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absorption acetylators acid active ADRs adult albumin alcohol Alkaline diuresis allergy anticonvulsants antidepressants benzodiazepines blood flow body carbamazepine cause clinical pharmacology compliance CrCl Creatinine clearance curve decreased digoxin Distribution Vd diuresis dosage dose adjustment dose interval drug clearance drug concentration drug effects drug elimination drug interactions drug metabolism Drug-Induced e.g. penicillin elderly enzyme induction equation Ethanol excreted unchanged first-pass metabolism foetal Food fraction free drug glomerular filtration glucuronidation Haemodialysis half-life hepatic increased infant ingestion inhibitors ionised kidneys lipid lipid-soluble lithium liver disease loading dose low therapeutic index maintenance dose measured mediated medication metabolised mg/L milk neonate non-compliance NSAIDs occur oral availability Paracetamol patient penicillin Pharmacodynamic Pharmacokinetics Phenobarbitone phenytoin plasma plasma concentration Cp poisonings polymorphism pregnancy protein protein binding rate of elimination receptor renal impairment syndrome systemic circulation target Theophylline therapeutic drug monitoring therapeutic index total drug toxicity trough concentration umol/L unionised usually volume of distribution