttering delirium, coincident with the discharge, from the surface of the ulcers, of the products of ulceration, and caused by their subsequent absorption from the lower portions of the intestinal tract and the poisoning of the system thereby a veritable blood poisoning. This phase of the disease is particularly referred to as "the typhoid state." This state may occur in many other diseases in which there is long continued acute inflammation and subsequent absorption in large quantities of the inflammatory products. We have it ocasionally in pneumonia, in cystitis, in acute millary tuberculosis, and other diseases in which we have an absorption of inflammatory products. It is not correct to say, in such cases, "typhoid pneumonia," but the "typhoid state in pneumonia," but the pneumonia," and so on through the list. We do not deny the possibility that enteric fever and any other disease may happen to occur at the same time. But we regard it as an exceedingly rare accident.

Now, in the so called typho malarial fever there is no ulceration of Peyer's patches, hence no typhoid fever (or enteric fever, as it is properly called); but there is long continued high fever, hence a corresponding acute inflammation of some tissue or organ of the system. If that proceed so far that there is sufficient absorption of inflammatory products to overwhelm the vital powers, we have the typhoid condition just as we would have in true enteric fever, and from a similar cause. Here those agents that successfully combat blood poisoning are indicated the salicylates, alcohol, the

more active mercury salts, permanganate of potassium, turpentine, &c.

*

"Chronic Malaria" is in most cases also a misnomer. Let us examine a person who has had repeated attacks of intermittent fever. He is in a debilitated condition. His appetite is capricious. He has every day or every second day an imperfectly defined stage of vital depression followed by slight fever, which passes off, leaving him weak but apparently well.

Now this patient had originally intermittent fever, caused by the malarial germ in the blood, but he hasn't it now. It was cured, very likely, by the use of quinine. But quinine does but little good in his present state. Why? The subsidence of the original attack has left him with sub-acute gastric or duodenal catarrh or sub-acute inflammation of the spleen or other organ. This is the chronic lesion, only a relic of the original malarial attack, which leaves him in a non resistant state, especially liable to be again affected by acute malaria or other acute disease, and having in a mild form, a true hectic--a daily or tertian struggle to eliminate from the system the absorbed products of the chronic inflammation. In this condition arsenic and systemic tonics act with especial benefit. The chronic gastric catarrh, almost always present, must be treated as a special cor di ion. Alkaline draughts and hydrastis are of the greatest value. Arsenic, coca and the bitter tonics-especially quassia and dogwood-are also of great value.

inal laxatives and antiseptics are indispensible in the treatment. Capsicum and salicylate of

ammonium are of service.

*

So, then, when having charge of a person afflicted with acute malaria our duty is twofold to prevent the development of chronic lesions by antipyretics and suitable local treatment of the vital organ especially affected, and to counteract the poison in the system by suitable specific treatment.

WE will send THE MEDICAL WORLD free for the remainder of this year to those who send their subscription now for the year 1893. Thus you get the journal one and one third years for the price of only one year. We do this for the sake of getting you to once become a member of our circle, when we believe you will be unwilling to ever leave it.

Original Communications.

Short articles on the treatment of diseases, and experience with new remedies, are solicited from the profession for this department; also difficult cases for diagnosis and treatment.

Articles accepted must be contributed to this journal only The editors are not responsible for views expressed by contributors.

Copy must be received on or before the twelfth of the month for publication in the next month. Unused Manuscript cannot be returned.

Certainly it is excellent discipline for an author to feel that he must say all he has to say in the fewest possible words, or his reader is sure to skip them; and in the plainest possible words, or his reader will certainly misunderstand them. Generally, also, a downright fact may be told in a plain way; and we want downright facts at present more than anything else.-RUSKIN.

EDITOR MEDICAL WORLD : The term "malaria " (bad air) is as good as any other. No one knows what it is, whence it comes, or whither it goes.

One

books that it cannot exist without long conIt is taught in some of the schools and text tinued heat, moisture, and decaying vegetable matter. This may or may not be true. of my old masters, whose voice is now for ever silent, taught that malaria is in every place except two. These were (a) Hades, where it is two hot, and (b) Heaven, where there is no evil thing. Under certain circumstances a kind of bad air may be produced where the above named conditions do not exist. But the worst manifestations of malaria are never seen except after long continued hot weather, with moisture and decaying vegetable matter. Malaria loves the ground and seldom leaves it very far, but, like fog, it may sometimes go higher than at other times. Sleeping in the second or thiri story of a house may prevent its injurious effects one time, and do no good another time, because the malaria may go higher. Malaria may, like fog, include only one room or part of a room of a house in its territory. It may strike down with deadly disease every inmate of one room, while others in the same house are not injured. Look at fog on a cold, frosty morning; see how the wind shifts it about; see it climb up high in one place, and remain near the ground in another; see the sun rise and dispel it, to return again after sunset. Watch it closely,