Response Variability to Psychotropic DrugsW. Janke |
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Page 33
... somatic ( neurochemical and neurophysiological ) and behavioral state . The two most important classes of predictor variables which are to be regarded as indirect drug modifiers are long - lasting individual characteristics ( somatic ...
... somatic ( neurochemical and neurophysiological ) and behavioral state . The two most important classes of predictor variables which are to be regarded as indirect drug modifiers are long - lasting individual characteristics ( somatic ...
Page 39
... somatic and behavioral level , which have been investigated in several experi- ments . For a review of behavioral factors see Janke and others ( 1979 ) ; for a review of somatic factors see Netter ( this volume ) . As Table 2 shows it ...
... somatic and behavioral level , which have been investigated in several experi- ments . For a review of behavioral factors see Janke and others ( 1979 ) ; for a review of somatic factors see Netter ( this volume ) . As Table 2 shows it ...
Page 68
... somatic factors of subjects on interindividual differences in drug response . In clinical studies the nature and severity of disease , of course , was acknowledged to be one of the most important somatic factors responsible for ...
... somatic factors of subjects on interindividual differences in drug response . In clinical studies the nature and severity of disease , of course , was acknowledged to be one of the most important somatic factors responsible for ...
Contents
Drug Response Variability Overview of Contributing Factors | 31 |
Somatic factors as predictors of psychotropic drug response | 67 |
Genetic and early environmental factors in response variability | 97 |
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activity administration adrenergic drugs alcohol amitriptyline analysis antidepressant anxiety arousal behavioral biochemical blood levels changes chlordiazepoxide chlorpromazine Claridge Clin clinical concentration correlation Debus depressant drugs depressed patients diazepam DiMascio dose drug effects drug metabolism drug postulate drug response variability drug tolerance emotional responses environmental and situational enzyme evidence experiment experimental extraverts females genetic factors H. J. Eysenck hexobarbitone imipramine increase individual differences influence interaction introverts investigated iproniazid Janke kinetic Lienert lofepramine male measures ment meprobamate neurotic neuroticism nicotine nortriptyline orciprenaline performance personality traits pharmacokinetic Pharmacol pharmacological physiological placebo plasma levels prediction predictors pretreatment Psychiatry psychoactive drugs Psychol psychological psychopharmacology psychotropic drugs questionnaire reactions relationship reported response variability sample sedation threshold significant situational conditions smoking behaviour somatic specific stimulant studies subjects scoring symptoms Table theory therapeutic tion tranquilizers treatment variability to psychotropic variance Wesnes Wittenborn