Response variability to psychotropic drugs

activity administration adrenergic drugs alcohol amitriptyline analysis antidepressant anxiety arousal behavior chlordiazepoxide chlorpromazine cigarettes smoked Claridge Clin clinical correlation Debus depressant drugs depressed patients diazepam differential DiMascio dose drug effects drug metabolism drug postulate drug response drug tolerance emotional responses environmental enzyme evidence experiment experimental extraverts females H. J. Eysenck hexobarbitone human imipramine increase individual differences influence interaction introverts investigation iproniazid Janke Lehmann and Hopes Lienert lofepramine male measures ment meprobamate MHPG neurotic neuroticism nicotine nortriptyline orciprenaline performance personality pharmacokinetic Pharmacol pharmacological physiological placebo placebo group posttreatment prediction predictors pretreatment Psychiatry psychoactive drugs Psychol psychological psychopharmacology psychoticism psychotropic drugs questionnaire reactions relationship reported response variability sample sedation threshold self-medication significant situational conditions smoking behaviour somatic specific stimulant studies subjects scoring symptoms Table therapeutic tion traits tranquilizer transmarginal inhibition treatment Warburton Wesnes Wittenborn