Response Variability to Psychotropic DrugsW. Janke |
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Page 13
... enzyme catalysing this pathway performs a bifunctional catalysis it is termed mixed function oxidase . The enzyme has been characterized as a hemo- protein occurring in greatest amounts in the parenchymal cells of the liver . As a ...
... enzyme catalysing this pathway performs a bifunctional catalysis it is termed mixed function oxidase . The enzyme has been characterized as a hemo- protein occurring in greatest amounts in the parenchymal cells of the liver . As a ...
Page 22
... enzymes . This may result in two genetically distinct subtypes of the same enzyme showing quantitative differences in activity . Whereas polyge- nic control is expressed in unimodal distributions of enzyme activities in a population ...
... enzymes . This may result in two genetically distinct subtypes of the same enzyme showing quantitative differences in activity . Whereas polyge- nic control is expressed in unimodal distributions of enzyme activities in a population ...
Page 23
... enzyme synthesis by enzyme inducers is of greater clinical relevance than enzyme inhibition . The best known and most potent stimulators are phenobarbitone and other barbiturates , which have been shown to increase , among others , the ...
... enzyme synthesis by enzyme inducers is of greater clinical relevance than enzyme inhibition . The best known and most potent stimulators are phenobarbitone and other barbiturates , which have been shown to increase , among others , the ...
Contents
Drug Response Variability Overview of Contributing Factors | 31 |
Somatic factors as predictors of psychotropic drug response | 67 |
Genetic and early environmental factors in response variability | 97 |
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activity administration adrenergic drugs alcohol amitriptyline analysis antidepressant anxiety arousal behavioral biochemical blood levels changes chlordiazepoxide chlorpromazine Claridge Clin clinical concentration correlation Debus depressant drugs depressed patients diazepam DiMascio dose drug effects drug metabolism drug postulate drug response variability drug tolerance emotional responses environmental and situational enzyme evidence experiment experimental extraverts females genetic factors H. J. Eysenck hexobarbitone imipramine increase individual differences influence interaction introverts investigated iproniazid Janke kinetic Lienert lofepramine male measures ment meprobamate neurotic neuroticism nicotine nortriptyline orciprenaline performance personality traits pharmacokinetic Pharmacol pharmacological physiological placebo plasma levels prediction predictors pretreatment Psychiatry psychoactive drugs Psychol psychological psychopharmacology psychotropic drugs questionnaire reactions relationship reported response variability sample sedation threshold significant situational conditions smoking behaviour somatic specific stimulant studies subjects scoring symptoms Table theory therapeutic tion tranquilizers treatment variability to psychotropic variance Wesnes Wittenborn